Beta-arrestin-2 - CXCR3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
CXCR3 75.2
Beta-arrestin-2 79.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 Y 160 34x54 S8 L 130 N.S8.03
Van-der-waals ICL2 Y 160 34x54 S8 L 130 N.S8.03
Polar TM3 I 153 3x54 S5 Y 64 N.S5.12
Hydrophobic TM3 I 153 3x54 S5 Y 64 N.S5.12
Van-der-waals TM3 I 153 3x54 S5 Y 64 N.S5.12
Polar TM3 N 152 3x53 S5 Y 64 N.S5.12
Van-der-waals TM3 N 152 3x53 S5 Y 64 N.S5.12
Hydrophobic ICL2 Y 160 34x54 s8s9 Q 131 N.s8s9.01
Hydrophobic TM3 I 153 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 153 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 Y 160 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 Y 160 34x54 s8s9 D 136 N.s8s9.06
Polar ICL2 Q 158 34x52 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 Q 158 34x52 s15s16 S 246 C.s15s16.04
Hydrophobic TM2 T 88 2x39 s5s6 V 71 N.s5s6.07
Polar ICL2 Q 158 34x52 s15s16 T 247 C.s15s16.05
Polar ICL2 Q 158 34x52 S16 Y 250 C.S16.03
Van-der-waals ICL2 Q 158 34x52 S16 Y 250 C.S16.03
Polar H8 K 324 8x49 s8s9 T 137 N.s8s9.07
Van-der-waals H8 K 324 8x49 s8s9 T 137 N.s8s9.07
Hydrophobic TM3 I 153 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 153 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic H8 G 322 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic ICL1 A 84 12x50 s8s9 E 135 N.s8s9.05
Hydrophobic TM7 Y 318 7x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 Y 318 7x53 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 A 253 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 253 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 I 153 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 I 153 3x54 S6 F 76 N.S6.01
Polar ICL2 T 157 34x51 S16 A 248 C.S16.01
Hydrophobic ICL2 T 157 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 T 157 34x51 S16 A 248 C.S16.01
Polar ICL2 L 159 34x53 S16 Y 250 C.S16.03
Hydrophobic ICL2 T 157 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 A 156 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 A 156 34x50 S5 Y 64 N.S5.12
Hydrophobic TM5 S 245 5x68 S6 F 76 N.S6.01
Polar TM2 S 86 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 S 86 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 S 86 2x37 s5s6 D 68 N.s5s6.04
Polar TM3 V 154 3x55 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 Q 158 34x52 S16 A 248 C.S16.01
Van-der-waals ICL2 Q 158 34x52 S16 A 248 C.S16.01
Hydrophobic TM3 I 153 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 153 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 R 250 6x30 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 A 253 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 A 253 6x33 s5s6 L 72 N.s5s6.08
Polar H8 V 323 8x48 s5s6 D 70 N.s5s6.06
Ionic H8 K 324 8x49 s5s6 E 67 N.s5s6.03
Polar H8 K 324 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic H8 K 324 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 K 324 8x49 s5s6 E 67 N.s5s6.03
Polar ICL2 L 159 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 159 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 L 159 34x53 s5s6 R 66 N.s5s6.02
Ionic H8 K 324 8x49 s5s6 D 70 N.s5s6.06
Polar H8 K 324 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic H8 K 324 8x49 s5s6 D 70 N.s5s6.06
Van-der-waals H8 K 324 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic TM5 L 242 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 242 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 V 257 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 L 242 5x65 S6 F 76 N.S6.01
Hydrophobic TM5 V 241 5x64 S6 F 76 N.S6.01
Van-der-waals TM5 V 241 5x64 S6 F 76 N.S6.01
Hydrophobic TM3 N 152 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 N 152 3x53 s5s6 L 69 N.s5s6.05
Polar ICL2 T 157 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 T 157 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 Y 160 34x54 s8s9 P 132 N.s8s9.02
Van-der-waals ICL2 Y 160 34x54 s8s9 P 132 N.s8s9.02
Polar ICL3 R 246 - S6 R 77 N.S6.02
Polar ICL2 R 161 34x55 S16 Q 249 C.S16.02
Hydrophobic ICL2 R 161 34x55 S16 Q 249 C.S16.02
Van-der-waals ICL2 R 161 34x55 S16 Q 249 C.S16.02
Hydrophobic H8 G 322 8x47 s5s6 D 70 N.s5s6.06
Polar ICL2 T 157 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 T 157 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 T 157 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 R 149 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 149 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 Y 160 34x54 s8s9 A 140 N.s8s9.10
Van-der-waals ICL2 Y 160 34x54 s8s9 A 140 N.s8s9.10
Polar ICL2 Y 160 34x54 S9 C 141 N.S9.01
Hydrophobic ICL2 Y 160 34x54 S9 C 141 N.S9.01
Polar ICL2 R 161 34x55 S16 Y 250 C.S16.03
Aromatic ICL2 R 161 34x55 S16 Y 250 C.S16.03
Hydrophobic ICL2 R 161 34x55 S16 Y 250 C.S16.03
Van-der-waals ICL2 R 161 34x55 S16 Y 250 C.S16.03
Hydrophobic TM6 L 256 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 256 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 T 157 34x51 S5 F 62 N.S5.10
Hydrophobic ICL2 T 157 34x51 S9 C 141 N.S9.01
Hydrophobic ICL2 T 157 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 T 157 34x51 S15 I 242 C.S15.14
Hydrophobic TM3 R 149 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 L 256 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 L 256 6x36 s5s6 V 71 N.s5s6.07
Polar ICL2 Y 160 34x54 S16 Y 250 C.S16.03
Hydrophobic ICL2 Y 160 34x54 S16 Y 250 C.S16.03
Van-der-waals ICL2 Y 160 34x54 S16 Y 250 C.S16.03