Arrestin-C - CysLT1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
CysLT1 79.7
Arrestin-C 78.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 V 135 34x57 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 I 125 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 I 125 3x54 s5s6 L 69 N.s5s6.10
Ionic ICL3 K 222 - S6 D 74 N.S6.04
Polar ICL3 K 222 - S6 D 74 N.S6.04
Hydrophobic ICL3 K 222 - S6 D 74 N.S6.04
Van-der-waals ICL3 K 222 - S6 D 74 N.S6.04
Hydrophobic TM3 I 125 3x54 S6 F 71 N.S6.01
Polar ICL3 K 222 - S5 T 54 N.S5.07
Hydrophobic ICL3 K 222 - S5 T 54 N.S5.07
Van-der-waals ICL3 K 222 - S5 T 54 N.S5.07
Hydrophobic ICL2 I 132 34x54 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 I 132 34x54 s15s16 Y 241 C.s15s16.03
Hydrophobic H8 G 299 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 V 129 34x51 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 V 129 34x51 s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 I 125 3x54 s5s6 I 67 N.s5s6.08
Polar TM6 K 230 6x33 s5s6 E 65 N.s5s6.06
Van-der-waals TM6 K 230 6x33 s5s6 E 65 N.s5s6.06
Polar ICL2 N 133 34x55 S16 D 244 C.S16.01
Hydrophobic ICL2 N 133 34x55 S16 D 244 C.S16.01
Van-der-waals ICL2 N 133 34x55 S16 D 244 C.S16.01
Polar ICL3 K 223 - s9s10 V 155 N.s9s10.10
Van-der-waals ICL3 K 223 - s9s10 V 155 N.s9s10.10
Polar TM3 R 121 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 R 121 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 121 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 I 132 34x54 S5 Y 59 N.S5.12
Van-der-waals ICL2 I 132 34x54 S5 Y 59 N.S5.12
Hydrophobic H8 G 300 8x48 s5s6 E 65 N.s5s6.06
Van-der-waals H8 G 300 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 I 132 34x54 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 V 129 34x51 s15s16 L 240 C.s15s16.02
Hydrophobic ICL2 I 132 34x54 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 I 132 34x54 s15s16 S 242 C.s15s16.04
Polar ICL2 V 135 34x57 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 V 135 34x57 s5s6 R 61 N.s5s6.02
Ionic H8 K 304 8x52 s20c E 383 C.s20c.17
Polar H8 K 304 8x52 s20c E 383 C.s20c.17
Hydrophobic H8 K 304 8x52 s20c E 383 C.s20c.17
Van-der-waals H8 K 304 8x52 s20c E 383 C.s20c.17
Hydrophobic TM6 K 230 6x33 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 K 230 6x33 s5s6 G 68 N.s5s6.09
Polar ICL2 I 132 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 I 132 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 I 132 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 V 135 34x57 s5s6 L 64 N.s5s6.05
Hydrophobic TM3 A 124 3x53 S6 F 71 N.S6.01
Van-der-waals TM3 A 124 3x53 S6 F 71 N.S6.01
Polar ICL3 K 223 - s9s10 T 154 N.s9s10.09
Hydrophobic ICL3 K 223 - s9s10 T 154 N.s9s10.09
Van-der-waals ICL3 K 223 - s9s10 T 154 N.s9s10.09
Hydrophobic ICL3 K 222 - S5 M 52 N.S5.05
Van-der-waals ICL3 K 222 - S5 M 52 N.S5.05
Hydrophobic TM3 A 124 3x53 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 A 124 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 A 124 3x53 s5s6 L 64 N.s5s6.05
Polar TM2 S 56 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 S 56 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 S 56 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 A 124 3x53 s5s6 I 67 N.s5s6.08
Polar ICL2 Q 130 34x52 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 Q 130 34x52 s15s16 Y 241 C.s15s16.03
Polar TM7 S 298 7x56 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 S 298 7x56 s5s6 V 66 N.s5s6.07
Hydrophobic ICL1 K 55 - s5s6 D 63 N.s5s6.04
Polar TM6 N 224 6x27 s5s6 T 70 N.s5s6.11
Hydrophobic TM6 N 224 6x27 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 N 224 6x27 s5s6 T 70 N.s5s6.11
Polar TM6 S 227 6x30 s5s6 L 69 N.s5s6.10
Hydrophobic TM6 S 227 6x30 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 S 227 6x30 s5s6 L 69 N.s5s6.10
Polar H8 N 301 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 N 301 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic TM2 F 58 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 F 58 2x39 s5s6 V 66 N.s5s6.07
Polar H8 G 300 8x48 s5s6 V 66 N.s5s6.07
Hydrophobic H8 G 300 8x48 s5s6 V 66 N.s5s6.07
Van-der-waals H8 G 300 8x48 s5s6 V 66 N.s5s6.07
Polar TM6 S 227 6x30 s5s6 G 68 N.s5s6.09
Hydrophobic TM6 S 227 6x30 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 S 227 6x30 s5s6 G 68 N.s5s6.09
Hydrophobic ICL2 P 128 34x50 S6 F 71 N.S6.01
Van-der-waals ICL2 P 128 34x50 S6 F 71 N.S6.01
Hydrophobic ICL3 K 222 - S6 V 77 N.S6.07
Van-der-waals ICL3 K 222 - S6 V 77 N.S6.07
Hydrophobic ICL2 N 133 34x55 s15s16 S 242 C.s15s16.04
Ionic ICL1 K 54 - s5s6 D 62 N.s5s6.03
Polar ICL1 K 54 - s5s6 D 62 N.s5s6.03
Hydrophobic ICL1 K 54 - s5s6 D 62 N.s5s6.03
Van-der-waals ICL1 K 54 - s5s6 D 62 N.s5s6.03
Hydrophobic ICL2 P 128 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 P 128 34x50 s15s16 Y 241 C.s15s16.03