ArrestinDb

Arrestin-C - CCR6 complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
CCR6	70.6
Arrestin-C	80.0

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.6

iPTM Score: 0.4

PAE mean: 20.9

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Aromatic	ICL2	F	154	34x54	S16	Y	246	C.S16.03
Hydrophobic	ICL3	N	246	-	S6	R	72	N.S6.02
Hydrophobic	ICL2	F	154	34x54	s8s9	P	128	N.s8s9.02
Hydrophobic	ICL2	T	151	34x51	s15s16	Y	241	C.s15s16.03
Hydrophobic	H8	K	332	8x59	s20c	E	386	C.s20c.20
Hydrophobic	ICL3	N	246	-	s5s6	L	69	N.s5s6.10
Hydrophobic	ICL3	Q	245	-	S6	K	73	N.S6.03
Hydrophobic	H8	K	322	8x49	s5s6	E	65	N.s5s6.06
Hydrophobic	TM3	R	143	3x50	s5s6	I	67	N.s5s6.08
Hydrophobic	TM6	R	249	6x30	s5s6	L	69	N.s5s6.10
Hydrophobic	ICL3	Q	245	-	S6	D	74	N.S6.04
Hydrophobic	TM3	R	143	3x50	s5s6	V	66	N.s5s6.07
Hydrophobic	ICL2	R	157	-	s5s6	L	64	N.s5s6.05
Hydrophobic	ICL2	F	154	34x54	S16	Y	246	C.S16.03
Hydrophobic	H8	K	322	8x49	s5s6	D	62	N.s5s6.03
Hydrophobic	ICL2	F	154	34x54	S16	D	244	C.S16.01
Hydrophobic	TM6	V	255	6x36	s5s6	I	67	N.s5s6.08
Hydrophobic	ICL2	S	158	-	s8s9	D	132	N.s8s9.06
Hydrophobic	ICL2	T	151	34x51	s15s16	L	243	C.s15s16.05
Hydrophobic	H8	K	332	8x59	s20c	G	387	C.s20c.21
Hydrophobic	H8	Q	321	8x48	s5s6	E	65	N.s5s6.06
Hydrophobic	ICL2	F	154	34x54	S5	Y	59	N.S5.12
Hydrophobic	TM3	A	146	3x53	S6	F	71	N.S6.01
Hydrophobic	TM6	A	252	6x33	s5s6	L	69	N.s5s6.10
Hydrophobic	ICL2	F	154	34x54	s8s9	A	133	N.s8s9.07
Hydrophobic	TM5	Y	234	5x58	s5s6	I	67	N.s5s6.08
Hydrophobic	ICL2	F	154	34x54	s8s9	K	135	N.s8s9.09
Hydrophobic	ICL2	R	155	34x55	s8s9	A	133	N.s8s9.07
Hydrophobic	ICL2	T	151	34x51	S16	D	244	C.S16.01
Hydrophobic	H8	K	322	8x49	s5s6	D	63	N.s5s6.04
Hydrophobic	TM5	L	241	5x65	s5s6	L	69	N.s5s6.10
Hydrophobic	ICL2	A	150	34x50	S5	Y	59	N.S5.12
Hydrophobic	ICL2	F	154	34x54	s8s9	G	134	N.s8s9.08
Hydrophobic	ICL2	T	151	34x51	s15s16	S	242	C.s15s16.04
Hydrophobic	TM3	I	147	3x54	S6	F	71	N.S6.01
Hydrophobic	ICL2	F	154	34x54	s8s9	D	132	N.s8s9.06
Hydrophobic	TM6	I	256	6x37	s5s6	I	67	N.s5s6.08
Hydrophobic	TM6	K	248	6x29	s5s6	L	69	N.s5s6.10
Hydrophobic	C-term	Y	352	-	s20c	A	382	C.s20c.15
Hydrophobic	ICL2	A	150	34x50	s15s16	S	242	C.s15s16.04
Hydrophobic	ICL2	A	150	34x50	s15s16	Y	241	C.s15s16.03
Hydrophobic	TM7	I	319	7x56	s5s6	I	67	N.s5s6.08
Hydrophobic	ICL2	S	158	-	s8s9	A	133	N.s8s9.07
Ionic	H8	K	332	8x59	s20c	E	386	C.s20c.20
Ionic	H8	K	322	8x49	s5s6	D	63	N.s5s6.04
Ionic	H8	K	329	8x56	s20c	E	383	C.s20c.17
Polar	ICL3	N	246	-	S6	R	72	N.S6.02
Polar	ICL2	T	151	34x51	s15s16	Y	241	C.s15s16.03
Polar	H8	K	332	8x59	s20c	E	386	C.s20c.20
Polar	ICL2	S	153	34x53	S5	Y	59	N.S5.12
