Beta-arrestin-1 - CXCR2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
CXCR2 76.0
Beta-arrestin-1 79.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Van-der-waals TM3 H 150 3x56 s15s16 F 244 C.s15s16.03
Polar ICL2 R 153 34x52 S16 Y 249 C.S16.03
Hydrophobic ICL2 R 153 34x52 S16 Y 249 C.S16.03
Van-der-waals ICL2 R 153 34x52 S16 Y 249 C.S16.03
Hydrophobic ICL2 R 159 34x58 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 R 159 34x58 s8s9 T 136 N.s8s9.07
Hydrophobic TM7 Y 314 7x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 Y 314 7x53 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 I 253 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 253 6x37 s5s6 L 71 N.s5s6.08
Polar TM6 Q 245 6x29 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 Q 245 6x29 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 Q 245 6x29 s5s6 G 72 N.s5s6.09
Polar ICL2 A 151 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 A 151 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 A 151 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic ICL3 M 243 - S6 F 75 N.S6.01
Van-der-waals ICL3 M 243 - S6 F 75 N.S6.01
Polar TM2 V 82 2x38 s5s6 D 67 N.s5s6.04
Hydrophobic ICL3 M 243 - s5s6 L 73 N.s5s6.10
Hydrophobic H8 G 318 8x47 s5s6 V 70 N.s5s6.07
Polar TM2 T 83 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 T 83 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic H8 G 318 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 I 148 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 I 148 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic TM3 I 148 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 I 148 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 Q 245 6x29 s5s6 L 73 N.s5s6.10
Ionic H8 K 320 8x49 s5s6 E 66 N.s5s6.03
Polar H8 K 320 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic H8 K 320 8x49 s5s6 E 66 N.s5s6.03
Van-der-waals H8 K 320 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic TM3 R 144 3x50 s5s6 L 71 N.s5s6.08
Polar ICL2 R 159 34x58 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 R 159 34x58 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 R 159 34x58 s8s9 E 134 N.s8s9.05
Polar TM6 A 249 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 A 249 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 A 249 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 M 243 - s5s6 T 74 N.s5s6.11
Van-der-waals ICL3 M 243 - s5s6 T 74 N.s5s6.11
Hydrophobic TM6 A 249 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 249 6x33 s5s6 L 73 N.s5s6.10
Polar ICL2 R 153 34x52 S5 Y 63 N.S5.12
Hydrophobic ICL2 R 153 34x52 S5 Y 63 N.S5.12
Van-der-waals ICL2 R 153 34x52 S5 Y 63 N.S5.12
Hydrophobic ICL2 T 156 34x55 s5s6 R 65 N.s5s6.02
Ionic H8 K 320 8x49 s5s6 D 69 N.s5s6.06
Polar H8 K 320 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic H8 K 320 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 K 320 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic C-term P 346 - s20c R 395 C.s20c.05
Hydrophobic ICL2 R 153 34x52 S16 A 247 C.S16.01
Polar C-term P 341 - s20c K 403 C.s20c.13
Hydrophobic ICL2 T 152 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 T 152 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 I 148 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 I 148 3x54 S6 F 75 N.S6.01
Polar ICL2 T 152 34x51 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 T 152 34x51 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 T 152 34x51 s5s6 R 65 N.s5s6.02
Hydrophobic TM2 T 83 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals ICL3 H 242 - S6 R 76 N.S6.02
Hydrophobic TM3 I 148 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 148 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 V 252 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic ICL1 V 78 12x49 s8s9 P 133 N.s8s9.04
Hydrophobic TM3 R 144 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 144 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 R 159 34x58 s8s9 D 135 N.s8s9.06
Polar ICL2 R 159 34x58 s8s9 P 133 N.s8s9.04
Hydrophobic ICL2 R 153 34x52 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 R 153 34x52 s8s9 G 137 N.s8s9.08
Hydrophobic TM3 A 147 3x53 s5s6 L 68 N.s5s6.05
Polar TM6 Q 245 6x29 s20c E 407 C.s20c.17
Polar ICL2 Q 157 34x56 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 A 151 34x50 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 A 151 34x50 s15s16 F 244 C.s15s16.03
Polar ICL2 T 156 34x55 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 T 156 34x55 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 T 156 34x55 s8s9 T 136 N.s8s9.07
Ionic C-term D 343 - s20c K 403 C.s20c.13
Polar C-term D 343 - s20c K 403 C.s20c.13
Hydrophobic C-term D 343 - s20c K 403 C.s20c.13
Van-der-waals C-term D 343 - s20c K 403 C.s20c.13
Hydrophobic TM3 A 147 3x53 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 A 147 3x53 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 R 153 34x52 S15 I 241 C.S15.14
Van-der-waals ICL1 G 79 12x50 s5s6 E 66 N.s5s6.03
Hydrophobic TM6 K 246 6x30 s5s6 L 73 N.s5s6.10
Polar H8 Q 319 8x48 s5s6 D 69 N.s5s6.06
Polar ICL2 A 151 34x50 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 A 151 34x50 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 A 151 34x50 s5s6 R 65 N.s5s6.02
Hydrophobic TM5 L 238 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 238 5x65 s5s6 L 73 N.s5s6.10
Polar ICL2 R 153 34x52 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 R 153 34x52 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 R 153 34x52 s15s16 N 245 C.s15s16.04
Polar ICL2 R 153 34x52 s8s9 K 138 N.s8s9.09
Van-der-waals ICL2 R 153 34x52 s8s9 K 138 N.s8s9.09
Hydrophobic TM2 S 81 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 S 81 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 R 153 34x52 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 R 153 34x52 s5s6 R 65 N.s5s6.02