Beta-arrestin-2 - CRF2 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
CRF2 78.9
Beta-arrestin-2 79.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 209 3x54 s5s6 L 69 N.s5s6.05
Ionic ICL2 E 220 - s17s18 R 286 C.s17s18.11
Polar ICL2 E 220 - s17s18 R 286 C.s17s18.11
Hydrophobic ICL2 E 220 - s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 E 220 - s17s18 R 286 C.s17s18.11
Polar ICL2 T 219 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 T 219 - s5s6 R 66 N.s5s6.02
Aromatic TM5 K 293 5x64 S5 Y 64 N.S5.12
Hydrophobic TM2 C 146 2x44 s8s9 E 135 N.s8s9.05
Van-der-waals TM2 C 146 2x44 s8s9 E 135 N.s8s9.05
Van-der-waals TM5 A 296 5x67 S6 K 78 N.S6.03
Hydrophobic ICL2 Y 217 - S15 I 242 C.S15.14
Van-der-waals ICL2 Y 217 - S15 I 242 C.S15.14
Hydrophobic TM5 A 296 5x67 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 A 296 5x67 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 L 209 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic TM7 Y 359 7x57 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 I 213 3x58 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 213 3x58 s5s6 L 69 N.s5s6.05
Polar TM5 K 293 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 K 293 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 K 293 5x64 s15s16 F 245 C.s15s16.03
Polar TM2 R 148 2x46 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 R 148 2x46 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 R 148 2x46 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 R 148 2x46 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 R 148 2x46 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 Y 217 - S8 L 130 N.S8.03
Van-der-waals ICL2 Y 217 - S8 L 130 N.S8.03
Polar TM2 L 147 2x45 s8s9 E 135 N.s8s9.05
Van-der-waals TM2 L 147 2x45 s8s9 E 135 N.s8s9.05
Polar ICL2 Y 217 - S16 Y 250 C.S16.03
Aromatic ICL2 Y 217 - S16 Y 250 C.S16.03
Hydrophobic ICL2 Y 217 - S16 Y 250 C.S16.03
Van-der-waals ICL2 Y 217 - S16 Y 250 C.S16.03
Hydrophobic TM6 L 315 6x45 s5s6 L 72 N.s5s6.08
Polar TM5 K 293 5x64 s15s16 S 246 C.s15s16.04
Van-der-waals TM5 K 293 5x64 s15s16 S 246 C.s15s16.04
Polar ICL3 T 298 - S6 D 79 N.S6.04
Hydrophobic ICL3 T 298 - S6 D 79 N.S6.04
Van-der-waals ICL3 T 298 - S6 D 79 N.S6.04
Polar ICL2 Y 217 - S9 C 141 N.S9.01
Van-der-waals ICL2 Y 217 - S9 C 141 N.S9.01
Hydrophobic H8 N 363 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 N 363 8x47 s5s6 V 71 N.s5s6.07
Polar ICL2 Y 217 - S5 Y 64 N.S5.12
Hydrophobic ICL2 Y 217 - S5 Y 64 N.S5.12
Van-der-waals ICL2 Y 217 - S5 Y 64 N.S5.12
Polar ICL2 T 216 - S5 Y 64 N.S5.12
Hydrophobic ICL2 T 216 - S5 Y 64 N.S5.12
Van-der-waals ICL2 T 216 - S5 Y 64 N.S5.12
Hydrophobic ICL2 Y 217 - S16 A 248 C.S16.01
Aromatic H8 K 372 8x56 s20c Y 404 C.s20c.14
Ionic TM4 K 224 4x43 s8s9 E 135 N.s8s9.05
Polar TM4 K 224 4x43 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 K 224 4x43 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 K 224 4x43 s8s9 E 135 N.s8s9.05
Polar ICL2 T 216 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 T 216 - s5s6 R 66 N.s5s6.02
Polar TM6 K 307 6x37 s5s6 G 73 N.s5s6.09
Polar H8 K 372 8x56 s20c D 403 C.s20c.13
Hydrophobic H8 K 372 8x56 s20c D 403 C.s20c.13
Van-der-waals H8 K 372 8x56 s20c D 403 C.s20c.13
Hydrophobic TM6 V 314 6x44 s5s6 L 72 N.s5s6.08
Ionic H8 K 372 8x56 s20c D 402 C.s20c.12
Polar ICL2 T 216 - S16 Y 250 C.S16.03
Van-der-waals ICL2 T 216 - S16 Y 250 C.S16.03
Hydrophobic TM5 K 293 5x64 S6 F 76 N.S6.01
Van-der-waals TM5 K 293 5x64 S6 F 76 N.S6.01
Van-der-waals ICL3 S 297 - S6 R 77 N.S6.02
Hydrophobic TM5 L 290 5x61 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 290 5x61 s5s6 L 74 N.s5s6.10
Polar ICL3 T 298 - S6 R 77 N.S6.02
Hydrophobic TM5 L 290 5x61 S6 F 76 N.S6.01
Polar H8 S 368 8x52 s20c Y 404 C.s20c.14
Hydrophobic H8 S 368 8x52 s20c Y 404 C.s20c.14
Van-der-waals H8 S 368 8x52 s20c Y 404 C.s20c.14