Arrestin-C - CCR9 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
CCR9 70.8
Arrestin-C 78.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 K 246 - S6 R 72 N.S6.02
Van-der-waals ICL3 K 246 - S6 R 72 N.S6.02
Hydrophobic TM4 R 158 4x35 s8s9 K 135 N.s8s9.09
Polar H8 G 321 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic H8 G 321 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 G 321 8x47 s5s6 V 66 N.s5s6.07
Polar C-term M 358 - S10 R 162 N.S10.03
Hydrophobic TM3 R 144 3x50 s5s6 I 67 N.s5s6.08
Polar C-term S 357 - S10 R 162 N.S10.03
Hydrophobic C-term S 357 - S10 R 162 N.S10.03
Van-der-waals C-term S 357 - S10 R 162 N.S10.03
Hydrophobic ICL3 K 245 - S6 D 74 N.S6.04
Van-der-waals ICL3 K 245 - S6 D 74 N.S6.04
Hydrophobic TM6 V 255 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 V 255 6x36 s5s6 I 67 N.s5s6.08
Polar C-term S 356 - s9s10 K 157 N.s9s10.12
Van-der-waals C-term S 356 - s9s10 K 157 N.s9s10.12
Ionic C-term E 361 - S1 K 7 N.S1.04
Polar C-term E 361 - S1 K 7 N.S1.04
Hydrophobic C-term E 361 - S1 K 7 N.S1.04
Van-der-waals C-term E 361 - S1 K 7 N.S1.04
Hydrophobic TM6 A 252 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 A 252 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic H8 E 322 8x48 s5s6 G 68 N.s5s6.09
Hydrophobic ICL2 H 155 34x54 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 M 152 34x51 s17s18 E 310 C.s17s18.39
Van-der-waals ICL2 M 152 34x51 s17s18 E 310 C.s17s18.39
Polar TM6 A 252 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 A 252 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 A 252 6x33 s5s6 I 67 N.s5s6.08
Polar ICL2 H 155 34x54 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 H 155 34x54 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 H 155 34x54 s8s9 A 133 N.s8s9.07
Polar ICL2 T 156 34x55 S16 D 244 C.S16.01
Van-der-waals ICL2 T 156 34x55 S16 D 244 C.S16.01
Hydrophobic ICL2 A 151 34x50 s15s16 S 242 C.s15s16.04
Polar TM4 R 158 4x35 s8s9 A 133 N.s8s9.07
Hydrophobic TM4 R 158 4x35 s8s9 A 133 N.s8s9.07
Van-der-waals TM4 R 158 4x35 s8s9 A 133 N.s8s9.07
Hydrophobic TM7 Y 317 7x53 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 Y 317 7x53 s5s6 V 66 N.s5s6.07
Polar ICL2 T 156 34x55 s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 T 156 34x55 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 T 156 34x55 s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 A 151 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 A 151 34x50 s15s16 Y 241 C.s15s16.03
Ionic C-term E 361 - S10 R 162 N.S10.03
Polar C-term E 361 - S10 R 162 N.S10.03
Hydrophobic C-term E 361 - S10 R 162 N.S10.03
Van-der-waals C-term E 361 - S10 R 162 N.S10.03
Polar ICL3 K 246 - S6 F 71 N.S6.01
Hydrophobic ICL3 K 246 - S6 F 71 N.S6.01
Van-der-waals ICL3 K 246 - S6 F 71 N.S6.01
Hydrophobic TM6 K 249 6x30 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 M 152 34x51 s15s16 L 240 C.s15s16.02
Van-der-waals ICL2 M 152 34x51 s15s16 L 240 C.s15s16.02
Hydrophobic C-term M 358 - s17s18 K 291 C.s17s18.20
Van-der-waals C-term M 358 - s17s18 K 291 C.s17s18.20
Ionic H8 R 323 8x49 s5s6 D 63 N.s5s6.04
Polar C-term L 360 - S10 R 162 N.S10.03
Van-der-waals C-term L 360 - S10 R 162 N.S10.03
Polar ICL2 H 155 34x54 s8s9 G 134 N.s8s9.08
Hydrophobic ICL2 H 155 34x54 s8s9 G 134 N.s8s9.08
Van-der-waals ICL2 H 155 34x54 s8s9 G 134 N.s8s9.08
Hydrophobic TM5 L 241 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 L 241 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic TM5 L 241 5x65 S6 F 71 N.S6.01
