S-arrestin - CX3CR1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
CX3CR1 77.7
S-arrestin 80.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 M 138 34x54 S9 C 147 N.S9.01
Van-der-waals ICL2 M 138 34x54 S9 C 147 N.S9.01
Hydrophobic TM7 Y 293 7x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 293 7x53 s5s6 V 78 N.s5s6.07
Hydrophobic H8 R 302 8x52 s20c R 398 C.s20c.17
Van-der-waals H8 R 302 8x52 s20c R 398 C.s20c.17
Hydrophobic TM6 A 229 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 229 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 A 134 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 A 134 34x50 S5 Y 71 N.S5.12
Hydrophobic TM6 A 229 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 A 229 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM7 A 296 7x56 s5s6 V 78 N.s5s6.07
Hydrophobic ICL3 N 223 - s5s6 L 81 N.s5s6.10
Van-der-waals ICL3 N 223 - s5s6 L 81 N.s5s6.10
Hydrophobic TM2 S 64 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic TM5 L 218 5x65 S6 F 83 N.S6.01
Van-der-waals TM5 L 218 5x65 S6 F 83 N.S6.01
Hydrophobic ICL1 P 62 12x50 s8s9 Q 141 N.s8s9.05
Van-der-waals ICL1 P 62 12x50 s8s9 Q 141 N.s8s9.05
Hydrophobic C-term E 328 - s20c E 392 C.s20c.11
Van-der-waals C-term E 328 - s20c E 392 C.s20c.11
Polar H8 G 297 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic H8 G 297 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 G 297 8x47 s5s6 V 78 N.s5s6.07
Polar ICL2 N 136 34x52 s15s16 S 256 C.s15s16.05
Hydrophobic TM3 A 130 3x53 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 A 130 3x53 s5s6 I 76 N.s5s6.05
Hydrophobic ICL2 A 135 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 A 135 34x51 S15 V 251 C.S15.14
Hydrophobic TM3 R 127 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 127 3x50 s5s6 V 78 N.s5s6.07
Polar C-term E 328 - s20c E 394 C.s20c.13
Hydrophobic C-term E 328 - s20c E 394 C.s20c.13
Van-der-waals C-term E 328 - s20c E 394 C.s20c.13
Hydrophobic TM3 I 131 3x54 s5s6 L 81 N.s5s6.10
Polar ICL2 N 136 34x52 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 N 136 34x52 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 N 136 34x52 s15s16 S 255 C.s15s16.04
Hydrophobic TM3 R 127 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 127 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 C 221 5x68 S6 F 83 N.S6.01
Hydrophobic ICL2 M 138 34x54 S8 L 136 N.S8.03
Van-der-waals ICL2 M 138 34x54 S8 L 136 N.S8.03
Polar ICL3 K 222 - S6 R 84 N.S6.02
Hydrophobic ICL3 K 222 - S6 R 84 N.S6.02
Van-der-waals ICL3 K 222 - S6 R 84 N.S6.02
Polar C-term E 328 - s20c A 393 C.s20c.12
Van-der-waals C-term E 328 - s20c A 393 C.s20c.12
Hydrophobic TM3 I 131 3x54 s5s6 I 79 N.s5s6.08
Polar TM3 I 131 3x54 S5 Y 71 N.S5.12
Hydrophobic TM3 I 131 3x54 S5 Y 71 N.S5.12
Van-der-waals TM3 I 131 3x54 S5 Y 71 N.S5.12
Ionic TM6 H 224 6x28 s9s10 E 165 N.s9s10.07
Polar TM6 H 224 6x28 s9s10 E 165 N.s9s10.07
Hydrophobic TM6 H 224 6x28 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 H 224 6x28 s9s10 E 165 N.s9s10.07
Polar TM3 L 133 3x56 s15s16 S 255 C.s15s16.04
Hydrophobic TM3 L 133 3x56 s15s16 S 255 C.s15s16.04
Polar ICL2 M 138 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 M 138 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 M 138 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic C-term S 326 - s20c E 394 C.s20c.13
Polar ICL2 A 135 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 A 135 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 A 135 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 A 135 34x51 S16 D 257 C.S16.01
Polar TM6 H 224 6x28 S6 R 84 N.S6.02
Hydrophobic TM5 L 218 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 218 5x65 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 L 232 6x36 s5s6 V 78 N.s5s6.07
Van-der-waals TM6 L 232 6x36 s5s6 V 78 N.s5s6.07
Polar ICL2 R 141 34x57 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 R 141 34x57 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 141 34x57 s8s9 K 145 N.s8s9.09
Polar ICL2 N 139 34x55 S16 Y 259 C.S16.03
Hydrophobic ICL2 N 139 34x55 S16 Y 259 C.S16.03
Van-der-waals ICL2 N 139 34x55 S16 Y 259 C.S16.03
Polar ICL2 N 136 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 N 136 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 N 136 34x52 S16 D 257 C.S16.01
Hydrophobic TM5 T 217 5x64 s15s16 Y 254 C.s15s16.03
Hydrophobic TM2 L 70 2x43 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 I 131 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 131 3x54 S6 F 83 N.S6.01
Ionic H8 K 299 8x49 s5s6 D 75 N.s5s6.04
Polar H8 K 299 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic TM2 T 66 2x39 s5s6 D 77 N.s5s6.06
Polar ICL2 R 141 34x57 s5s6 Q 73 N.s5s6.02
Van-der-waals ICL2 R 141 34x57 s5s6 Q 73 N.s5s6.02
Ionic TM3 R 127 3x50 s5s6 D 77 N.s5s6.06
Polar TM3 R 127 3x50 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 R 127 3x50 s5s6 D 77 N.s5s6.06
Van-der-waals TM3 R 127 3x50 s5s6 D 77 N.s5s6.06
Polar TM5 C 221 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 C 221 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 C 221 5x68 s15s16 Y 254 C.s15s16.03
Polar ICL2 A 135 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 A 135 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 A 135 34x51 s15s16 S 255 C.s15s16.04
Ionic ICL3 K 222 - S6 D 86 N.S6.04
Polar ICL3 K 222 - S6 D 86 N.S6.04
Hydrophobic ICL3 K 222 - S6 D 86 N.S6.04
Van-der-waals ICL3 K 222 - S6 D 86 N.S6.04
Van-der-waals TM6 K 225 6x29 s5s6 G 80 N.s5s6.09
Polar ICL3 N 223 - s5s6 T 82 N.s5s6.11
Hydrophobic ICL3 N 223 - s5s6 T 82 N.s5s6.11
Van-der-waals ICL3 N 223 - s5s6 T 82 N.s5s6.11
Polar C-term S 327 - s20c E 394 C.s20c.13
Van-der-waals C-term S 327 - s20c E 394 C.s20c.13
Polar ICL2 M 138 34x54 S16 Y 259 C.S16.03
Hydrophobic ICL2 M 138 34x54 S16 Y 259 C.S16.03
Van-der-waals ICL2 M 138 34x54 S16 Y 259 C.S16.03
Hydrophobic TM6 L 232 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 232 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 I 233 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic TM7 I 292 7x52 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 I 292 7x52 s5s6 V 78 N.s5s6.07
Hydrophobic TM7 A 294 7x54 s5s6 V 78 N.s5s6.07
Ionic TM6 H 224 6x28 s9s10 D 166 N.s9s10.08
Polar TM6 H 224 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 H 224 6x28 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 H 224 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic TM3 I 131 3x54 s5s6 I 76 N.s5s6.05