S-arrestin - CCR7 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
CCR7 72.5
S-arrestin 79.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar H8 K 332 8x49 s5s6 D 77 N.s5s6.06
Polar ICL2 H 165 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 H 165 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 H 165 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals TM6 E 257 6x29 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 V 264 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 A 261 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 261 6x33 s5s6 L 81 N.s5s6.10
Polar C-term R 363 - s20c V 403 C.s20c.22
Hydrophobic C-term R 363 - s20c V 403 C.s20c.22
Van-der-waals C-term R 363 - s20c V 403 C.s20c.22
Polar ICL2 S 163 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 S 163 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 S 163 34x52 S16 D 257 C.S16.01
Hydrophobic TM3 I 158 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 V 162 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 V 162 34x51 S15 V 251 C.S15.14
Hydrophobic ICL2 R 168 34x57 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 168 34x57 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 A 161 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 A 161 34x50 S5 Y 71 N.S5.12
Hydrophobic C-term R 363 - s1s2 R 22 N.s1s2.02
Van-der-waals C-term R 363 - s1s2 R 22 N.s1s2.02
Polar ICL3 N 255 - S6 R 84 N.S6.02
Hydrophobic ICL3 N 255 - S6 R 84 N.S6.02
Van-der-waals ICL3 N 255 - S6 R 84 N.S6.02
Hydrophobic TM3 R 154 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 154 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 R 168 34x57 s5s6 Q 73 N.s5s6.02
Van-der-waals ICL2 R 168 34x57 s5s6 Q 73 N.s5s6.02
Hydrophobic ICL2 V 162 34x51 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 I 265 6x37 s5s6 I 79 N.s5s6.08
Polar C-term R 363 - s20c E 405 C.s20c.24
Hydrophobic C-term R 363 - s20c E 405 C.s20c.24
Van-der-waals C-term R 363 - s20c E 405 C.s20c.24
Hydrophobic TM6 F 256 6x28 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 F 256 6x28 s9s10 D 166 N.s9s10.08
Ionic C-term R 353 - s20c E 405 C.s20c.24
Polar C-term R 353 - s20c E 405 C.s20c.24
Hydrophobic C-term R 353 - s20c E 405 C.s20c.24
Van-der-waals C-term R 353 - s20c E 405 C.s20c.24
Polar C-term R 363 - s20c D 402 C.s20c.21
Hydrophobic C-term R 363 - s20c D 402 C.s20c.21
Van-der-waals C-term R 363 - s20c D 402 C.s20c.21
Hydrophobic TM5 L 250 5x65 S6 F 83 N.S6.01
Van-der-waals TM5 L 250 5x65 S6 F 83 N.S6.01
Hydrophobic TM3 I 158 3x54 s5s6 I 76 N.s5s6.05
Hydrophobic TM5 T 249 5x64 s15s16 Y 254 C.s15s16.03
Polar TM6 E 257 6x29 s5s6 T 82 N.s5s6.11
Hydrophobic TM3 R 154 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 154 3x50 s5s6 V 78 N.s5s6.07
Polar ICL3 R 254 - S6 D 86 N.S6.04
Hydrophobic ICL3 R 254 - S6 D 86 N.S6.04
Van-der-waals ICL3 R 254 - S6 D 86 N.S6.04
Ionic ICL2 R 168 34x57 s8s9 D 142 N.s8s9.06
Polar ICL2 R 168 34x57 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 R 168 34x57 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 R 168 34x57 s8s9 D 142 N.s8s9.06
Polar ICL3 N 255 - s5s6 T 82 N.s5s6.11
Van-der-waals ICL3 N 255 - s5s6 T 82 N.s5s6.11
Polar TM3 Q 160 3x56 s15s16 S 255 C.s15s16.04
Van-der-waals TM7 I 329 7x56 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 I 158 3x54 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 V 162 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 V 162 34x51 S16 D 257 C.S16.01
