S-arrestin - CCR4 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
CCR4 77.6
S-arrestin 82.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 R 149 34x57 s5s6 Q 73 N.s5s6.02
Van-der-waals ICL2 R 149 34x57 s5s6 Q 73 N.s5s6.02
Hydrophobic TM6 M 243 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 M 243 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 T 228 5x64 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 L 146 34x54 S9 C 147 N.S9.01
Hydrophobic TM5 L 229 5x65 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 A 240 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 A 240 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 A 240 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 240 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 M 131 3x46 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 A 138 3x53 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 A 138 3x53 s5s6 I 76 N.s5s6.05
Hydrophobic TM7 Y 304 7x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 304 7x53 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 I 139 3x54 s5s6 I 76 N.s5s6.05
Hydrophobic ICL2 L 146 34x54 S16 Y 259 C.S16.03
Polar ICL2 R 147 34x55 S16 Y 259 C.S16.03
Aromatic ICL2 R 147 34x55 S16 Y 259 C.S16.03
Hydrophobic ICL2 R 147 34x55 S16 Y 259 C.S16.03
Van-der-waals ICL2 R 147 34x55 S16 Y 259 C.S16.03
Polar TM5 C 232 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 C 232 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 C 232 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 C 232 5x68 S6 F 83 N.S6.01
Van-der-waals TM5 C 232 5x68 S6 F 83 N.S6.01
Hydrophobic TM7 L 307 7x56 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 L 307 7x56 s5s6 V 78 N.s5s6.07
Polar ICL3 N 234 - s5s6 T 82 N.s5s6.11
Hydrophobic ICL3 N 234 - s5s6 T 82 N.s5s6.11
Van-der-waals ICL3 N 234 - s5s6 T 82 N.s5s6.11
Hydrophobic TM3 I 139 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 139 3x54 S6 F 83 N.S6.01
Polar TM3 A 138 3x53 S5 Y 71 N.S5.12
Hydrophobic TM3 A 138 3x53 S5 Y 71 N.S5.12
Van-der-waals TM3 A 138 3x53 S5 Y 71 N.S5.12
Polar H8 G 308 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic H8 G 308 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 G 308 8x47 s5s6 V 78 N.s5s6.07
Ionic ICL3 K 233 - S6 D 86 N.S6.04
Polar ICL3 K 233 - S6 D 86 N.S6.04
Hydrophobic ICL3 K 233 - S6 D 86 N.S6.04
Van-der-waals ICL3 K 233 - S6 D 86 N.S6.04
Van-der-waals TM3 I 139 3x54 s5s6 D 77 N.s5s6.06
Polar ICL3 K 233 - S6 R 84 N.S6.02
Van-der-waals ICL3 K 233 - S6 R 84 N.S6.02
Ionic H8 K 310 8x49 s5s6 E 74 N.s5s6.03
Polar H8 K 310 8x49 s5s6 E 74 N.s5s6.03
Hydrophobic H8 K 310 8x49 s5s6 E 74 N.s5s6.03
Van-der-waals H8 K 310 8x49 s5s6 E 74 N.s5s6.03
Van-der-waals TM6 K 236 6x29 s5s6 G 80 N.s5s6.09
Ionic H8 K 310 8x49 s5s6 D 75 N.s5s6.04
Polar H8 K 310 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 K 310 8x49 s5s6 D 75 N.s5s6.04
Polar ICL2 R 149 34x57 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 149 34x57 s8s9 K 145 N.s8s9.09
Polar ICL2 R 147 34x55 S16 Y 258 C.S16.02
Hydrophobic ICL2 R 147 34x55 S16 Y 258 C.S16.02
Van-der-waals ICL2 R 147 34x55 S16 Y 258 C.S16.02
Ionic TM3 R 135 3x50 s5s6 D 77 N.s5s6.06
Polar TM3 R 135 3x50 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 R 135 3x50 s5s6 D 77 N.s5s6.06
Van-der-waals TM3 R 135 3x50 s5s6 D 77 N.s5s6.06
Hydrophobic ICL2 L 146 34x54 s8s9 K 145 N.s8s9.09
Polar ICL2 S 145 34x53 S5 Y 71 N.S5.12
Van-der-waals ICL2 S 145 34x53 S5 Y 71 N.S5.12
Hydrophobic ICL2 L 146 34x54 S5 Y 71 N.S5.12
Hydrophobic TM5 L 229 5x65 S6 F 83 N.S6.01
Van-der-waals TM5 L 229 5x65 S6 F 83 N.S6.01
Hydrophobic TM6 E 235 6x28 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 E 235 6x28 s9s10 D 166 N.s9s10.08
Polar ICL2 A 142 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 A 142 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 A 142 34x50 S5 Y 71 N.S5.12
Polar ICL2 F 144 34x52 S16 Y 259 C.S16.03
Hydrophobic ICL3 N 234 - s5s6 L 81 N.s5s6.10
Van-der-waals ICL3 N 234 - s5s6 L 81 N.s5s6.10
Polar ICL2 F 144 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 F 144 34x52 S16 D 257 C.S16.01
Hydrophobic TM6 M 243 6x36 s5s6 V 78 N.s5s6.07
Van-der-waals TM6 M 243 6x36 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 135 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 135 3x50 s5s6 V 78 N.s5s6.07
Polar ICL2 V 143 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 V 143 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 V 143 34x51 S16 Y 259 C.S16.03
Ionic TM6 E 235 6x28 S10 R 175 N.S10.03
Hydrophobic TM3 I 139 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic TM7 I 303 7x52 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 I 303 7x52 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 V 143 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 V 143 34x51 S16 D 257 C.S16.01
Hydrophobic ICL2 V 143 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 V 143 34x51 S15 V 251 C.S15.14
Hydrophobic TM6 K 237 6x30 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 I 244 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 K 236 6x29 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 R 135 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 135 3x50 s5s6 I 79 N.s5s6.08