Beta-arrestin-2 - CB1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
CB1 65.4
Beta-arrestin-2 78.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar C-term C 431 - s1s2 C 17 N.s1s2.04
Hydrophobic C-term C 431 - s1s2 C 17 N.s1s2.04
Van-der-waals C-term C 431 - s1s2 C 17 N.s1s2.04
Ionic ICL2 K 225 34x54 s8s9 D 136 N.s8s9.06
Polar ICL2 K 225 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 K 225 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 K 225 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic TM5 M 308 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 M 308 5x72 S6 K 78 N.S6.03
Ionic ICL3 R 331 - S6 D 79 N.S6.04
Polar ICL3 R 331 - S6 D 79 N.S6.04
Van-der-waals ICL3 R 331 - S6 D 79 N.S6.04
Polar ICL3 Q 314 - S6 D 79 N.S6.04
Hydrophobic ICL3 Q 314 - S6 D 79 N.S6.04
Van-der-waals ICL3 Q 314 - S6 D 79 N.S6.04
Ionic H8 K 402 8x48 s5s6 D 70 N.s5s6.06
Polar H8 K 402 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic H8 K 402 8x48 s5s6 D 70 N.s5s6.06
Van-der-waals H8 K 402 8x48 s5s6 D 70 N.s5s6.06
Polar ICL2 L 222 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 222 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 222 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL3 T 313 - S6 L 80 N.S6.05
Van-der-waals ICL3 T 313 - S6 L 80 N.S6.05
Hydrophobic TM3 R 214 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 214 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic ICL3 I 317 - s7s8 P 121 N.s7s8.03
Van-der-waals TM6 Q 334 6x26 S6 D 79 N.S6.04
Hydrophobic ICL2 L 222 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 I 218 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 218 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 M 337 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 M 337 6x29 s5s6 S 75 N.s5s6.11
Polar ICL3 R 331 - S5 T 57 N.S5.05
Aromatic TM5 H 304 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 H 304 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 H 304 5x68 s15s16 F 245 C.s15s16.03
Polar TM6 Q 334 6x26 S6 R 77 N.S6.02
Van-der-waals TM6 Q 334 6x26 S6 R 77 N.S6.02
Hydrophobic TM6 Q 334 6x26 S6 K 78 N.S6.03
Van-der-waals TM6 Q 334 6x26 S6 K 78 N.S6.03
Hydrophobic ICL2 L 222 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 222 34x51 S15 I 242 C.S15.14
Hydrophobic ICL3 I 317 - S6 F 81 N.S6.06
Hydrophobic TM6 L 341 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 L 341 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 I 218 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 218 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 A 301 5x65 s5s6 L 74 N.s5s6.10
Polar ICL2 L 222 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 222 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 222 34x51 S16 Y 250 C.S16.03
Hydrophobic TM6 L 345 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 345 6x37 s5s6 L 72 N.s5s6.08
Polar ICL3 I 317 - S6 I 82 N.S6.07
Hydrophobic TM6 M 337 6x29 S6 F 76 N.S6.01
Hydrophobic TM5 M 308 5x72 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 M 308 5x72 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 M 308 5x72 S6 R 77 N.S6.02
Hydrophobic ICL3 R 331 - S6 I 82 N.S6.07
Van-der-waals ICL3 R 331 - S6 I 82 N.S6.07
Polar C-term D 428 - S20 D 390 C.S20.05
Hydrophobic C-term D 428 - S20 D 390 C.S20.05
Van-der-waals C-term D 428 - S20 D 390 C.S20.05
Hydrophobic TM3 R 214 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 214 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic H8 K 402 8x48 s20c C 409 C.s20c.19
Ionic TM5 R 311 5x75 s17s18 E 314 C.s17s18.39
Polar TM5 R 311 5x75 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 R 311 5x75 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 R 311 5x75 s17s18 E 314 C.s17s18.39
Hydrophobic TM6 L 341 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 341 6x33 s5s6 L 72 N.s5s6.08
Aromatic TM5 H 304 5x68 S6 F 76 N.S6.01
Hydrophobic TM5 H 304 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 H 304 5x68 S6 F 76 N.S6.01
Hydrophobic TM3 I 218 3x54 s5s6 L 72 N.s5s6.08
Polar ICL3 T 313 - S6 K 78 N.S6.03
Hydrophobic ICL3 T 313 - S6 K 78 N.S6.03
Van-der-waals ICL3 T 313 - S6 K 78 N.S6.03
Hydrophobic H8 S 401 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals ICL1 S 146 12x49 s20c Y 404 C.s20c.14
Polar H8 H 406 8x52 s20c Q 407 C.s20c.17
Hydrophobic H8 H 406 8x52 s20c Q 407 C.s20c.17
Van-der-waals H8 H 406 8x52 s20c Q 407 C.s20c.17
Hydrophobic ICL3 T 313 - s17s18 V 315 C.s17s18.40
Van-der-waals ICL3 T 313 - s17s18 V 315 C.s17s18.40
Ionic TM2 R 150 2x37 s5s6 E 67 N.s5s6.03
Polar TM2 R 150 2x37 s5s6 E 67 N.s5s6.03
Hydrophobic TM2 R 150 2x37 s5s6 E 67 N.s5s6.03
Van-der-waals TM2 R 150 2x37 s5s6 E 67 N.s5s6.03
Polar ICL2 P 221 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 221 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 221 34x50 S5 Y 64 N.S5.12
Ionic TM2 R 150 2x37 s5s6 D 68 N.s5s6.04
Polar TM2 R 150 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 R 150 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 R 150 2x37 s5s6 D 68 N.s5s6.04
Polar ICL2 Y 224 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Y 224 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Y 224 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 M 337 6x29 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 M 337 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 Y 153 2x40 s5s6 V 71 N.s5s6.07
Polar TM2 R 150 2x37 s8s9 T 137 N.s8s9.07
Hydrophobic TM2 R 150 2x37 s8s9 T 137 N.s8s9.07
Van-der-waals TM2 R 150 2x37 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 P 221 34x50 s15s16 S 246 C.s15s16.04
Polar ICL3 R 331 - S5 T 59 N.S5.07
Van-der-waals ICL3 R 331 - S5 T 59 N.S5.07
Hydrophobic TM3 S 217 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 S 217 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 I 218 3x54 S6 F 76 N.S6.01
Hydrophobic ICL2 R 226 34x55 S16 Y 250 C.S16.03
Van-der-waals ICL2 R 226 34x55 S16 Y 250 C.S16.03
Polar ICL3 S 316 - S6 I 82 N.S6.07
Hydrophobic ICL3 S 316 - S6 I 82 N.S6.07
Van-der-waals ICL3 S 316 - S6 I 82 N.S6.07
Hydrophobic ICL2 K 225 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 K 225 34x54 s5s6 R 66 N.s5s6.02
Polar TM2 S 152 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 S 152 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 L 222 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 222 34x51 S16 A 248 C.S16.01