S-arrestin - CCK1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
CCK1 78.1
S-arrestin 82.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 A 307 6x29 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 A 303 6x25 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 A 303 6x25 s9s10 D 166 N.s9s10.08
Polar ICL3 N 299 - s9s10 A 163 N.s9s10.05
Hydrophobic ICL3 N 299 - s9s10 A 163 N.s9s10.05
Van-der-waals ICL3 N 299 - s9s10 A 163 N.s9s10.05
Polar ICL2 R 150 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 R 150 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 150 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic TM2 T 76 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 T 76 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 A 142 3x53 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 A 142 3x53 s5s6 I 76 N.s5s6.05
Polar TM4 K 155 4x39 s8s9 D 142 N.s8s9.06
Polar H8 N 374 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic H8 N 374 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 N 374 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 M 314 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 I 143 3x54 s5s6 I 79 N.s5s6.08
Polar ICL2 R 150 34x54 s5s6 G 72 N.s5s6.01
Polar ICL2 Q 148 34x52 S16 Y 259 C.S16.03
Van-der-waals ICL2 Q 148 34x52 S16 Y 259 C.S16.03
Polar ICL2 Q 148 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 Q 148 34x52 S16 D 257 C.S16.01
Hydrophobic C-term E 403 - S10 L 177 N.S10.05
Van-der-waals C-term E 403 - S10 L 177 N.S10.05
Hydrophobic TM3 A 142 3x53 S6 F 83 N.S6.01
Ionic C-term E 405 - s17s18 H 305 C.s17s18.21
Polar C-term E 405 - s17s18 H 305 C.s17s18.21
Hydrophobic C-term E 405 - s17s18 H 305 C.s17s18.21
Van-der-waals C-term E 405 - s17s18 H 305 C.s17s18.21
Polar ICL2 L 147 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 L 147 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 L 147 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 L 147 34x51 S16 D 257 C.S16.01
Hydrophobic ICL2 L 147 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 L 147 34x51 S15 V 251 C.S15.14
Polar ICL3 N 299 - s9s10 E 165 N.s9s10.07
Hydrophobic ICL3 N 299 - s9s10 E 165 N.s9s10.07
Van-der-waals ICL3 N 299 - s9s10 E 165 N.s9s10.07
Hydrophobic ICL3 R 297 - S6 F 89 N.S6.07
Van-der-waals ICL3 R 297 - S6 F 89 N.S6.07
Hydrophobic TM3 I 143 3x54 s5s6 L 81 N.s5s6.10
Ionic C-term E 405 - s17s18 K 304 C.s17s18.20
Polar C-term E 405 - s17s18 K 304 C.s17s18.20
Hydrophobic C-term E 405 - s17s18 K 304 C.s17s18.20
Van-der-waals C-term E 405 - s17s18 K 304 C.s17s18.20
Ionic H8 R 376 8x49 s5s6 E 74 N.s5s6.03
Polar H8 R 376 8x49 s5s6 E 74 N.s5s6.03
Van-der-waals H8 R 376 8x49 s5s6 E 74 N.s5s6.03
Hydrophobic TM5 F 242 5x71 S6 R 85 N.S6.03
Van-der-waals TM5 F 242 5x71 S6 R 85 N.S6.03
Hydrophobic ICL2 R 150 34x54 S9 C 147 N.S9.01
Van-der-waals ICL2 R 150 34x54 S9 C 147 N.S9.01
Hydrophobic ICL2 L 147 34x51 S9 C 147 N.S9.01
Van-der-waals ICL2 L 147 34x51 S9 C 147 N.S9.01
Hydrophobic ICL3 N 299 - S6 F 89 N.S6.07
Polar ICL2 R 150 34x54 S5 Y 71 N.S5.12
Hydrophobic ICL2 R 150 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 R 150 34x54 S5 Y 71 N.S5.12
Hydrophobic TM5 L 236 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 236 5x65 s5s6 L 81 N.s5s6.10
Ionic C-term E 403 - S5 R 70 N.S5.11
Polar C-term E 403 - S5 R 70 N.S5.11
Van-der-waals C-term E 403 - S5 R 70 N.S5.11
Hydrophobic TM2 T 74 2x37 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 T 74 2x37 s5s6 D 75 N.s5s6.04
Polar ICL2 Q 153 34x57 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 Q 153 34x57 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 Q 153 34x57 s8s9 K 145 N.s8s9.09
Polar ICL3 R 297 - s9s10 T 161 N.s9s10.03
Hydrophobic TM6 V 311 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 V 311 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM7 Y 370 7x53 s5s6 V 78 N.s5s6.07
Hydrophobic TM2 N 77 2x40 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 N 77 2x40 s5s6 V 78 N.s5s6.07
Ionic H8 R 376 8x49 s5s6 D 77 N.s5s6.06
Polar H8 R 376 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 R 376 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 R 376 8x49 s5s6 D 77 N.s5s6.06
Polar C-term E 405 - s20c N 386 C.s20c.05
Van-der-waals C-term E 405 - s20c N 386 C.s20c.05
Polar TM6 S 301 6x23 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 S 301 6x23 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 V 311 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 P 146 34x50 S5 Y 71 N.S5.12
Polar H8 N 374 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 N 374 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 374 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic TM2 L 80 2x43 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 L 80 2x43 s5s6 V 78 N.s5s6.07
Hydrophobic TM4 T 154 4x38 s8s9 D 142 N.s8s9.06
Van-der-waals TM4 T 154 4x38 s8s9 D 142 N.s8s9.06
Hydrophobic ICL3 R 297 - s9s10 A 163 N.s9s10.05
Van-der-waals ICL3 R 297 - s9s10 A 163 N.s9s10.05
Polar ICL2 Q 153 34x57 s5s6 Q 73 N.s5s6.02
Van-der-waals ICL2 Q 153 34x57 s5s6 Q 73 N.s5s6.02
Polar ICL2 R 150 34x54 s8s9 S 146 N.s8s9.10
Hydrophobic ICL2 R 150 34x54 s8s9 S 146 N.s8s9.10
Van-der-waals ICL2 R 150 34x54 s8s9 S 146 N.s8s9.10
Hydrophobic TM6 K 308 6x30 s5s6 L 81 N.s5s6.10
Polar C-term E 402 - s5s6 E 74 N.s5s6.03
Hydrophobic C-term E 402 - s5s6 E 74 N.s5s6.03
Polar TM2 V 75 2x38 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 V 75 2x38 s5s6 D 75 N.s5s6.04
Ionic C-term E 403 - s17s18 K 302 C.s17s18.18
Polar C-term E 403 - s17s18 K 302 C.s17s18.18
Hydrophobic TM3 R 139 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 139 3x50 s5s6 I 79 N.s5s6.08
Ionic C-term E 405 - s17s18 K 302 C.s17s18.18
Polar C-term E 405 - s17s18 K 302 C.s17s18.18
Hydrophobic TM3 I 143 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 143 3x54 S6 F 83 N.S6.01