Beta-arrestin-2 - chemerin receptor 2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
chemerin 2 78.2
Beta-arrestin-2 78.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic H8 S 308 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 S 308 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 L 139 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 L 139 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM7 V 305 7x54 s5s6 V 71 N.s5s6.07
Hydrophobic TM2 F 76 2x43 s5s6 D 70 N.s5s6.06
Polar ICL2 R 149 34x57 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 R 149 34x57 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 R 149 34x57 s8s9 T 137 N.s8s9.07
Hydrophobic TM5 Y 226 5x58 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 Y 226 5x58 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 I 238 - S6 F 76 N.S6.01
Van-der-waals ICL3 I 238 - S6 F 76 N.S6.01
Polar H8 K 310 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic H8 K 310 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 K 310 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic TM6 I 248 6x37 s5s6 L 74 N.s5s6.10
Hydrophobic H8 K 310 8x49 s5s6 L 69 N.s5s6.05
Polar H8 S 317 8x56 s20c Y 404 C.s20c.14
Hydrophobic H8 S 317 8x56 s20c Y 404 C.s20c.14
Van-der-waals H8 S 317 8x56 s20c Y 404 C.s20c.14
Hydrophobic TM6 V 251 6x40 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 I 131 3x46 s5s6 L 72 N.s5s6.08
Polar ICL3 L 239 - S6 R 77 N.S6.02
Van-der-waals ICL3 L 239 - S6 R 77 N.S6.02
Hydrophobic TM1 W 67 1x61 s5s6 L 69 N.s5s6.05
Van-der-waals TM1 W 67 1x61 s5s6 L 69 N.s5s6.05
Polar H8 S 308 8x47 s5s6 L 69 N.s5s6.05
Hydrophobic H8 S 308 8x47 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 H 138 3x53 s8s9 K 139 N.s8s9.09
Van-der-waals TM3 H 138 3x53 s8s9 K 139 N.s8s9.09
Polar TM3 H 135 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 H 135 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 H 135 3x50 s5s6 L 72 N.s5s6.08
Ionic H8 K 310 8x49 s5s6 D 68 N.s5s6.04
Polar H8 K 310 8x49 s5s6 D 68 N.s5s6.04
Hydrophobic H8 K 310 8x49 s5s6 D 68 N.s5s6.04
Polar ICL2 P 142 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 P 142 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 P 142 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic TM5 L 229 5x61 s5s6 L 74 N.s5s6.10
Hydrophobic ICL3 L 239 - S6 D 79 N.S6.04
Van-der-waals ICL3 L 239 - S6 D 79 N.S6.04
Hydrophobic TM6 T 247 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 247 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 I 248 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 I 248 6x37 s5s6 L 72 N.s5s6.08
Polar ICL2 V 143 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 V 143 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM7 I 307 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 I 307 7x56 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 H 138 3x53 s8s9 G 138 N.s8s9.08
Ionic ICL1 K 68 - s20c D 402 C.s20c.12
Polar ICL1 K 68 - s20c D 402 C.s20c.12
Van-der-waals ICL1 K 68 - s20c D 402 C.s20c.12
Hydrophobic TM2 T 72 2x39 s5s6 D 70 N.s5s6.06
Hydrophobic TM2 T 72 2x39 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 V 143 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 V 143 34x51 S16 A 248 C.S16.01
Polar TM2 V 71 2x38 s8s9 T 137 N.s8s9.07
Ionic ICL2 H 146 34x54 s8s9 D 136 N.s8s9.06
Polar ICL2 H 146 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 H 146 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 H 146 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL3 I 240 - s5s6 L 74 N.s5s6.10
Van-der-waals ICL3 I 240 - s5s6 L 74 N.s5s6.10
Hydrophobic TM7 L 303 7x52 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 L 303 7x52 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 L 139 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 L 139 3x54 S6 F 76 N.S6.01
Hydrophobic TM2 T 73 2x40 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 L 139 3x54 s8s9 K 139 N.s8s9.09
Van-der-waals TM3 L 139 3x54 s8s9 K 139 N.s8s9.09
Hydrophobic H8 F 311 8x50 s5s6 L 69 N.s5s6.05
Van-der-waals H8 F 311 8x50 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 V 143 34x51 s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 V 143 34x51 s15s16 T 247 C.s15s16.05
Polar TM3 H 138 3x53 S5 Y 64 N.S5.12
Polar TM6 H 244 6x33 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 H 244 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 H 244 6x33 s5s6 G 73 N.s5s6.09
Polar TM3 H 135 3x50 s5s6 G 73 N.s5s6.09
Hydrophobic TM3 H 135 3x50 s5s6 G 73 N.s5s6.09
Van-der-waals TM3 H 135 3x50 s5s6 G 73 N.s5s6.09
Polar TM3 H 135 3x50 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 H 135 3x50 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 F 76 2x43 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 P 142 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 142 34x50 S5 Y 64 N.S5.12
Polar TM3 H 138 3x53 s8s9 T 137 N.s8s9.07
Hydrophobic TM3 H 138 3x53 s8s9 T 137 N.s8s9.07
Van-der-waals TM3 H 138 3x53 s8s9 T 137 N.s8s9.07
Hydrophobic TM6 T 247 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 T 247 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic TM7 Y 304 7x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 Y 304 7x53 s5s6 V 71 N.s5s6.07
Polar TM6 H 244 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 I 238 - S6 R 77 N.S6.02
Van-der-waals ICL3 I 238 - S6 R 77 N.S6.02
Hydrophobic TM4 L 151 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM6 H 244 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 H 244 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 V 233 5x65 S6 F 76 N.S6.01
Van-der-waals TM5 V 233 5x65 S6 F 76 N.S6.01
Polar TM6 H 244 6x33 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 H 244 6x33 s5s6 V 71 N.s5s6.07
Polar TM5 R 236 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 R 236 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 R 236 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM7 Y 304 7x53 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 I 238 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 I 238 - s15s16 F 245 C.s15s16.03
Hydrophobic TM2 T 70 2x37 s8s9 T 137 N.s8s9.07
Van-der-waals TM2 T 70 2x37 s8s9 T 137 N.s8s9.07
Aromatic ICL2 H 146 34x54 S16 Y 250 C.S16.03
Hydrophobic ICL2 H 146 34x54 S16 Y 250 C.S16.03
Van-der-waals ICL2 H 146 34x54 S16 Y 250 C.S16.03
Ionic TM3 H 135 3x50 s5s6 D 70 N.s5s6.06
Polar TM3 H 135 3x50 s5s6 D 70 N.s5s6.06
Hydrophobic TM3 H 135 3x50 s5s6 D 70 N.s5s6.06
Van-der-waals TM3 H 135 3x50 s5s6 D 70 N.s5s6.06