Polar	TM6	S	247	6x28	S6	D	74	N.S6.04
Polar	H8	K	322	8x49	s5s6	E	65	N.s5s6.06
Polar	ICL3	Q	245	-	S6	D	74	N.S6.04
Polar	H8	K	322	8x49	s5s6	D	62	N.s5s6.03
Polar	ICL2	F	154	34x54	S16	D	244	C.S16.01
Polar	ICL2	T	151	34x51	s15s16	L	243	C.s15s16.05
Polar	H8	Q	321	8x48	s5s6	E	65	N.s5s6.06
Polar	ICL2	T	151	34x51	S16	D	244	C.S16.01
Polar	H8	K	322	8x49	s5s6	D	63	N.s5s6.04
Polar	ICL3	N	246	-	s5s6	T	70	N.s5s6.11
Polar	ICL2	A	150	34x50	S5	Y	59	N.S5.12
Polar	H8	K	329	8x56	s20c	E	383	C.s20c.17
Polar	ICL2	R	155	34x55	S16	D	244	C.S16.01
Polar	ICL2	A	150	34x50	s15s16	Y	241	C.s15s16.03
Polar	C-term	N	355	-	s20c	K	378	C.s20c.11
Polar	ICL2	S	158	-	s8s9	A	133	N.s8s9.07
Van-der-waals	ICL3	N	246	-	S6	R	72	N.S6.02
Van-der-waals	ICL2	F	154	34x54	s8s9	P	128	N.s8s9.02
Van-der-waals	ICL2	T	151	34x51	s15s16	Y	241	C.s15s16.03
Van-der-waals	H8	K	332	8x59	s20c	E	386	C.s20c.20
Van-der-waals	ICL3	N	246	-	s5s6	L	69	N.s5s6.10
Van-der-waals	TM6	S	247	6x28	S6	D	74	N.S6.04
Van-der-waals	H8	K	322	8x49	s5s6	E	65	N.s5s6.06
Van-der-waals	TM3	R	143	3x50	s5s6	I	67	N.s5s6.08
Van-der-waals	ICL2	R	157	-	s8s9	K	135	N.s8s9.09
Van-der-waals	ICL3	Q	245	-	S6	D	74	N.S6.04
Van-der-waals	TM3	R	143	3x50	s5s6	V	66	N.s5s6.07
Van-der-waals	ICL2	R	157	-	s5s6	L	64	N.s5s6.05
Van-der-waals	ICL2	F	154	34x54	S16	Y	246	C.S16.03
Van-der-waals	H8	K	322	8x49	s5s6	D	62	N.s5s6.03
Van-der-waals	ICL2	F	154	34x54	S16	D	244	C.S16.01
Van-der-waals	TM6	V	255	6x36	s5s6	I	67	N.s5s6.08
Van-der-waals	ICL2	T	151	34x51	s15s16	L	243	C.s15s16.05
Van-der-waals	H8	K	332	8x59	s20c	G	387	C.s20c.21
Van-der-waals	H8	Q	321	8x48	s5s6	E	65	N.s5s6.06
Van-der-waals	ICL2	F	154	34x54	S5	Y	59	N.S5.12
Van-der-waals	TM3	A	146	3x53	S6	F	71	N.S6.01
Van-der-waals	TM6	A	252	6x33	s5s6	L	69	N.s5s6.10
Van-der-waals	ICL2	F	154	34x54	s8s9	A	133	N.s8s9.07
Van-der-waals	ICL2	F	154	34x54	s8s9	K	135	N.s8s9.09
Van-der-waals	ICL2	T	151	34x51	S16	D	244	C.S16.01
Van-der-waals	H8	K	322	8x49	s5s6	D	63	N.s5s6.04
Van-der-waals	TM5	L	241	5x65	s5s6	L	69	N.s5s6.10
Van-der-waals	ICL2	F	154	34x54	s8s9	G	134	N.s8s9.08
Van-der-waals	ICL2	T	151	34x51	s15s16	S	242	C.s15s16.04
Van-der-waals	TM3	I	147	3x54	S6	F	71	N.S6.01
Van-der-waals	TM6	I	256	6x37	s5s6	I	67	N.s5s6.08
Van-der-waals	H8	K	329	8x56	s20c	E	383	C.s20c.17
Van-der-waals	C-term	Y	352	-	s20c	A	382	C.s20c.15
Van-der-waals	ICL2	A	150	34x50	s15s16	S	242	C.s15s16.04
Van-der-waals	ICL2	A	150	34x50	s15s16	Y	241	C.s15s16.03
Van-der-waals	C-term	N	355	-	s20c	K	378	C.s20c.11
Van-der-waals	ICL2	S	158	-	s8s9	A	133	N.s8s9.07

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Main reference

Arrestin-C - CCR6 complex model Download Full