Beta-arrestin-1 - CCR1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
CCR1 80.2
Beta-arrestin-1 80.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM2 T 69 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 T 69 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 T 69 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 L 142 34x54 S8 L 129 N.S8.03
Van-der-waals ICL2 L 142 34x54 S8 L 129 N.S8.03
Polar ICL2 A 141 34x53 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 A 141 34x53 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 A 141 34x53 s5s6 R 65 N.s5s6.02
Polar TM3 A 134 3x53 S5 Y 63 N.S5.12
Van-der-waals TM3 A 134 3x53 S5 Y 63 N.S5.12
Polar C-term H 349 - s4s5 K 49 N.s4s5.06
Aromatic C-term H 349 - s4s5 K 49 N.s4s5.06
Hydrophobic C-term H 349 - s4s5 K 49 N.s4s5.06
Van-der-waals C-term H 349 - s4s5 K 49 N.s4s5.06
Hydrophobic TM3 R 131 3x50 s5s6 L 68 N.s5s6.05
Hydrophobic ICL3 P 230 - S6 F 75 N.S6.01
Van-der-waals ICL3 P 230 - S6 F 75 N.S6.01
Hydrophobic TM6 N 231 6x27 S6 F 75 N.S6.01
Hydrophobic TM6 A 237 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 237 6x33 s5s6 L 73 N.s5s6.10
Polar H8 F 308 8x50 s5s6 D 69 N.s5s6.06
Polar H8 K 310 8x52 s20c E 407 C.s20c.17
Hydrophobic ICL2 A 138 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 A 138 34x50 s15s16 N 245 C.s15s16.04
Polar TM6 N 231 6x27 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 N 231 6x27 s5s6 T 74 N.s5s6.11
Hydrophobic H8 G 305 8x47 s5s6 V 70 N.s5s6.07
Polar ICL2 R 145 34x57 s17s18 R 285 C.s17s18.11
Hydrophobic TM6 A 237 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 A 237 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 L 142 34x54 s8s9 A 139 N.s8s9.10
Hydrophobic ICL1 K 66 12x51 s8s9 E 134 N.s8s9.05
Van-der-waals ICL1 K 66 12x51 s8s9 E 134 N.s8s9.05
Hydrophobic H8 G 305 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 G 305 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic ICL1 K 66 12x51 s8s9 T 136 N.s8s9.07
Polar H8 Q 314 8x56 s20c E 407 C.s20c.17
Van-der-waals H8 Q 314 8x56 s20c E 407 C.s20c.17
Polar H8 E 306 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic H8 E 306 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 E 306 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 V 139 34x51 S16 Q 248 C.S16.02
Polar ICL2 A 138 34x50 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 A 138 34x50 s5s6 R 65 N.s5s6.02
Hydrophobic TM7 V 304 7x56 s5s6 V 70 N.s5s6.07
Ionic H8 K 310 8x52 s20c D 408 C.s20c.18
Polar TM3 V 136 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 V 136 3x55 s15s16 N 245 C.s15s16.04
Polar ICL2 A 138 34x50 S16 Y 249 C.S16.03
Hydrophobic ICL2 R 145 34x57 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 R 145 34x57 s5s6 R 65 N.s5s6.02
Polar ICL2 R 143 34x55 S16 K 250 C.S16.04
Van-der-waals ICL2 R 143 34x55 S16 K 250 C.S16.04
Hydrophobic TM3 R 131 3x50 s5s6 L 71 N.s5s6.08
Ionic ICL1 K 66 12x51 s20c D 402 C.s20c.12
Polar ICL1 K 66 12x51 s20c D 402 C.s20c.12
Van-der-waals ICL1 K 66 12x51 s20c D 402 C.s20c.12
Ionic ICL2 R 145 34x57 s5s6 D 67 N.s5s6.04
Polar ICL2 R 145 34x57 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 R 145 34x57 s5s6 D 67 N.s5s6.04
Van-der-waals ICL2 R 145 34x57 s5s6 D 67 N.s5s6.04
Polar ICL3 R 229 - s15s16 F 244 C.s15s16.03
Aromatic ICL3 R 229 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL3 R 229 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL3 R 229 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 L 142 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 L 142 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM4 T 146 4x38 s17s18 R 285 C.s17s18.11
Hydrophobic TM6 L 240 6x36 s5s6 L 71 N.s5s6.08
Ionic H8 R 307 8x49 s20c E 404 C.s20c.14
Polar H8 R 307 8x49 s20c E 404 C.s20c.14
Hydrophobic ICL2 L 142 34x54 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 142 34x54 S16 Y 249 C.S16.03
Polar TM4 V 147 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic TM4 V 147 4x39 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 V 147 4x39 s8s9 E 134 N.s8s9.05
Van-der-waals TM1 Y 62 1x60 s20c E 404 C.s20c.14
Hydrophobic ICL2 A 138 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 A 138 34x50 S5 Y 63 N.S5.12
Polar H8 R 307 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic H8 R 307 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 R 307 8x49 s5s6 D 69 N.s5s6.06
Ionic ICL1 R 64 12x49 s20c D 402 C.s20c.12
Polar ICL1 R 64 12x49 s20c D 402 C.s20c.12
Hydrophobic ICL2 V 139 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 V 139 34x51 S16 A 247 C.S16.01
Van-der-waals TM7 I 300 7x52 s5s6 V 70 N.s5s6.07
Polar H8 Y 311 8x53 s20c E 404 C.s20c.14
Hydrophobic H8 Y 311 8x53 s20c E 404 C.s20c.14
Van-der-waals H8 Y 311 8x53 s20c E 404 C.s20c.14
Ionic H8 R 307 8x49 s5s6 E 66 N.s5s6.03
Polar H8 R 307 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic H8 R 307 8x49 s5s6 E 66 N.s5s6.03
Van-der-waals H8 R 307 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic ICL3 R 229 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL3 R 229 - s15s16 N 245 C.s15s16.04
Hydrophobic TM7 Y 301 7x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 Y 301 7x53 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 A 134 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM6 I 241 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 241 6x37 s5s6 L 71 N.s5s6.08
Polar TM3 I 135 3x54 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 I 135 3x54 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 L 226 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 226 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM2 N 67 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM6 L 240 6x36 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 L 240 6x36 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 I 135 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 135 3x54 s5s6 L 73 N.s5s6.10
Polar ICL2 V 139 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 V 139 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 V 139 34x51 S16 Y 249 C.S16.03
Hydrophobic TM3 I 135 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 I 135 3x54 s5s6 L 71 N.s5s6.08
Aromatic ICL3 R 229 - S6 F 75 N.S6.01
Hydrophobic ICL3 R 229 - S6 F 75 N.S6.01
Van-der-waals TM3 R 131 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 I 135 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 I 135 3x54 s5s6 L 68 N.s5s6.05