Beta-arrestin-1 - CB2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
CB2 77.7
Beta-arrestin-1 80.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM7 Y 299 7x53 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 Y 299 7x53 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 H 219 5x68 s15s16 L 243 C.s15s16.02
Van-der-waals TM5 H 219 5x68 s15s16 L 243 C.s15s16.02
Hydrophobic TM6 L 243 6x33 S6 F 75 N.S6.01
Hydrophobic ICL3 R 236 - S6 K 77 N.S6.03
Hydrophobic ICL2 P 138 34x50 s15s16 F 244 C.s15s16.03
Polar H8 S 308 8x52 s20c E 405 C.s20c.15
Hydrophobic H8 S 308 8x52 s20c E 405 C.s20c.15
Van-der-waals H8 S 308 8x52 s20c E 405 C.s20c.15
Hydrophobic TM6 L 239 6x29 S6 F 75 N.S6.01
Van-der-waals TM6 L 239 6x29 S6 F 75 N.S6.01
Hydrophobic TM6 L 239 6x29 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 L 239 6x29 s5s6 T 74 N.s5s6.11
Polar TM2 Y 70 2x40 s5s6 V 70 N.s5s6.07
Hydrophobic TM2 Y 70 2x40 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 Y 70 2x40 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 A 143 34x55 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 A 143 34x55 s8s9 T 136 N.s8s9.07
Polar TM3 R 131 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 131 3x50 s5s6 V 70 N.s5s6.07
Polar TM7 R 302 7x56 s5s6 G 72 N.s5s6.09
Van-der-waals TM7 R 302 7x56 s5s6 G 72 N.s5s6.09
Hydrophobic TM7 I 298 7x52 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 P 139 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 139 34x51 s15s16 N 245 C.s15s16.04
Polar ICL2 K 142 34x54 s8s9 G 137 N.s8s9.08
Hydrophobic ICL2 K 142 34x54 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 K 142 34x54 s8s9 G 137 N.s8s9.08
Polar ICL2 P 139 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 139 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 139 34x51 S5 Y 63 N.S5.12
Polar TM6 T 246 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 T 246 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 246 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 L 243 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 L 243 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic H8 E 305 8x49 s5s6 D 67 N.s5s6.04
Van-der-waals H8 E 305 8x49 s5s6 D 67 N.s5s6.04
Hydrophobic TM6 D 240 6x30 S6 F 75 N.S6.01
Van-der-waals TM6 D 240 6x30 S6 F 75 N.S6.01
Hydrophobic ICL3 H 226 - s17s18 I 314 C.s17s18.40
Polar TM5 H 219 5x68 s15s16 F 244 C.s15s16.03
Aromatic TM5 H 219 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 H 219 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 H 219 5x68 s15s16 F 244 C.s15s16.03
Polar TM3 R 136 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 R 136 3x55 s15s16 N 245 C.s15s16.04
Polar TM7 R 302 7x56 s5s6 L 71 N.s5s6.08
Hydrophobic TM7 R 302 7x56 s5s6 L 71 N.s5s6.08
Polar TM3 R 131 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 R 131 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 131 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM2 S 69 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 131 3x50 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 R 131 3x50 s5s6 L 73 N.s5s6.10
Polar ICL2 P 138 34x50 s8s9 K 138 N.s8s9.09
Polar ICL2 P 138 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 138 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 138 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 139 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 P 139 34x51 S16 A 247 C.S16.01
Polar ICL3 H 226 - s17s18 N 311 C.s17s18.37
Hydrophobic ICL3 H 226 - s17s18 N 311 C.s17s18.37
Van-der-waals ICL3 H 226 - s17s18 N 311 C.s17s18.37
Hydrophobic ICL3 V 231 - S6 F 80 N.S6.06
Hydrophobic TM6 L 239 6x29 S6 R 76 N.S6.02
Van-der-waals TM6 L 239 6x29 S6 R 76 N.S6.02
Polar TM3 C 134 3x53 s8s9 K 138 N.s8s9.09
Hydrophobic TM3 C 134 3x53 s8s9 K 138 N.s8s9.09
Van-der-waals TM3 C 134 3x53 s8s9 K 138 N.s8s9.09
Polar ICL3 R 236 - S6 D 78 N.S6.04
Hydrophobic ICL3 R 236 - S6 D 78 N.S6.04
Van-der-waals ICL3 R 236 - S6 D 78 N.S6.04
Polar H8 G 304 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 P 138 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 138 34x50 s15s16 N 245 C.s15s16.04
Polar ICL2 K 142 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 K 142 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 K 142 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 K 142 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM5 L 223 5x72 S6 K 77 N.S6.03
Van-der-waals TM5 L 223 5x72 S6 K 77 N.S6.03
Hydrophobic ICL3 A 235 - S6 V 81 N.S6.07
Van-der-waals ICL3 A 235 - S6 V 81 N.S6.07
Hydrophobic TM3 C 134 3x53 s5s6 L 73 N.s5s6.10
Ionic TM6 R 242 6x32 s5s6 D 69 N.s5s6.06
Polar TM6 R 242 6x32 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 L 135 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 L 135 3x54 S6 F 75 N.S6.01
Polar TM3 Y 137 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 Y 137 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 Y 137 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 L 135 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 L 135 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic H8 S 303 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 S 303 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 P 138 34x50 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 P 138 34x50 s8s9 G 137 N.s8s9.08
Polar ICL3 A 235 - S6 D 78 N.S6.04
Hydrophobic ICL3 A 235 - S6 D 78 N.S6.04
Van-der-waals ICL3 A 235 - S6 D 78 N.S6.04
Van-der-waals TM7 R 302 7x56 s5s6 D 69 N.s5s6.06
Polar ICL2 K 142 34x54 s8s9 G 132 N.s8s9.03
Van-der-waals ICL2 K 142 34x54 s8s9 G 132 N.s8s9.03
Polar ICL2 P 139 34x51 s8s9 G 137 N.s8s9.08
Hydrophobic ICL2 P 139 34x51 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 P 139 34x51 s8s9 G 137 N.s8s9.08
Polar ICL2 S 140 34x52 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 S 140 34x52 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 S 140 34x52 s8s9 T 136 N.s8s9.07
Polar ICL2 K 142 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 K 142 34x54 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 K 142 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic TM2 I 73 2x43 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 I 73 2x43 s5s6 V 70 N.s5s6.07
Ionic TM2 K 67 2x37 s5s6 D 67 N.s5s6.04
Polar TM2 K 67 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 K 67 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 K 67 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 K 67 2x37 s5s6 R 65 N.s5s6.02
Polar ICL2 P 139 34x51 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 P 139 34x51 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 P 139 34x51 s8s9 T 136 N.s8s9.07