Ionic ICL2 H 155 34x54 S16 D 244 C.S16.01
Polar ICL2 H 155 34x54 S16 D 244 C.S16.01
Hydrophobic ICL2 H 155 34x54 S16 D 244 C.S16.01
Van-der-waals ICL2 H 155 34x54 S16 D 244 C.S16.01
Ionic H8 R 323 8x49 s5s6 E 65 N.s5s6.06
Polar H8 R 323 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic H8 R 323 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 R 323 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 M 152 34x51 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 M 152 34x51 s15s16 S 242 C.s15s16.04
Polar H8 E 322 8x48 s5s6 E 65 N.s5s6.06
Van-der-waals H8 E 322 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic TM3 I 148 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals ICL1 V 79 12x50 s8s9 P 130 N.s8s9.04
Hydrophobic ICL2 R 153 34x52 s15s16 L 243 C.s15s16.05
Hydrophobic TM2 T 83 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic C-term T 362 - s20c T 369 C.s20c.02
Polar ICL2 A 151 34x50 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 A 151 34x50 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 A 151 34x50 s5s6 R 61 N.s5s6.02
Polar C-term T 362 - s20c Q 377 C.s20c.10
Hydrophobic C-term T 362 - s20c Q 377 C.s20c.10
Polar TM3 A 147 3x53 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 A 147 3x53 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 A 147 3x53 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 A 154 34x53 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 I 148 3x54 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 I 148 3x54 s5s6 L 64 N.s5s6.05
Ionic H8 R 323 8x49 s5s6 D 62 N.s5s6.03
Polar H8 R 323 8x49 s5s6 D 62 N.s5s6.03
Hydrophobic H8 R 323 8x49 s5s6 D 62 N.s5s6.03
Van-der-waals H8 R 323 8x49 s5s6 D 62 N.s5s6.03
Polar ICL3 K 246 - s5s6 T 70 N.s5s6.11
Hydrophobic ICL3 K 246 - s5s6 T 70 N.s5s6.11
Van-der-waals ICL3 K 246 - s5s6 T 70 N.s5s6.11
Hydrophobic ICL2 M 152 34x51 s15s16 V 239 C.s15s16.01
Van-der-waals ICL2 M 152 34x51 s15s16 V 239 C.s15s16.01
Hydrophobic TM3 A 147 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 A 147 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic C-term L 360 - s9s10 K 157 N.s9s10.12
Van-der-waals C-term L 360 - s9s10 K 157 N.s9s10.12
Hydrophobic TM3 R 144 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 144 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 I 148 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 I 148 3x54 S6 F 71 N.S6.01
Hydrophobic TM3 I 148 3x54 s5s6 L 69 N.s5s6.10
Polar ICL2 H 155 34x54 S16 Y 246 C.S16.03
Aromatic ICL2 H 155 34x54 S16 Y 246 C.S16.03
Hydrophobic ICL2 H 155 34x54 S16 Y 246 C.S16.03
Van-der-waals ICL2 H 155 34x54 S16 Y 246 C.S16.03
Polar ICL2 M 152 34x51 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 M 152 34x51 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 M 152 34x51 s15s16 Y 241 C.s15s16.03
Ionic H8 R 326 8x52 s5s6 E 65 N.s5s6.06
Polar H8 R 326 8x52 s5s6 E 65 N.s5s6.06
Hydrophobic H8 R 326 8x52 s5s6 E 65 N.s5s6.06
Van-der-waals H8 R 326 8x52 s5s6 E 65 N.s5s6.06
Polar TM2 T 81 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 T 81 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 T 81 2x37 s5s6 D 63 N.s5s6.04
Polar TM6 S 248 6x29 s5s6 T 70 N.s5s6.11
Hydrophobic H8 G 321 8x47 s5s6 E 65 N.s5s6.06
Polar ICL2 M 152 34x51 s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 M 152 34x51 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 M 152 34x51 s15s16 L 243 C.s15s16.05
Hydrophobic TM6 S 248 6x29 s5s6 L 69 N.s5s6.10
Polar TM4 R 158 4x35 s8s9 G 134 N.s8s9.08