Arrestin-C - calcitonin receptor-like receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
calcitonin -like 73.8
Arrestin-C 79.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 19.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 K 249 - s8s9 P 130 N.s8s9.04
Van-der-waals ICL2 K 249 - s8s9 P 130 N.s8s9.04
Hydrophobic ICL3 T 323 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL3 T 323 - s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 L 316 5x61 S6 F 71 N.S6.01
Hydrophobic ICL3 T 323 - S6 K 73 N.S6.03
Polar ICL3 V 322 - S6 K 73 N.S6.03
Hydrophobic ICL3 V 322 - S6 K 73 N.S6.03
Van-der-waals ICL3 V 322 - S6 K 73 N.S6.03
Hydrophobic TM5 L 316 5x61 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 L 316 5x61 s5s6 L 69 N.s5s6.10
Polar TM5 K 319 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 K 319 5x64 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 K 319 5x64 s15s16 Y 241 C.s15s16.03
Polar TM3 Y 236 3x53 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 V 245 - S15 V 238 C.S15.14
Polar ICL2 E 248 - s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 E 248 - s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 E 248 - s8s9 D 132 N.s8s9.06
Hydrophobic ICL3 V 322 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 F 246 - s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 F 246 - s8s9 D 132 N.s8s9.06
Polar ICL2 V 245 - S5 Y 59 N.S5.12
Hydrophobic ICL2 V 245 - S5 Y 59 N.S5.12
Van-der-waals ICL2 V 245 - S5 Y 59 N.S5.12
Hydrophobic ICL2 A 247 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 A 247 - s5s6 R 61 N.s5s6.02
Polar ICL2 V 245 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 V 245 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 V 245 - s5s6 R 61 N.s5s6.02
Hydrophobic TM3 L 237 3x54 s5s6 I 67 N.s5s6.08
Polar ICL2 A 247 - s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 A 247 - s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 A 247 - s8s9 D 132 N.s8s9.06
Hydrophobic TM3 I 241 3x58 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 I 241 3x58 s5s6 L 64 N.s5s6.05
Polar ICL2 A 244 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 A 244 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 A 244 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 F 246 - S9 C 137 N.S9.01
Van-der-waals ICL2 F 246 - S9 C 137 N.S9.01
Hydrophobic ICL2 F 246 - s8s9 Q 127 N.s8s9.01
Polar ICL2 F 246 - S16 Y 246 C.S16.03
Aromatic ICL2 F 246 - S16 Y 246 C.S16.03
Hydrophobic ICL2 F 246 - S16 Y 246 C.S16.03
Van-der-waals ICL2 F 246 - S16 Y 246 C.S16.03
Hydrophobic ICL3 T 323 - S6 R 72 N.S6.02
Van-der-waals ICL3 T 323 - S6 R 72 N.S6.02
Hydrophobic TM6 K 333 6x37 s5s6 L 69 N.s5s6.10
Polar TM2 R 173 2x46 s5s6 D 62 N.s5s6.03
Van-der-waals TM2 R 173 2x46 s5s6 D 62 N.s5s6.03
Hydrophobic TM5 L 320 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 L 240 3x57 s5s6 D 63 N.s5s6.04
Van-der-waals TM3 L 240 3x57 s5s6 D 63 N.s5s6.04
Polar TM3 L 240 3x57 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 L 240 3x57 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 L 240 3x57 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 V 245 - s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 V 245 - s15s16 S 242 C.s15s16.04
Hydrophobic TM2 C 171 2x44 s8s9 A 133 N.s8s9.07
Hydrophobic ICL3 V 322 - s15s16 L 240 C.s15s16.02
Ionic TM2 R 173 2x46 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 R 173 2x46 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 R 173 2x46 s5s6 D 63 N.s5s6.04
Polar ICL2 A 244 - S5 Y 59 N.S5.12
Van-der-waals ICL2 A 244 - S5 Y 59 N.S5.12
Hydrophobic TM6 A 337 6x41 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 A 337 6x41 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 F 246 - s8s9 P 128 N.s8s9.02
Van-der-waals ICL2 F 246 - s8s9 P 128 N.s8s9.02
Hydrophobic TM3 I 241 3x58 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 I 241 3x58 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 V 245 - S9 C 137 N.S9.01
Van-der-waals ICL2 V 245 - S9 C 137 N.S9.01
Hydrophobic TM7 F 384 7x57 s5s6 V 66 N.s5s6.07
Polar ICL2 K 249 - s8s9 E 131 N.s8s9.05
Hydrophobic ICL2 K 249 - s8s9 E 131 N.s8s9.05
Van-der-waals ICL2 K 249 - s8s9 E 131 N.s8s9.05
Hydrophobic TM3 V 243 3x60 S16 D 244 C.S16.01
Van-der-waals TM3 V 243 3x60 S16 D 244 C.S16.01
Polar ICL2 V 245 - S16 Y 246 C.S16.03
Hydrophobic ICL2 V 245 - S16 Y 246 C.S16.03
Van-der-waals ICL2 V 245 - S16 Y 246 C.S16.03
Polar ICL2 V 245 - S16 D 244 C.S16.01
Hydrophobic ICL2 V 245 - S16 D 244 C.S16.01
Van-der-waals ICL2 V 245 - S16 D 244 C.S16.01
Hydrophobic TM2 R 173 2x46 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 R 173 2x46 s5s6 V 66 N.s5s6.07
Polar ICL2 A 244 - S16 D 244 C.S16.01
Hydrophobic ICL2 A 244 - S16 D 244 C.S16.01
Van-der-waals ICL2 A 244 - S16 D 244 C.S16.01
Polar ICL2 F 246 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 F 246 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 F 246 - s5s6 R 61 N.s5s6.02
Aromatic TM5 K 319 5x64 S6 F 71 N.S6.01
Hydrophobic TM5 K 319 5x64 S6 F 71 N.S6.01
Van-der-waals TM5 K 319 5x64 S6 F 71 N.S6.01
Ionic H8 R 397 8x56 s20c E 383 C.s20c.17
Polar H8 R 397 8x56 s20c E 383 C.s20c.17
Hydrophobic H8 R 397 8x56 s20c E 383 C.s20c.17
Van-der-waals H8 R 397 8x56 s20c E 383 C.s20c.17
Hydrophobic ICL2 F 246 - S8 L 126 N.S8.03
Van-der-waals ICL2 F 246 - S8 L 126 N.S8.03