G12 - CCK1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
CCK1 78.3
subunit alpha-12 84.7
Gβ1 93.4
Gγ2 84.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 146 34x50 G.H5 I 370 G.H5.15
Polar ICL2 R 150 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic C-term A 411 - G.H3 K 284 G.H3.16
Van-der-waals C-term A 411 - G.H3 K 284 G.H3.16
Polar TM6 N 304 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 N 304 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 N 304 6x26 G.H5 Q 372 G.H5.17
Hydrophobic H8 K 375 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 375 8x48 G.H5 Q 381 G.H5.26
Polar C-term E 403 - G.h4s6 S 343 G.h4s6.12
Hydrophobic C-term E 403 - G.h4s6 S 343 G.h4s6.12
Van-der-waals C-term E 403 - G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL2 V 151 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 V 151 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM7 Y 370 7x53 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 147 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM6 V 311 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 311 6x33 G.H5 M 379 G.H5.24
Polar C-term G 410 - G.H3 K 284 G.H3.16
Hydrophobic C-term G 410 - G.H3 K 284 G.H3.16
Van-der-waals C-term G 410 - G.H3 K 284 G.H3.16
Polar TM3 R 139 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 I 378 G.H5.23
Polar ICL3 N 299 - G.S6 L 346 G.S6.01
Hydrophobic ICL2 L 147 34x51 G.S1 V 58 G.S1.02
Hydrophobic ICL2 R 150 34x54 G.H5 I 370 G.H5.15
Hydrophobic ICL3 I 296 - G.S6 H 349 G.S6.04
Hydrophobic TM3 I 143 3x54 G.H5 L 371 G.H5.16
Polar ICL3 N 294 - G.H4 E 325 G.H4.05
Hydrophobic ICL3 N 294 - G.H4 E 325 G.H4.05
Van-der-waals ICL3 N 294 - G.H4 E 325 G.H4.05
Polar TM7 M 373 7x56 G.H5 Q 381 G.H5.26
Van-der-waals TM7 M 373 7x56 G.H5 Q 381 G.H5.26
Hydrophobic TM5 L 236 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 147 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 147 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM7 I 369 7x52 G.H5 L 380 G.H5.25
Van-der-waals TM7 I 369 7x52 G.H5 L 380 G.H5.25
Hydrophobic TM6 M 314 6x36 G.H5 I 378 G.H5.23
Polar H8 R 378 8x51 G.H5 Q 381 G.H5.26
Van-der-waals H8 R 378 8x51 G.H5 Q 381 G.H5.26
Polar C-term T 409 - G.H3 K 284 G.H3.16
Hydrophobic C-term T 409 - G.H3 K 284 G.H3.16
Van-der-waals C-term T 409 - G.H3 K 284 G.H3.16
Hydrophobic H8 N 374 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 N 374 8x47 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 147 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 147 34x51 G.S3 I 221 G.S3.01
Polar ICL3 N 299 - G.H4 D 336 G.H4.16
Hydrophobic ICL2 L 147 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM6 K 308 6x30 G.H5 L 375 G.H5.20
Polar C-term E 403 - G.h4s6 N 341 G.h4s6.10
Hydrophobic ICL2 L 147 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 147 34x51 G.H5 I 370 G.H5.15
Polar C-term Y 418 - G.h4s6 R 340 G.h4s6.09
Hydrophobic TM4 T 154 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 T 154 4x38 G.hns1 R 55 G.hns1.02
Ionic TM5 E 235 5x64 G.H5 K 367 G.H5.12
Polar TM5 E 235 5x64 G.H5 K 367 G.H5.12
Van-der-waals TM5 E 235 5x64 G.H5 K 367 G.H5.12
Hydrophobic ICL3 I 296 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 I 296 - G.H5 F 361 G.H5.06
Ionic H8 R 376 8x49 G.H5 D 377 G.H5.22
Polar H8 R 376 8x49 G.H5 D 377 G.H5.22
Hydrophobic H8 R 376 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 R 376 8x49 G.H5 D 377 G.H5.22
Hydrophobic ICL3 N 299 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL3 S 300 - G.h4s6 P 345 G.h4s6.20
Polar TM3 A 142 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 142 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 142 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM6 V 311 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM6 M 314 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 M 314 6x36 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 146 34x50 G.H5 K 367 G.H5.12
Van-der-waals TM6 R 310 6x32 G.H5 Q 381 G.H5.26
Hydrophobic ICL3 S 298 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 S 298 - G.S6 F 347 G.S6.02
Hydrophobic TM3 I 143 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM6 A 307 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 307 6x29 G.H5 M 379 G.H5.24
Polar C-term E 399 - G.h3s5 N 288 G.h3s5.02
Polar H8 N 374 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 N 374 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 374 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 143 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM7 M 373 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 M 373 7x56 G.H5 L 380 G.H5.25
Hydrophobic C-term L 413 - G.H2 Q 240 G.H2.09
Van-der-waals C-term L 413 - G.H2 Q 240 G.H2.09
Polar ICL3 R 297 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 R 297 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 R 297 - G.S6 H 348 G.S6.03
Ionic TM6 K 308 6x30 G.H5 D 368 G.H5.13
Hydrophobic TM3 A 142 3x53 G.H5 I 378 G.H5.23