S-arrestin - CCR6 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
CCR6 73.1
S-arrestin 80.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar C-term Y 352 - s20c D 404 C.s20c.23
Van-der-waals C-term Y 352 - s20c D 404 C.s20c.23
Hydrophobic TM3 I 147 3x54 s5s6 I 76 N.s5s6.05
Hydrophobic H8 L 328 8x55 s20c E 405 C.s20c.24
Van-der-waals H8 L 328 8x55 s20c E 405 C.s20c.24
Polar C-term S 357 - S20 E 381 C.S20.05
Van-der-waals C-term S 357 - S20 E 381 C.S20.05
Hydrophobic TM5 L 241 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 241 5x65 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 V 255 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 V 255 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 I 147 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 147 3x54 S6 F 83 N.S6.01
Polar C-term A 349 - s20c K 397 C.s20c.16
Van-der-waals C-term A 349 - s20c K 397 C.s20c.16
Polar ICL2 T 151 34x51 S16 D 257 C.S16.01
Hydrophobic ICL2 T 151 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 T 151 34x51 S16 D 257 C.S16.01
Hydrophobic TM6 I 256 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 I 256 6x37 s5s6 I 79 N.s5s6.08
Polar ICL2 R 155 34x55 S16 Y 259 C.S16.03
Hydrophobic TM3 R 143 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 143 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 A 150 34x50 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 F 154 34x54 s17s18 G 296 C.s17s18.12
Hydrophobic ICL2 T 151 34x51 S5 Y 71 N.S5.12
Polar TM6 S 247 6x28 s9s10 E 165 N.s9s10.07
Hydrophobic TM6 S 247 6x28 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 S 247 6x28 s9s10 E 165 N.s9s10.07
Ionic H8 K 332 8x59 s20c E 405 C.s20c.24
Polar H8 K 332 8x59 s20c E 405 C.s20c.24
Van-der-waals H8 K 332 8x59 s20c E 405 C.s20c.24
Ionic H8 K 322 8x49 s5s6 D 75 N.s5s6.04
Polar H8 K 322 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic H8 K 322 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 K 322 8x49 s5s6 D 75 N.s5s6.04
Polar ICL2 F 154 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 F 154 34x54 S5 Y 71 N.S5.12
Hydrophobic ICL2 T 151 34x51 s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 A 146 3x53 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 A 146 3x53 s5s6 I 76 N.s5s6.05
Polar ICL2 T 151 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 T 151 34x51 S16 Y 259 C.S16.03
Hydrophobic H8 G 320 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 G 320 8x47 s5s6 D 77 N.s5s6.06
Polar ICL3 N 246 - S6 R 84 N.S6.02
Hydrophobic ICL3 N 246 - S6 R 84 N.S6.02
Van-der-waals ICL3 N 246 - S6 R 84 N.S6.02
Polar ICL3 Q 245 - S6 D 86 N.S6.04
Hydrophobic ICL3 Q 245 - S6 D 86 N.S6.04
Van-der-waals ICL3 Q 245 - S6 D 86 N.S6.04
Aromatic ICL2 F 154 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 F 154 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic TM6 A 252 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 A 252 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 F 154 34x54 s8s9 P 138 N.s8s9.02
Van-der-waals ICL2 F 154 34x54 s8s9 P 138 N.s8s9.02
Polar H8 K 322 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 K 322 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 K 322 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic TM5 L 241 5x65 S6 F 83 N.S6.01
Van-der-waals TM5 L 241 5x65 S6 F 83 N.S6.01
Polar ICL3 N 246 - s5s6 T 82 N.s5s6.11
Van-der-waals ICL3 N 246 - s5s6 T 82 N.s5s6.11
Polar ICL2 A 150 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 A 150 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 A 150 34x50 S5 Y 71 N.S5.12
Polar C-term Y 352 - s20c N 401 C.s20c.20
Hydrophobic TM5 T 240 5x64 s15s16 Y 254 C.s15s16.03
Polar ICL2 K 152 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 K 152 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 K 152 34x52 S16 D 257 C.S16.01
Hydrophobic TM6 A 252 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 252 6x33 s5s6 L 81 N.s5s6.10
Polar TM3 R 143 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 143 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 143 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 R 157 - s5s6 I 76 N.s5s6.05
Hydrophobic TM6 K 248 6x29 s5s6 L 81 N.s5s6.10
Hydrophobic H8 K 329 8x56 s20c R 398 C.s20c.17
Van-der-waals H8 K 329 8x56 s20c R 398 C.s20c.17
Hydrophobic TM3 A 146 3x53 S5 Y 71 N.S5.12
Van-der-waals TM3 A 146 3x53 S5 Y 71 N.S5.12
Hydrophobic TM5 A 244 5x68 S6 R 85 N.S6.03
Hydrophobic ICL2 F 154 34x54 S16 Y 259 C.S16.03
Van-der-waals ICL2 F 154 34x54 S16 Y 259 C.S16.03
Polar ICL2 T 151 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 T 151 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 T 151 34x51 s15s16 S 255 C.s15s16.04
Ionic ICL1 K 76 12x49 s20c D 399 C.s20c.18
Polar ICL1 K 76 12x49 s20c D 399 C.s20c.18
Van-der-waals ICL1 K 76 12x49 s20c D 399 C.s20c.18
Hydrophobic TM2 S 79 2x37 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 S 79 2x37 s5s6 Q 73 N.s5s6.02
Polar ICL2 S 153 34x53 S5 Y 71 N.S5.12
Hydrophobic ICL2 S 153 34x53 S5 Y 71 N.S5.12
Van-der-waals ICL2 S 153 34x53 S5 Y 71 N.S5.12
Hydrophobic TM3 I 147 3x54 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 K 248 6x29 s9s10 D 166 N.s9s10.08
Polar H8 Y 326 8x53 s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 T 151 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 T 151 34x51 S15 V 251 C.S15.14
Hydrophobic ICL1 A 77 12x50 s8s9 Q 141 N.s8s9.05
Van-der-waals ICL1 A 77 12x50 s8s9 Q 141 N.s8s9.05
Hydrophobic C-term T 363 - H1 K 114 N.H1.09
Hydrophobic TM5 T 240 5x64 S6 F 83 N.S6.01
Polar ICL2 R 157 - s5s6 Q 73 N.s5s6.02
Polar H8 Q 321 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic H8 Q 321 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 Q 321 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic TM2 T 81 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 T 81 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 R 157 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 157 - s8s9 K 145 N.s8s9.09
Ionic H8 D 333 8x60 s20c R 398 C.s20c.17