Beta-arrestin-1 - chemerin receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
chemerin 75.0
Beta-arrestin-1 80.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 V 145 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 V 145 34x51 S5 Y 63 N.S5.12
Hydrophobic TM5 L 247 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 247 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 I 243 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 I 261 6x36 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 I 261 6x36 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 I 262 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 262 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 V 145 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 V 145 34x51 S16 Y 249 C.S16.03
Hydrophobic TM2 T 72 2x37 s8s9 T 136 N.s8s9.07
Van-der-waals TM2 T 72 2x37 s8s9 T 136 N.s8s9.07
Polar TM3 L 143 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 L 143 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 L 143 3x56 s15s16 N 245 C.s15s16.04
Polar H8 D 322 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic H8 D 322 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 D 322 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 P 144 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 144 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 I 243 5x61 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 R 137 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 137 3x50 s5s6 V 70 N.s5s6.07
Ionic H8 K 325 8x52 s20c E 405 C.s20c.15
Polar H8 K 325 8x52 s20c E 405 C.s20c.15
Hydrophobic H8 K 325 8x52 s20c E 405 C.s20c.15
Van-der-waals H8 K 325 8x52 s20c E 405 C.s20c.15
Hydrophobic ICL2 V 145 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 V 145 34x51 S15 I 241 C.S15.14
Polar TM6 K 257 6x32 s5s6 V 70 N.s5s6.07
Hydrophobic ICL3 L 252 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL3 L 252 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 V 145 34x51 s15s16 N 245 C.s15s16.04
Polar ICL2 Q 148 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 Q 148 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 Q 148 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM6 I 261 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 S 140 3x53 s5s6 L 68 N.s5s6.05
Polar ICL2 Q 148 34x54 S16 Y 249 C.S16.03
Van-der-waals ICL2 Q 148 34x54 S16 Y 249 C.S16.03
Hydrophobic ICL2 P 144 34x50 s15s16 F 244 C.s15s16.03
Polar ICL2 R 151 34x57 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 R 151 34x57 s5s6 R 65 N.s5s6.02
Hydrophobic ICL3 L 252 - S6 F 75 N.S6.01
Van-der-waals ICL3 L 252 - S6 F 75 N.S6.01
Hydrophobic H8 G 320 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic TM5 Y 240 5x58 s5s6 L 71 N.s5s6.08
Hydrophobic TM7 M 319 7x56 s5s6 V 70 N.s5s6.07
Polar ICL2 Q 148 34x54 S5 Y 63 N.S5.12
Van-der-waals ICL2 Q 148 34x54 S5 Y 63 N.S5.12
Hydrophobic TM6 P 258 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 P 258 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic ICL1 K 70 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 K 70 - s8s9 T 136 N.s8s9.07
Polar H8 Q 321 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic H8 Q 321 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 Q 321 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic ICL3 K 254 - S6 R 76 N.S6.02
Hydrophobic TM5 N 250 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 N 250 5x68 s15s16 F 244 C.s15s16.03
Polar ICL2 P 144 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 144 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 144 34x50 S5 Y 63 N.S5.12
Polar TM6 P 258 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 P 258 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 P 258 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 R 137 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 R 137 3x50 s5s6 L 68 N.s5s6.05
Polar ICL2 S 147 34x53 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 S 147 34x53 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 S 147 34x53 s5s6 R 65 N.s5s6.02
Ionic ICL1 K 70 - s20c D 402 C.s20c.12
Polar ICL1 K 70 - s20c D 402 C.s20c.12
Hydrophobic ICL1 K 70 - s20c D 402 C.s20c.12
Van-der-waals ICL1 K 70 - s20c D 402 C.s20c.12
Hydrophobic TM3 V 141 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM7 Y 316 7x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 Y 316 7x53 s5s6 V 70 N.s5s6.07
Hydrophobic TM2 F 78 2x43 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 F 78 2x43 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 V 141 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 V 141 3x54 S6 F 75 N.S6.01
Polar ICL2 N 149 34x55 S16 Y 249 C.S16.03
Hydrophobic ICL2 N 149 34x55 S16 Y 249 C.S16.03
Van-der-waals ICL2 N 149 34x55 S16 Y 249 C.S16.03
Polar TM2 N 74 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 N 74 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 N 74 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 Q 148 34x54 S8 L 129 N.S8.03
Hydrophobic TM3 V 141 3x54 s5s6 L 68 N.s5s6.05
Ionic ICL2 R 151 34x57 s5s6 D 67 N.s5s6.04
Polar ICL2 R 151 34x57 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 R 151 34x57 s5s6 D 67 N.s5s6.04
Van-der-waals ICL2 R 151 34x57 s5s6 D 67 N.s5s6.04
Ionic ICL3 K 254 - S6 D 78 N.S6.04
Polar ICL3 K 254 - S6 D 78 N.S6.04
Van-der-waals ICL3 K 254 - S6 D 78 N.S6.04
Hydrophobic ICL2 V 145 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 V 145 34x51 S16 A 247 C.S16.01
Hydrophobic H8 G 320 8x47 s5s6 V 70 N.s5s6.07