Beta-arrestin-1 - CCR6 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
CCR6 72.2
Beta-arrestin-1 78.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar H8 F 323 8x50 s5s6 D 69 N.s5s6.06
Polar ICL2 R 155 34x55 S16 Y 249 C.S16.03
Hydrophobic ICL2 A 150 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 A 150 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 T 151 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 T 151 34x51 S15 I 241 C.S15.14
Polar ICL2 A 150 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 A 150 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 A 150 34x50 S5 Y 63 N.S5.12
Polar ICL2 T 151 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 T 151 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 T 151 34x51 s15s16 N 245 C.s15s16.04
Polar H8 K 322 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic H8 K 322 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 K 322 8x49 s5s6 D 69 N.s5s6.06
Polar ICL1 R 78 12x51 s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 R 78 12x51 s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 R 78 12x51 s8s9 T 136 N.s8s9.07
Polar ICL2 F 154 34x54 s5s6 R 65 N.s5s6.02
Aromatic ICL2 F 154 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 F 154 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 F 154 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 R 143 3x50 s5s6 L 71 N.s5s6.08
Polar H8 N 325 8x52 s20c E 405 C.s20c.15
Hydrophobic H8 N 325 8x52 s20c E 405 C.s20c.15
Van-der-waals H8 N 325 8x52 s20c E 405 C.s20c.15
Hydrophobic TM3 A 146 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 A 146 3x53 s5s6 L 68 N.s5s6.05
Polar TM3 A 146 3x53 S5 Y 63 N.S5.12
Van-der-waals TM3 A 146 3x53 S5 Y 63 N.S5.12
Ionic H8 K 322 8x49 s5s6 D 67 N.s5s6.04
Polar H8 K 322 8x49 s5s6 D 67 N.s5s6.04
Van-der-waals H8 K 322 8x49 s5s6 D 67 N.s5s6.04
Ionic ICL2 R 157 - s8s9 D 135 N.s8s9.06
Polar ICL2 R 157 - s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 R 157 - s8s9 D 135 N.s8s9.06
Hydrophobic TM6 V 255 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 255 6x36 s5s6 L 71 N.s5s6.08
Ionic ICL1 R 78 12x51 s20c D 402 C.s20c.12
Polar ICL1 R 78 12x51 s20c D 402 C.s20c.12
Van-der-waals ICL3 Q 245 - S6 R 76 N.S6.02
Polar ICL2 T 151 34x51 S16 A 247 C.S16.01
Hydrophobic ICL2 T 151 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 T 151 34x51 S16 A 247 C.S16.01
Hydrophobic TM6 R 249 6x30 s5s6 L 73 N.s5s6.10
Polar ICL2 S 153 34x53 S5 Y 63 N.S5.12
Van-der-waals ICL2 S 153 34x53 S5 Y 63 N.S5.12
Polar C-term Y 352 - s20c K 403 C.s20c.13
Hydrophobic C-term Y 352 - s20c K 403 C.s20c.13
Van-der-waals C-term Y 352 - s20c K 403 C.s20c.13
Hydrophobic H8 G 320 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 G 320 8x47 s5s6 D 69 N.s5s6.06
Ionic TM6 K 248 6x29 s20c E 407 C.s20c.17
Polar TM6 K 248 6x29 s20c E 407 C.s20c.17
Hydrophobic TM5 L 241 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 241 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 K 248 6x29 s5s6 G 72 N.s5s6.09
Van-der-waals ICL2 K 152 34x52 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 L 241 5x65 S6 F 75 N.S6.01
Van-der-waals TM5 L 241 5x65 S6 F 75 N.S6.01
Hydrophobic ICL2 F 154 34x54 S16 Y 249 C.S16.03
Van-der-waals ICL2 F 154 34x54 S16 Y 249 C.S16.03
Hydrophobic TM6 A 252 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 252 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM4 L 161 4x39 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 L 161 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic TM6 A 252 6x33 s5s6 L 71 N.s5s6.08
Polar H8 Q 321 8x48 s20c E 407 C.s20c.17
Hydrophobic H8 Q 321 8x48 s20c E 407 C.s20c.17
Van-der-waals H8 Q 321 8x48 s20c E 407 C.s20c.17
Polar TM3 Q 149 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 Q 149 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 Q 149 3x56 s15s16 N 245 C.s15s16.04
Polar H8 Q 321 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic H8 Q 321 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 Q 321 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 R 143 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 143 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 I 147 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 I 147 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 F 154 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 F 154 34x54 s8s9 D 135 N.s8s9.06
Polar ICL2 T 151 34x51 s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 T 151 34x51 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 T 151 34x51 s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 F 154 34x54 S5 Y 63 N.S5.12
Hydrophobic ICL2 F 154 34x54 s8s9 P 131 N.s8s9.02
Van-der-waals ICL2 F 154 34x54 s8s9 P 131 N.s8s9.02
Hydrophobic TM5 A 244 5x68 S6 F 75 N.S6.01
Hydrophobic TM2 S 79 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 S 79 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 I 147 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic TM7 Y 316 7x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 Y 316 7x53 s5s6 V 70 N.s5s6.07
Ionic H8 K 322 8x49 s5s6 E 66 N.s5s6.03
Polar H8 K 322 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic H8 K 322 8x49 s5s6 E 66 N.s5s6.03
Van-der-waals H8 K 322 8x49 s5s6 E 66 N.s5s6.03
Polar C-term R 351 - s20c Q 414 C.s20c.24
Hydrophobic C-term R 351 - s20c Q 414 C.s20c.24
Van-der-waals C-term R 351 - s20c Q 414 C.s20c.24
Polar ICL2 T 151 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 T 151 34x51 S16 Y 249 C.S16.03
Hydrophobic TM5 A 244 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 R 157 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 R 157 - s5s6 R 65 N.s5s6.02
Polar ICL3 N 246 - s5s6 T 74 N.s5s6.11
Hydrophobic ICL3 N 246 - s5s6 T 74 N.s5s6.11
Van-der-waals ICL3 N 246 - s5s6 T 74 N.s5s6.11
Hydrophobic TM3 I 147 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 I 147 3x54 S6 F 75 N.S6.01
Hydrophobic TM2 T 81 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 T 81 2x39 s5s6 V 70 N.s5s6.07
Ionic ICL2 R 157 - s5s6 D 67 N.s5s6.04
Polar ICL2 R 157 - s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 R 157 - s5s6 D 67 N.s5s6.04
Van-der-waals ICL2 R 157 - s5s6 D 67 N.s5s6.04
Hydrophobic TM6 I 256 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 256 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic H8 G 320 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 I 147 3x54 s5s6 L 73 N.s5s6.10
Polar ICL2 S 153 34x53 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 S 153 34x53 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 S 153 34x53 s5s6 R 65 N.s5s6.02
Hydrophobic TM6 K 248 6x29 s5s6 L 73 N.s5s6.10