Beta-arrestin-2 - CCR10 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
CCR10 74.0
Beta-arrestin-2 77.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 18.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar H8 L 315 8x48 s5s6 D 70 N.s5s6.06
Van-der-waals H8 L 315 8x48 s5s6 D 70 N.s5s6.06
Polar TM2 S 75 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 S 75 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 S 75 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic C-term P 352 - S16 A 248 C.S16.01
Hydrophobic ICL2 P 152 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 P 152 - s5s6 R 66 N.s5s6.02
Hydrophobic C-term C 349 - s17s18 K 285 C.s17s18.10
Van-der-waals C-term C 349 - s17s18 K 285 C.s17s18.10
Hydrophobic C-term C 349 - s17s18 G 287 C.s17s18.12
Hydrophobic TM3 I 142 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 I 142 3x54 S6 F 76 N.S6.01
Hydrophobic TM6 A 245 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 245 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic H8 L 315 8x48 s20c Y 404 C.s20c.14
Hydrophobic TM2 T 77 2x39 s5s6 D 68 N.s5s6.04
Ionic H8 R 316 8x49 s8s9 D 136 N.s8s9.06
Polar H8 R 316 8x49 s8s9 D 136 N.s8s9.06
Hydrophobic H8 R 316 8x49 s8s9 D 136 N.s8s9.06
Van-der-waals H8 R 316 8x49 s8s9 D 136 N.s8s9.06
Hydrophobic TM6 V 249 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 249 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 E 241 6x29 s5s6 G 73 N.s5s6.09
Polar H8 R 316 8x49 s8s9 T 137 N.s8s9.07
Hydrophobic H8 R 316 8x49 s8s9 T 137 N.s8s9.07
Van-der-waals H8 R 316 8x49 s8s9 T 137 N.s8s9.07
Polar TM6 E 241 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 E 241 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 E 241 6x29 s5s6 S 75 N.s5s6.11
Polar C-term C 349 - s17s18 R 286 C.s17s18.11
Hydrophobic C-term C 349 - s17s18 R 286 C.s17s18.11
Van-der-waals C-term C 349 - s17s18 R 286 C.s17s18.11
Van-der-waals C-term S 347 - s17s18 K 285 C.s17s18.10
Hydrophobic H8 Q 319 8x52 s8s9 T 137 N.s8s9.07
Van-der-waals H8 Q 319 8x52 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 L 146 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 L 146 - s15s16 F 245 C.s15s16.03
Polar C-term S 350 - S16 K 251 C.S16.04
Van-der-waals C-term S 350 - S16 K 251 C.S16.04
Polar C-term T 353 - S16 K 251 C.S16.04
Hydrophobic C-term T 353 - S16 K 251 C.S16.04
Van-der-waals C-term T 353 - S16 K 251 C.S16.04
Hydrophobic TM3 R 138 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic C-term L 346 - s17s18 R 286 C.s17s18.11
Van-der-waals C-term L 346 - s17s18 R 286 C.s17s18.11
Hydrophobic C-term T 355 - S16 Q 249 C.S16.02
Van-der-waals C-term T 355 - S16 Q 249 C.S16.02
Ionic TM6 E 241 6x29 s8s9 K 139 N.s8s9.09
Polar TM6 E 241 6x29 s8s9 K 139 N.s8s9.09
Van-der-waals TM6 E 241 6x29 s8s9 K 139 N.s8s9.09
Polar TM6 A 245 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 A 245 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 A 245 6x33 s5s6 L 72 N.s5s6.08
Ionic H8 R 316 8x49 s5s6 E 67 N.s5s6.03
Polar H8 R 316 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic H8 R 316 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 R 316 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 I 142 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 142 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 144 3x56 s15s16 F 245 C.s15s16.03
Van-der-waals TM3 R 144 3x56 s15s16 F 245 C.s15s16.03
Polar ICL1 A 72 12x50 s8s9 E 135 N.s8s9.05
Hydrophobic TM6 V 248 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 A 145 - s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 P 147 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 P 147 - s15s16 F 245 C.s15s16.03
Ionic H8 R 316 8x49 s5s6 D 70 N.s5s6.06
Polar H8 R 316 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic H8 R 316 8x49 s5s6 D 70 N.s5s6.06
Van-der-waals H8 R 316 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic C-term C 349 - S16 K 251 C.S16.04
Van-der-waals C-term C 349 - S16 K 251 C.S16.04
Ionic ICL1 R 71 12x49 s8s9 E 135 N.s8s9.05
Polar ICL1 R 71 12x49 s8s9 E 135 N.s8s9.05
Hydrophobic ICL1 R 71 12x49 s8s9 E 135 N.s8s9.05
Van-der-waals ICL1 R 71 12x49 s8s9 E 135 N.s8s9.05
Hydrophobic H8 G 314 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 G 314 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic H8 G 314 8x47 s5s6 D 70 N.s5s6.06
Van-der-waals H8 G 314 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic C-term C 349 - s17s18 L 288 C.s17s18.13
Hydrophobic TM5 L 234 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 234 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 R 243 6x31 s9s10 K 158 N.s9s10.09
Hydrophobic C-term P 352 - S16 Y 250 C.S16.03
Van-der-waals C-term P 352 - S16 Y 250 C.S16.03
Hydrophobic C-term L 346 - s17s18 E 284 C.s17s18.09
Van-der-waals C-term L 346 - s17s18 E 284 C.s17s18.09
Polar C-term C 349 - S16 C 252 C.S16.05
Hydrophobic C-term C 349 - S16 C 252 C.S16.05
Van-der-waals C-term C 349 - S16 C 252 C.S16.05
Hydrophobic TM7 L 313 7x56 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 A 141 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic C-term P 344 - s17s18 E 284 C.s17s18.09
Polar H8 Q 319 8x52 s20c Y 404 C.s20c.14
Hydrophobic H8 Q 319 8x52 s20c Y 404 C.s20c.14
Van-der-waals H8 Q 319 8x52 s20c Y 404 C.s20c.14
Hydrophobic C-term P 352 - S16 Q 249 C.S16.02
Van-der-waals C-term P 352 - S16 Q 249 C.S16.02
Polar C-term T 353 - S16 Q 249 C.S16.02
Van-der-waals C-term T 353 - S16 Q 249 C.S16.02
Hydrophobic TM3 R 138 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 138 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic C-term L 346 - s8s9 P 134 N.s8s9.04
Van-der-waals C-term L 346 - s8s9 P 134 N.s8s9.04
Hydrophobic ICL2 A 145 - S6 F 76 N.S6.01
Van-der-waals ICL2 A 145 - S6 F 76 N.S6.01
Hydrophobic ICL2 A 145 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 A 145 - s15s16 F 245 C.s15s16.03
Hydrophobic TM3 I 142 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 142 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 P 147 - S6 K 78 N.S6.03
Polar H8 R 316 8x49 s8s9 E 135 N.s8s9.05
Hydrophobic H8 R 316 8x49 s8s9 E 135 N.s8s9.05
Van-der-waals H8 R 316 8x49 s8s9 E 135 N.s8s9.05
Hydrophobic TM3 I 142 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 142 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM7 Y 310 7x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 Y 310 7x53 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 L 230 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 A 141 3x53 s5s6 D 68 N.s5s6.04
Polar H8 R 323 8x56 s8s9 P 134 N.s8s9.04
Van-der-waals H8 R 323 8x56 s8s9 P 134 N.s8s9.04