Gi1 - CCR1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-05-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
CCR1 83.4
Gαi1 88.8
Gβ1 92.5
Gγ2 82.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 11.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 N 67 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 N 67 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL2 V 139 34x51 G.H5 F 336 G.H5.08
Van-der-waals TM6 K 236 6x32 G.H5 F 354 G.H5.26
Aromatic TM6 K 236 6x32 G.H5 F 354 G.H5.26
Polar C-term E 350 - G.H3 S 252 G.H3.11
Van-der-waals C-term E 350 - G.H3 S 252 G.H3.11
Hydrophobic C-term E 350 - G.H3 S 252 G.H3.11
Hydrophobic TM5 L 226 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 226 5x65 G.H5 L 348 G.H5.20
Polar ICL1 K 63 12x48 G.H5 D 350 G.H5.22
Hydrophobic H8 G 305 8x47 G.H5 G 352 G.H5.24
Polar C-term S 352 - G.H2 R 208 G.H2.04
Van-der-waals C-term S 352 - G.H2 R 208 G.H2.04
Hydrophobic TM5 I 225 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 I 225 5x64 G.H5 I 344 G.H5.16
Hydrophobic C-term S 343 - G.H3 W 258 G.H3.17
Van-der-waals C-term S 343 - G.H3 W 258 G.H3.17
Hydrophobic C-term P 344 - G.H3 W 258 G.H3.17
Van-der-waals C-term P 344 - G.H3 W 258 G.H3.17
Hydrophobic ICL2 V 139 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic C-term L 351 - G.H3 I 253 G.H3.12
Van-der-waals C-term L 351 - G.H3 I 253 G.H3.12
Hydrophobic ICL2 L 142 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 142 34x54 G.S3 L 194 G.S3.01
Polar TM3 R 131 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 A 134 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 142 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL2 A 138 34x50 G.H5 T 340 G.H5.12
Polar ICL2 R 143 34x55 G.S3 H 195 G.S3.02
Van-der-waals ICL2 R 143 34x55 G.S3 H 195 G.S3.02
Hydrophobic ICL3 P 230 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 P 230 - G.h4s6 E 318 G.h4s6.12
Ionic ICL2 R 143 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 143 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 143 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 143 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL3 R 229 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 R 229 - G.H5 I 344 G.H5.16
Hydrophobic TM6 I 244 6x40 G.H5 L 353 G.H5.25
Ionic H8 R 307 8x49 G.H5 D 350 G.H5.22
Polar H8 R 307 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 R 307 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 R 307 8x49 G.H5 D 350 G.H5.22
Hydrophobic ICL2 V 139 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 139 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 A 138 34x50 G.H5 I 343 G.H5.15
Hydrophobic C-term H 349 - G.H2 I 212 G.H2.08
Van-der-waals C-term H 349 - G.H2 I 212 G.H2.08
Ionic C-term E 348 - G.H3 K 257 G.H3.16
Polar C-term E 348 - G.H3 K 257 G.H3.16
Hydrophobic C-term E 348 - G.H3 K 257 G.H3.16
Van-der-waals C-term E 348 - G.H3 K 257 G.H3.16
Polar H8 E 306 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 E 306 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 306 8x48 G.H5 F 354 G.H5.26
Hydrophobic C-term L 351 - G.H3 S 252 G.H3.11
Van-der-waals C-term L 351 - G.H3 S 252 G.H3.11
Polar C-term L 351 - G.H3 S 252 G.H3.11
Hydrophobic ICL2 A 138 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 138 34x50 G.H5 I 344 G.H5.16
