S-arrestin - CysLT2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
CysLT2 76.2
S-arrestin 79.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic H8 R 321 8x59 s20c E 405 C.s20c.24
Polar H8 R 321 8x59 s20c E 405 C.s20c.24
Ionic ICL2 H 148 34x55 s8s9 D 142 N.s8s9.06
Polar ICL2 H 148 34x55 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 H 148 34x55 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 H 148 34x55 s8s9 D 142 N.s8s9.06
Hydrophobic ICL1 K 69 - s5s6 Q 73 N.s5s6.02
Van-der-waals ICL1 K 69 - s5s6 Q 73 N.s5s6.02
Van-der-waals TM3 M 140 3x54 s15s16 Y 254 C.s15s16.03
Ionic ICL1 K 68 - s20c E 395 C.s20c.14
Polar ICL1 K 68 - s20c E 395 C.s20c.14
Hydrophobic ICL1 K 68 - s20c E 395 C.s20c.14
Van-der-waals ICL1 K 68 - s20c E 395 C.s20c.14
Polar TM3 R 136 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 R 136 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 136 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic ICL3 P 234 - S6 L 87 N.S6.05
Ionic ICL1 K 69 - s5s6 D 75 N.s5s6.04
Polar ICL1 K 69 - s5s6 D 75 N.s5s6.04
Hydrophobic ICL1 K 69 - s5s6 D 75 N.s5s6.04
Van-der-waals ICL1 K 69 - s5s6 D 75 N.s5s6.04
Hydrophobic ICL1 K 68 - s20c R 398 C.s20c.17
Van-der-waals TM3 V 141 3x55 s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 M 140 3x54 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 M 140 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 F 144 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 F 144 34x51 s15s16 S 255 C.s15s16.04
Polar ICL2 P 143 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 143 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 143 34x50 S5 Y 71 N.S5.12
Ionic TM6 R 243 6x32 s9s10 E 164 N.s9s10.06
Hydrophobic H8 E 310 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic H8 E 310 8x48 s5s6 I 76 N.s5s6.05
Van-der-waals H8 E 310 8x48 s5s6 I 76 N.s5s6.05
Hydrophobic TM2 T 71 2x37 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 A 139 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 A 139 3x53 S6 F 83 N.S6.01
Polar ICL2 F 144 34x51 S5 Y 71 N.S5.12
Aromatic ICL2 F 144 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 F 144 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 F 144 34x51 S5 Y 71 N.S5.12
Hydrophobic TM6 S 241 6x30 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 S 241 6x30 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 F 144 34x51 S9 C 147 N.S9.01
Van-der-waals ICL2 F 144 34x51 S9 C 147 N.S9.01
Polar TM6 S 236 6x25 S6 D 86 N.S6.04
Hydrophobic ICL2 F 144 34x51 S5 F 69 N.S5.10
Hydrophobic ICL2 F 144 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 F 144 34x51 S15 V 251 C.S15.14
Polar TM6 G 237 6x26 S6 D 86 N.S6.04
Hydrophobic TM6 G 237 6x26 S6 D 86 N.S6.04
Van-der-waals TM6 G 237 6x26 S6 D 86 N.S6.04
Hydrophobic ICL2 L 147 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 L 147 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic TM7 A 308 7x56 s5s6 I 79 N.s5s6.08
Polar H8 N 311 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 N 311 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 P 143 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 P 143 34x50 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 L 238 6x27 S6 R 85 N.S6.03
Van-der-waals TM6 L 238 6x27 S6 R 85 N.S6.03
Ionic TM6 K 244 6x33 s5s6 D 77 N.s5s6.06
Polar TM6 K 244 6x33 s5s6 D 77 N.s5s6.06
Hydrophobic TM6 K 244 6x33 s5s6 D 77 N.s5s6.06
Van-der-waals TM6 K 244 6x33 s5s6 D 77 N.s5s6.06
Hydrophobic TM2 T 71 2x37 s5s6 I 76 N.s5s6.05
Van-der-waals TM2 T 71 2x37 s5s6 I 76 N.s5s6.05
Polar ICL2 H 148 34x55 s8s9 K 145 N.s8s9.09
Aromatic ICL2 H 148 34x55 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 H 148 34x55 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 H 148 34x55 s8s9 K 145 N.s8s9.09
Hydrophobic ICL3 P 234 - S6 D 86 N.S6.04
Van-der-waals ICL3 P 234 - S6 D 86 N.S6.04
Polar TM6 K 244 6x33 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 K 244 6x33 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 K 244 6x33 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 V 240 6x29 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 V 240 6x29 s9s10 D 166 N.s9s10.08
Ionic ICL1 K 68 - s5s6 D 75 N.s5s6.04
Polar ICL1 K 68 - s5s6 D 75 N.s5s6.04
Hydrophobic ICL1 K 68 - s5s6 D 75 N.s5s6.04
Van-der-waals ICL1 K 68 - s5s6 D 75 N.s5s6.04
Hydrophobic TM3 M 140 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 M 140 3x54 S6 F 83 N.S6.01
Polar C-term Q 326 - s20c E 405 C.s20c.24
Van-der-waals C-term Q 326 - s20c E 405 C.s20c.24
Hydrophobic TM2 V 73 2x39 s5s6 I 79 N.s5s6.08
Ionic ICL1 K 69 - s20c E 395 C.s20c.14
Polar ICL1 K 69 - s20c E 395 C.s20c.14
Hydrophobic ICL2 F 144 34x51 S16 Y 259 C.S16.03
Hydrophobic TM6 A 245 6x34 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 L 238 6x27 S6 R 84 N.S6.02
Van-der-waals TM6 L 238 6x27 S6 R 84 N.S6.02
Hydrophobic ICL2 F 144 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 F 144 34x51 S16 D 257 C.S16.01
Hydrophobic TM6 S 236 6x25 S6 F 89 N.S6.07
Van-der-waals TM6 S 236 6x25 S6 F 89 N.S6.07
Ionic TM6 R 239 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic TM3 A 139 3x53 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 L 147 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 L 147 34x54 S5 Y 71 N.S5.12
Hydrophobic TM5 V 231 5x68 S6 R 85 N.S6.03
Van-der-waals TM5 V 231 5x68 S6 R 85 N.S6.03
Hydrophobic H8 E 310 8x48 s5s6 V 78 N.s5s6.07
Van-der-waals H8 E 310 8x48 s5s6 V 78 N.s5s6.07
Polar ICL2 F 144 34x51 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 F 144 34x51 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 F 144 34x51 s8s9 K 145 N.s8s9.09
Polar ICL3 E 232 - S6 R 85 N.S6.03
Van-der-waals ICL3 E 232 - S6 R 85 N.S6.03
Ionic ICL2 R 145 34x52 S16 D 257 C.S16.01
Polar ICL2 R 145 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 R 145 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 R 145 34x52 S16 D 257 C.S16.01
Hydrophobic TM2 V 73 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 L 147 34x54 s8s9 G 144 N.s8s9.08
Van-der-waals ICL2 L 147 34x54 s8s9 G 144 N.s8s9.08