Polar ICL2 V 162 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 V 162 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 V 162 34x51 S16 Y 259 C.S16.03
Polar C-term R 363 - s20c N 401 C.s20c.20
Hydrophobic TM3 A 157 3x53 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 A 157 3x53 s5s6 I 76 N.s5s6.05
Hydrophobic TM3 I 158 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 158 3x54 S6 F 83 N.S6.01
Hydrophobic TM2 T 91 2x37 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 T 91 2x37 s5s6 Q 73 N.s5s6.02
Polar TM3 I 158 3x54 S5 Y 71 N.S5.12
Van-der-waals TM3 I 158 3x54 S5 Y 71 N.S5.12
Polar ICL1 K 90 12x51 s8s9 Q 141 N.s8s9.05
Ionic C-term H 360 - s20c D 402 C.s20c.21
Polar C-term H 360 - s20c D 402 C.s20c.21
Hydrophobic C-term H 360 - s20c D 402 C.s20c.21
Van-der-waals C-term H 360 - s20c D 402 C.s20c.21
Hydrophobic TM6 F 256 6x28 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 F 256 6x28 s9s10 E 165 N.s9s10.07
Hydrophobic TM7 Y 326 7x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 326 7x53 s5s6 V 78 N.s5s6.07
Polar ICL2 H 165 34x54 S16 Y 259 C.S16.03
Aromatic ICL2 H 165 34x54 S16 Y 259 C.S16.03
Hydrophobic ICL2 H 165 34x54 S16 Y 259 C.S16.03
Van-der-waals ICL2 H 165 34x54 S16 Y 259 C.S16.03
Hydrophobic C-term I 361 - s9s10 K 171 N.s9s10.13
Van-der-waals C-term I 361 - s9s10 K 171 N.s9s10.13
Ionic H8 K 332 8x49 s5s6 D 75 N.s5s6.04
Polar H8 K 332 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic H8 K 332 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 K 332 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals C-term R 359 - s9s10 K 170 N.s9s10.12
Polar ICL2 V 162 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 V 162 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 V 162 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 H 165 34x54 S8 L 136 N.S8.03
Van-der-waals ICL2 H 165 34x54 S8 L 136 N.S8.03
Hydrophobic H8 G 330 8x47 s5s6 V 78 N.s5s6.07
Polar ICL2 A 164 34x53 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 A 164 34x53 s8s9 K 145 N.s8s9.09
Ionic ICL2 R 166 34x55 S16 D 257 C.S16.01
Polar ICL2 R 166 34x55 S16 D 257 C.S16.01
Hydrophobic ICL2 R 166 34x55 S16 D 257 C.S16.01
Van-der-waals ICL2 R 166 34x55 S16 D 257 C.S16.01
Hydrophobic H8 G 330 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 G 330 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic TM2 T 93 2x39 s5s6 V 78 N.s5s6.07
Polar ICL2 R 166 34x55 S16 Y 259 C.S16.03
Aromatic ICL2 R 166 34x55 S16 Y 259 C.S16.03
Hydrophobic ICL2 R 166 34x55 S16 Y 259 C.S16.03
Van-der-waals ICL2 R 166 34x55 S16 Y 259 C.S16.03
Polar C-term S 365 - s20c D 404 C.s20c.23
Hydrophobic C-term S 365 - s20c D 404 C.s20c.23
Van-der-waals C-term S 365 - s20c D 404 C.s20c.23
Hydrophobic TM6 A 261 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 T 91 2x37 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 T 91 2x37 s5s6 D 75 N.s5s6.04
Polar C-term H 360 - s20c E 405 C.s20c.24
Polar ICL2 S 163 34x52 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 S 163 34x52 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 S 163 34x52 s15s16 S 255 C.s15s16.04
Hydrophobic TM5 L 250 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 250 5x65 s5s6 L 81 N.s5s6.10
Polar H8 V 331 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic H8 V 331 8x48 s5s6 D 77 N.s5s6.06
Polar ICL2 R 166 34x55 S16 Y 258 C.S16.02
Van-der-waals ICL2 R 166 34x55 S16 Y 258 C.S16.02
Hydrophobic C-term R 363 - s20c D 404 C.s20c.23
Van-der-waals C-term R 363 - s20c D 404 C.s20c.23