Polar ICL2 R 143 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 143 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 143 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic C-term L 351 - G.h2s4 F 215 G.h2s4.01
Van-der-waals TM6 A 237 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 135 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 135 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 R 131 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 233 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 233 6x29 G.H5 F 354 G.H5.26
Hydrophobic C-term T 346 - G.H2 I 212 G.H2.08
Van-der-waals C-term T 346 - G.H2 I 212 G.H2.08
Polar TM2 T 69 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 69 2x39 G.H5 C 351 G.H5.23
Polar ICL3 R 229 - G.H5 T 340 G.H5.12
Hydrophobic ICL3 R 229 - G.H5 T 340 G.H5.12
Van-der-waals ICL3 R 229 - G.H5 T 340 G.H5.12
Van-der-waals H8 G 305 8x47 G.H5 F 354 G.H5.26
Hydrophobic H8 G 305 8x47 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 135 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 135 3x54 G.H5 I 344 G.H5.16
Polar ICL2 R 145 34x57 G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 145 34x57 G.H5 C 351 G.H5.23
Van-der-waals TM6 N 231 6x27 G.H5 K 345 G.H5.17
Hydrophobic TM6 L 240 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 135 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 135 3x54 G.H5 L 353 G.H5.25
Van-der-waals ICL2 V 139 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 V 139 34x51 G.s2s3 K 192 G.s2s3.01
Polar ICL2 R 145 34x57 G.H5 N 347 G.H5.19
Van-der-waals ICL2 R 145 34x57 G.H5 N 347 G.H5.19
Polar TM6 N 231 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 N 231 6x27 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 N 231 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 I 241 6x37 G.H5 L 353 G.H5.25
Polar TM3 A 134 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 134 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 N 347 G.H5.19
Hydrophobic C-term A 353 - G.H2 R 205 G.H2.01
Polar C-term A 353 - G.H2 R 205 G.H2.01
Van-der-waals C-term A 353 - G.H2 R 205 G.H2.01
Ionic ICL3 R 229 - G.H5 D 341 G.H5.13
Polar ICL3 R 229 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 229 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 229 - G.H5 D 341 G.H5.13
Polar ICL2 L 142 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 142 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 142 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic C-term P 344 - G.H2 I 212 G.H2.08
Van-der-waals C-term P 344 - G.H2 I 212 G.H2.08
Polar C-term T 346 - G.H2 K 209 G.H2.05
Hydrophobic C-term T 346 - G.H2 K 209 G.H2.05
Van-der-waals C-term T 346 - G.H2 K 209 G.H2.05
Hydrophobic C-term V 339 - G.H3 K 257 G.H3.16
Van-der-waals C-term V 339 - G.H3 K 257 G.H3.16
Polar C-term S 341 - G.H3 W 258 G.H3.17
Hydrophobic C-term S 341 - G.H3 W 258 G.H3.17
Van-der-waals C-term S 341 - G.H3 W 258 G.H3.17
Hydrophobic TM4 T 146 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 T 146 4x38 G.hns1 R 32 G.hns1.03
Polar C-term H 349 - G.H2 R 205 G.H2.01
Hydrophobic C-term H 349 - G.H2 R 205 G.H2.01
Van-der-waals C-term H 349 - G.H2 R 205 G.H2.01
Polar C-term S 352 - G.H3 K 248 G.H3.07
Hydrophobic C-term S 352 - G.H3 K 248 G.H3.07
Van-der-waals C-term S 352 - G.H3 K 248 G.H3.07
Hydrophobic C-term H 349 - G.H3 W 258 G.H3.17
Hydrophobic ICL3 P 230 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 P 230 - G.H5 D 341 G.H5.13
Polar C-term H 349 - G.H3 N 256 G.H3.15
