Arrestin-C - CCR10 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
CCR10 73.7
Arrestin-C 81.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 142 3x54 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 I 142 3x54 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 P 152 - s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 152 - s15s16 S 242 C.s15s16.04
Hydrophobic TM3 R 144 3x56 s15s16 Y 241 C.s15s16.03
Polar TM6 A 245 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 A 245 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 A 245 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals C-term R 343 - S15 K 227 C.S15.03
Ionic H8 R 322 8x55 s20c E 383 C.s20c.17
Polar H8 R 322 8x55 s20c E 383 C.s20c.17
Van-der-waals H8 R 322 8x55 s20c E 383 C.s20c.17
Hydrophobic TM2 R 74 2x36 s8s9 D 132 N.s8s9.06
Van-der-waals TM2 R 74 2x36 s8s9 D 132 N.s8s9.06
Ionic H8 R 316 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic H8 R 316 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 R 316 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic TM5 L 230 5x61 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 R 74 2x36 s8s9 A 133 N.s8s9.07
Hydrophobic TM2 S 75 2x37 s8s9 K 135 N.s8s9.09
Hydrophobic TM6 P 240 6x28 s9s10 K 157 N.s9s10.12
Hydrophobic TM6 V 249 6x37 s5s6 I 67 N.s5s6.08
Polar C-term S 348 - S19 D 339 C.S19.02
Hydrophobic C-term S 348 - S19 D 339 C.S19.02
Van-der-waals C-term S 348 - S19 D 339 C.S19.02
Polar ICL2 A 145 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 A 145 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 A 145 - s15s16 Y 241 C.s15s16.03
Polar TM3 A 141 3x53 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 A 141 3x53 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 A 141 3x53 s5s6 R 61 N.s5s6.02
Ionic TM2 R 74 2x36 s8s9 E 131 N.s8s9.05
Polar TM2 R 74 2x36 s8s9 E 131 N.s8s9.05
Hydrophobic TM2 R 74 2x36 s8s9 E 131 N.s8s9.05
Van-der-waals TM2 R 74 2x36 s8s9 E 131 N.s8s9.05
Hydrophobic TM3 R 138 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 A 141 3x53 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 A 141 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 R 151 - s15s16 L 243 C.s15s16.05
Hydrophobic TM5 L 234 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 L 234 5x65 s5s6 L 69 N.s5s6.10
Ionic H8 R 316 8x49 s5s6 D 62 N.s5s6.03
Polar H8 R 316 8x49 s5s6 D 62 N.s5s6.03
Hydrophobic H8 R 316 8x49 s5s6 D 62 N.s5s6.03
Van-der-waals H8 R 316 8x49 s5s6 D 62 N.s5s6.03
Hydrophobic TM3 I 142 3x54 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 A 145 - S6 F 71 N.S6.01
Van-der-waals ICL2 A 145 - S6 F 71 N.S6.01
Hydrophobic TM7 Y 310 7x53 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 Y 310 7x53 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 I 142 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 I 142 3x54 s5s6 L 69 N.s5s6.10
Polar TM3 R 138 3x50 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 I 142 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 I 142 3x54 S6 F 71 N.S6.01
Hydrophobic ICL2 P 147 - s15s16 Y 241 C.s15s16.03
Polar TM6 E 241 6x29 s5s6 T 70 N.s5s6.11
Hydrophobic TM6 E 241 6x29 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 E 241 6x29 s5s6 T 70 N.s5s6.11
Polar TM2 S 75 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 S 75 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 S 75 2x37 s5s6 D 63 N.s5s6.04
Polar C-term T 353 - S11 R 185 C.S11.05
Hydrophobic C-term T 353 - S11 R 185 C.S11.05
Van-der-waals C-term T 353 - S11 R 185 C.S11.05
Hydrophobic TM6 V 248 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 R 144 3x56 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 R 144 3x56 s5s6 R 61 N.s5s6.02
Hydrophobic H8 G 314 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 G 314 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 L 146 - s15s16 Y 241 C.s15s16.03
Polar H8 L 315 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 P 147 - S6 K 73 N.S6.03
Polar TM2 R 74 2x36 s8s9 P 130 N.s8s9.04
Hydrophobic TM2 R 74 2x36 s8s9 P 130 N.s8s9.04
Van-der-waals TM2 R 74 2x36 s8s9 P 130 N.s8s9.04
Polar TM2 T 77 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 T 77 2x39 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 T 77 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 R 138 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 138 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic H8 G 314 8x47 s5s6 E 65 N.s5s6.06
Hydrophobic TM6 A 245 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 A 245 6x33 s5s6 L 69 N.s5s6.10
Ionic ICL1 R 70 12x48 s8s9 E 131 N.s8s9.05