Arrestin-C - CCR3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
CCR3 79.0
Arrestin-C 80.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 23.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 P 230 - S6 K 73 N.S6.03
Hydrophobic TM3 I 135 3x54 s5s6 I 67 N.s5s6.08
Hydrophobic TM4 T 146 4x38 s8s9 A 133 N.s8s9.07
Hydrophobic TM3 A 134 3x53 S6 F 71 N.S6.01
Van-der-waals TM3 A 134 3x53 S6 F 71 N.S6.01
Polar ICL2 V 139 34x51 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 V 139 34x51 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 V 139 34x51 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 L 142 34x54 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 L 142 34x54 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 R 145 34x57 s5s6 L 64 N.s5s6.05
Van-der-waals ICL2 R 145 34x57 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 L 142 34x54 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 L 142 34x54 s15s16 S 242 C.s15s16.04
Polar H8 R 307 8x49 s5s6 D 62 N.s5s6.03
Hydrophobic H8 R 307 8x49 s5s6 D 62 N.s5s6.03
Van-der-waals H8 R 307 8x49 s5s6 D 62 N.s5s6.03
Hydrophobic ICL2 L 142 34x54 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 L 142 34x54 s8s9 K 135 N.s8s9.09
Ionic ICL2 R 143 34x55 S16 D 244 C.S16.01
Polar ICL2 R 143 34x55 S16 D 244 C.S16.01
Hydrophobic ICL2 R 143 34x55 S16 D 244 C.S16.01
Van-der-waals ICL2 R 143 34x55 S16 D 244 C.S16.01
Polar ICL2 R 143 34x55 S16 K 245 C.S16.02
Hydrophobic ICL2 R 143 34x55 S16 K 245 C.S16.02
Van-der-waals ICL2 R 143 34x55 S16 K 245 C.S16.02
Hydrophobic TM6 A 237 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 A 237 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic H8 G 305 8x47 s5s6 E 65 N.s5s6.06
Polar ICL2 A 138 34x50 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 A 138 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 A 138 34x50 s15s16 Y 241 C.s15s16.03
Ionic TM6 K 232 6x28 s9s10 E 152 N.s9s10.07
Polar TM6 K 232 6x28 s9s10 E 152 N.s9s10.07
Hydrophobic TM6 K 232 6x28 s9s10 E 152 N.s9s10.07
Van-der-waals TM6 K 232 6x28 s9s10 E 152 N.s9s10.07
Hydrophobic ICL2 A 138 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic TM6 A 237 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 R 131 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 131 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic C-term L 351 - s1s2 N 11 N.s1s2.03
Polar H8 E 306 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic H8 E 306 8x48 s5s6 E 65 N.s5s6.06
Van-der-waals H8 E 306 8x48 s5s6 E 65 N.s5s6.06
Polar ICL1 R 63 12x48 s5s6 D 63 N.s5s6.04
Hydrophobic TM6 L 240 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 L 240 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 I 67 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 I 67 2x37 s5s6 D 63 N.s5s6.04
Polar H8 R 307 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic H8 R 307 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 R 307 8x49 s5s6 E 65 N.s5s6.06
Aromatic ICL2 R 143 34x55 S16 Y 246 C.S16.03
Hydrophobic ICL2 V 139 34x51 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 V 139 34x51 s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 L 142 34x54 S5 Y 59 N.S5.12
Van-der-waals ICL2 L 142 34x54 S5 Y 59 N.S5.12
Hydrophobic TM3 A 134 3x53 s5s6 V 66 N.s5s6.07
Hydrophobic C-term L 351 - s1s2 S 10 N.s1s2.02
Van-der-waals C-term L 351 - s1s2 S 10 N.s1s2.02
Hydrophobic TM6 I 241 6x37 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 L 142 34x54 S16 D 244 C.S16.01
Van-der-waals ICL2 L 142 34x54 S16 D 244 C.S16.01
Hydrophobic ICL3 P 230 - S6 D 74 N.S6.04
Van-der-waals ICL3 P 230 - S6 D 74 N.S6.04
Hydrophobic ICL2 R 143 34x55 s8s9 A 133 N.s8s9.07
Polar ICL2 V 139 34x51 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 V 139 34x51 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 V 139 34x51 s15s16 S 242 C.s15s16.04
Polar TM5 C 229 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 C 229 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 C 229 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 L 142 34x54 s8s9 G 134 N.s8s9.08
Hydrophobic TM3 R 131 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 131 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic C-term L 351 - s9s10 R 158 N.s9s10.13
Hydrophobic TM5 C 229 5x68 S6 K 73 N.S6.03
Ionic H8 R 307 8x49 s5s6 D 63 N.s5s6.04
Polar H8 R 307 8x49 s5s6 D 63 N.s5s6.04
Hydrophobic H8 R 307 8x49 s5s6 D 63 N.s5s6.04
Van-der-waals H8 R 307 8x49 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 I 135 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 I 135 3x54 S6 F 71 N.S6.01
Hydrophobic TM5 L 226 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 L 226 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic TM6 K 233 6x29 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 K 233 6x29 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 V 139 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 V 139 34x51 S16 D 244 C.S16.01