Hydrophobic C-term H 349 - G.H3 N 256 G.H3.15
Van-der-waals C-term H 349 - G.H3 N 256 G.H3.15
Hydrophobic C-term P 344 - G.H3 K 257 G.H3.16
Aromatic C-term F 355 - G.H2 R 205 G.H2.01
Hydrophobic C-term F 355 - G.H2 R 205 G.H2.01
Van-der-waals C-term F 355 - G.H2 R 205 G.H2.01
Hydrophobic C-term S 352 - G.H3 S 252 G.H3.11
Hydrophobic C-term L 351 - G.H3 L 249 G.H3.08
Polar C-term L 351 - G.H3 L 249 G.H3.08
Van-der-waals C-term L 351 - G.H3 L 249 G.H3.08
Polar C-term S 352 - G.H3 E 245 G.H3.04
Hydrophobic C-term S 352 - G.H3 E 245 G.H3.04
Van-der-waals C-term S 352 - G.H3 E 245 G.H3.04
Ionic C-term E 350 - G.h4s6 K 312 G.h4s6.03
Polar C-term E 350 - G.h4s6 K 312 G.h4s6.03
Van-der-waals C-term E 350 - G.h4s6 K 312 G.h4s6.03
Hydrophobic C-term L 351 - G.H2 R 208 G.H2.04
Polar C-term L 351 - G.H2 R 208 G.H2.04
Van-der-waals C-term L 351 - G.H2 R 208 G.H2.04
Polar C-term S 352 - G.H2 R 205 G.H2.01
Polar C-term T 342 - G.H3 K 257 G.H3.16
Hydrophobic C-term T 342 - G.H3 K 257 G.H3.16
Van-der-waals C-term T 342 - G.H3 K 257 G.H3.16
Hydrophobic C-term L 351 - G.H3 K 248 G.H3.07
Van-der-waals C-term L 351 - G.H3 K 248 G.H3.07
Polar TM6 K 233 6x29 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 K 233 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic C-term H 349 - G.H2 K 209 G.H2.05
Hydrophobic C-term S 345 - G.H2 K 209 G.H2.05
Ionic C-term E 337 - G.H3 K 257 G.H3.16
Hydrophobic C-term L 351 - G.H2 I 212 G.H2.08
Van-der-waals C-term L 351 - G.H2 I 212 G.H2.08
Hydrophobic C-term T 342 - G.H3 W 258 G.H3.17
Hydrophobic C-term S 352 - G.s4h3 M 240 G.s4h3.14
Hydrophobic C-term S 345 - G.H3 W 258 G.H3.17
Van-der-waals C-term S 345 - G.H3 W 258 G.H3.17
Hydrophobic TM6 L 240 6x36 G.H5 G 352 G.H5.24
Van-der-waals C-term F 355 - G.H3 K 257 G.H3.16
Ionic C-term H 349 - G.H3 E 245 G.H3.04
Polar C-term H 349 - G.H2 R 208 G.H2.04
Hydrophobic C-term H 349 - G.H2 R 208 G.H2.04
Van-der-waals C-term H 349 - G.H2 R 208 G.H2.04
Hydrophobic H8 R 307 8x49 G.H5 K 349 G.H5.21
Hydrophobic C-term A 353 - G.H3 E 245 G.H3.04
Polar C-term S 352 - G.H3 L 249 G.H3.08
Hydrophobic C-term S 352 - G.H3 L 249 G.H3.08
Hydrophobic C-term L 351 - G.H2 W 211 G.H2.07
Polar C-term P 344 - G.H2 K 209 G.H2.05
Hydrophobic C-term F 355 - G.s3h2 Q 204 G.s3h2.03
Van-der-waals C-term F 355 - G.s3h2 Q 204 G.s3h2.03
Hydrophobic C-term A 353 - G.s4h3 E 236 G.s4h3.10
Van-der-waals C-term A 353 - G.s4h3 E 236 G.s4h3.10
Polar C-term F 355 - G.s4h3 A 235 G.s4h3.09
Hydrophobic C-term F 355 - G.s4h3 A 235 G.s4h3.09
Van-der-waals C-term F 355 - G.s4h3 A 235 G.s4h3.09
Polar C-term T 346 - G.H2 E 207 G.H2.03
Hydrophobic C-term T 346 - G.H2 E 207 G.H2.03
Van-der-waals C-term T 346 - G.H2 E 207 G.H2.03
Hydrophobic C-term G 354 - G.s4h3 L 234 G.s4h3.08
Van-der-waals C-term G 354 - G.s4h3 L 234 G.s4h3.08
Polar C-term G 354 - G.s4h3 E 236 G.s4h3.10
Hydrophobic C-term G 354 - G.s4h3 E 236 G.s4h3.10
Van-der-waals C-term G 354 - G.s4h3 E 236 G.s4h3.10
Polar C-term S 343 - G.H2 K 209 G.H2.05
Hydrophobic C-term S 343 - G.H2 K 209 G.H2.05
Polar C-term F 355 - G.s4h3 E 236 G.s4h3.10
Hydrophobic C-term F 355 - G.s4h3 E 236 G.s4h3.10
Van-der-waals C-term F 355 - G.s4h3 E 236 G.s4h3.10
Hydrophobic C-term L 351 - G.H3 N 256 G.H3.15
Van-der-waals C-term L 351 - G.H3 N 256 G.H3.15
Hydrophobic C-term F 355 - G.H2 K 209 G.H2.05
Hydrophobic C-term E 350 - G.H3 D 251 G.H3.10
Van-der-waals C-term E 350 - G.H3 K 248 G.H3.07