Beta-arrestin-2 - CCK1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
CCK1 79.2
Beta-arrestin-2 80.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL3 S 300 - S6 D 79 N.S6.04
Van-der-waals ICL3 S 300 - S6 D 79 N.S6.04
Polar ICL2 Q 153 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Q 153 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Q 153 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 147 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 147 34x51 S16 A 248 C.S16.01
Hydrophobic TM2 N 77 2x40 s5s6 V 71 N.s5s6.07
Polar ICL2 Q 148 34x52 s15s16 S 246 C.s15s16.04
Ionic H8 R 376 8x49 s5s6 D 70 N.s5s6.06
Polar H8 R 376 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic H8 R 376 8x49 s5s6 D 70 N.s5s6.06
Van-der-waals H8 R 376 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 V 151 34x55 S16 Y 250 C.S16.03
Polar TM4 K 155 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 K 155 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 K 155 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM6 M 314 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 M 314 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 Q 148 34x52 S16 A 248 C.S16.01
Van-der-waals ICL2 Q 148 34x52 S16 A 248 C.S16.01
Hydrophobic TM2 L 80 2x43 s5s6 V 71 N.s5s6.07
Polar ICL2 R 150 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 R 150 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 150 34x54 s5s6 R 66 N.s5s6.02
Polar C-term E 404 - s20c Q 407 C.s20c.17
Hydrophobic TM2 T 76 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM6 V 311 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 311 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 L 236 5x65 s5s6 L 74 N.s5s6.10
Polar ICL2 R 150 34x54 s8s9 K 139 N.s8s9.09
Polar C-term G 406 - s20c Y 404 C.s20c.14
Hydrophobic C-term G 406 - s20c Y 404 C.s20c.14
Van-der-waals C-term G 406 - s20c Y 404 C.s20c.14
Polar C-term E 405 - s20c Y 404 C.s20c.14
Hydrophobic C-term E 405 - s20c Y 404 C.s20c.14
Van-der-waals C-term E 405 - s20c Y 404 C.s20c.14
Hydrophobic TM3 I 143 3x54 s5s6 L 74 N.s5s6.10
Polar ICL2 Q 148 34x52 s15s16 T 247 C.s15s16.05
Polar TM6 N 304 6x26 s5s6 S 75 N.s5s6.11
Polar ICL2 S 149 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 S 149 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 S 149 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 147 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 L 147 34x51 s15s16 S 246 C.s15s16.04
Ionic C-term E 404 - s9s10 K 161 N.s9s10.12
Polar C-term E 404 - s9s10 K 161 N.s9s10.12
Van-der-waals C-term E 404 - s9s10 K 161 N.s9s10.12
Polar H8 N 374 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic H8 N 374 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 N 374 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 L 147 34x51 S9 C 141 N.S9.01
Hydrophobic TM3 I 143 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 143 3x54 s5s6 L 72 N.s5s6.08
Polar C-term G 407 - s20c Y 404 C.s20c.14
Van-der-waals C-term G 407 - s20c Y 404 C.s20c.14
Hydrophobic ICL2 P 146 34x50 S5 Y 64 N.S5.12
Polar C-term E 399 - s9s10 K 161 N.s9s10.12
Hydrophobic C-term E 399 - s9s10 K 161 N.s9s10.12
Van-der-waals C-term E 399 - s9s10 K 161 N.s9s10.12
Polar C-term E 399 - s9s10 R 162 N.s9s10.13
Hydrophobic C-term E 399 - s9s10 R 162 N.s9s10.13
Van-der-waals C-term E 399 - s9s10 R 162 N.s9s10.13
Hydrophobic TM4 T 154 4x38 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 T 154 4x38 s8s9 E 135 N.s8s9.05
Ionic H8 R 376 8x49 s5s6 E 67 N.s5s6.03
Polar H8 R 376 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic H8 R 376 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 R 376 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic ICL3 S 298 - S6 I 82 N.S6.07
Polar ICL2 R 150 34x54 s5s6 G 65 N.s5s6.01
Hydrophobic ICL2 R 150 34x54 s5s6 G 65 N.s5s6.01
Van-der-waals ICL2 R 150 34x54 s5s6 G 65 N.s5s6.01
Polar TM4 S 156 4x40 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 S 156 4x40 s8s9 E 135 N.s8s9.05
Ionic ICL3 R 297 - s9s10 E 156 N.s9s10.07
Polar ICL3 R 297 - s9s10 E 156 N.s9s10.07
Van-der-waals ICL3 R 297 - s9s10 E 156 N.s9s10.07
Hydrophobic ICL2 L 147 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 147 34x51 S15 I 242 C.S15.14
Polar C-term E 404 - s20c Y 404 C.s20c.14
Hydrophobic C-term E 404 - s20c Y 404 C.s20c.14
Van-der-waals C-term E 404 - s20c Y 404 C.s20c.14
Hydrophobic TM6 A 307 6x29 s5s6 L 74 N.s5s6.10
Polar ICL2 R 150 34x54 S5 Y 64 N.S5.12
Polar ICL2 L 147 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 147 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 147 34x51 S16 Y 250 C.S16.03
Hydrophobic TM3 I 143 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 143 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM4 T 154 4x38 s17s18 R 286 C.s17s18.11
Van-der-waals TM4 T 154 4x38 s17s18 R 286 C.s17s18.11
Hydrophobic TM3 R 139 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 139 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 R 150 34x54 S9 C 141 N.S9.01
Van-der-waals ICL2 R 150 34x54 S9 C 141 N.S9.01
Hydrophobic TM3 A 142 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 142 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM2 T 74 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 I 143 3x54 S6 F 76 N.S6.01
Hydrophobic TM6 V 311 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 K 308 6x30 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 T 76 2x39 s5s6 V 71 N.s5s6.07