Beta-arrestin-1 - CCR2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
CCR2 74.5
Beta-arrestin-1 79.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 A 145 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 A 145 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 A 145 34x50 S5 Y 63 N.S5.12
Ionic ICL1 K 74 12x51 s20c D 402 C.s20c.12
Polar ICL1 K 74 12x51 s20c D 402 C.s20c.12
Hydrophobic TM6 I 245 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 245 6x37 s5s6 L 71 N.s5s6.08
Polar TM6 K 237 6x29 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 K 237 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic TM3 R 138 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 138 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals ICL1 K 74 12x51 s8s9 E 134 N.s8s9.05
Hydrophobic TM7 Y 305 7x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 Y 305 7x53 s5s6 V 70 N.s5s6.07
Polar TM3 H 144 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 H 144 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 H 144 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 V 146 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 V 146 34x51 S16 A 247 C.S16.01
Hydrophobic TM3 R 138 3x50 s5s6 L 71 N.s5s6.08
Polar TM6 K 237 6x29 s5s6 G 72 N.s5s6.09
Hydrophobic ICL2 L 149 34x54 S8 L 129 N.S8.03
Hydrophobic ICL2 A 145 34x50 s15s16 N 245 C.s15s16.04
Polar ICL2 A 148 34x53 s5s6 R 65 N.s5s6.02
Polar TM3 A 141 3x53 S5 Y 63 N.S5.12
Van-der-waals TM3 A 141 3x53 S5 Y 63 N.S5.12
Polar ICL2 K 150 34x55 S16 Q 248 C.S16.02
Hydrophobic ICL2 K 150 34x55 S16 Q 248 C.S16.02
Van-der-waals ICL2 K 150 34x55 S16 Q 248 C.S16.02
Hydrophobic TM5 T 228 5x64 S6 F 75 N.S6.01
Polar H8 F 312 8x50 s5s6 D 69 N.s5s6.06
Van-der-waals H8 F 312 8x50 s5s6 D 69 N.s5s6.06
Hydrophobic TM6 A 241 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 241 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic H8 G 309 8x47 s5s6 D 69 N.s5s6.06
Ionic ICL2 R 152 34x57 s5s6 D 67 N.s5s6.04
Polar ICL2 R 152 34x57 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 R 152 34x57 s5s6 D 67 N.s5s6.04
Van-der-waals ICL2 R 152 34x57 s5s6 D 67 N.s5s6.04
Hydrophobic TM6 V 244 6x36 s5s6 L 71 N.s5s6.08
Polar ICL2 R 152 34x57 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 R 152 34x57 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 R 152 34x57 s5s6 R 65 N.s5s6.02
Polar TM2 T 77 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 L 149 34x54 S5 Y 63 N.S5.12
Polar ICL2 V 146 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 V 146 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 V 146 34x51 S16 Y 249 C.S16.03
Polar H8 K 311 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic H8 K 311 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 K 311 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 I 142 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 I 142 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 L 149 34x54 S9 C 140 N.S9.01
Hydrophobic TM2 C 75 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 C 75 2x37 s5s6 D 67 N.s5s6.04
Ionic ICL3 R 233 - S6 D 78 N.S6.04
Polar ICL3 R 233 - S6 D 78 N.S6.04
Van-der-waals ICL3 R 233 - S6 D 78 N.S6.04
Polar H8 E 310 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic H8 E 310 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 E 310 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 V 146 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 V 146 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 I 142 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 142 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 I 142 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 I 142 3x54 S6 F 75 N.S6.01
Aromatic ICL2 K 150 34x55 S16 Y 249 C.S16.03
Hydrophobic ICL2 K 150 34x55 S16 Y 249 C.S16.03
Van-der-waals ICL2 K 150 34x55 S16 Y 249 C.S16.03
Hydrophobic ICL2 V 146 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 V 146 34x51 S15 I 241 C.S15.14
Hydrophobic TM6 A 241 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 A 241 6x33 s5s6 L 71 N.s5s6.08
Polar ICL2 L 149 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 L 149 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 L 149 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL1 K 74 12x51 s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 K 74 12x51 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 I 142 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 I 142 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 L 149 34x54 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 149 34x54 S16 Y 249 C.S16.03
Hydrophobic TM5 L 229 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 229 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM7 V 308 7x56 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 A 141 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 A 141 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 L 229 5x65 S6 F 75 N.S6.01
Ionic H8 K 311 8x49 s5s6 E 66 N.s5s6.03
Polar H8 K 311 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic H8 K 311 8x49 s5s6 E 66 N.s5s6.03
Van-der-waals H8 K 311 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic H8 G 309 8x47 s5s6 V 70 N.s5s6.07