S-arrestin - CXCR5 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
CXCR5 71.2
S-arrestin 77.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar C-term S 358 - s9s10 K 170 N.s9s10.12
Hydrophobic C-term S 358 - s9s10 K 170 N.s9s10.12
Van-der-waals C-term S 358 - s9s10 K 170 N.s9s10.12
Polar C-term S 368 - S20 E 381 C.S20.05
Polar ICL3 R 250 - S6 F 89 N.S6.07
Van-der-waals ICL3 R 250 - S6 F 89 N.S6.07
Polar ICL2 Y 158 34x54 s8s9 Q 137 N.s8s9.01
Hydrophobic TM6 A 257 6x33 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 A 257 6x33 s5s6 G 80 N.s5s6.09
Hydrophobic TM3 R 147 3x50 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 R 147 3x50 s5s6 I 76 N.s5s6.05
Polar TM3 H 153 3x56 s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 H 153 3x56 s15s16 Y 254 C.s15s16.03
Van-der-waals TM3 H 153 3x56 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 L 245 5x65 S6 F 83 N.S6.01
Van-der-waals TM5 L 245 5x65 S6 F 83 N.S6.01
Ionic ICL3 R 251 - S6 D 86 N.S6.04
Polar ICL3 R 251 - S6 D 86 N.S6.04
Hydrophobic ICL3 R 251 - S6 D 86 N.S6.04
Van-der-waals ICL3 R 251 - S6 D 86 N.S6.04
Hydrophobic ICL2 V 155 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 V 155 34x51 S16 D 257 C.S16.01
Hydrophobic TM6 R 254 6x30 S6 R 85 N.S6.03
Van-der-waals TM6 R 254 6x30 S6 R 85 N.S6.03
Hydrophobic TM3 I 143 3x46 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 S 84 2x37 s5s6 I 76 N.s5s6.05
Van-der-waals TM2 S 84 2x37 s5s6 I 76 N.s5s6.05
Polar ICL2 R 161 34x57 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 R 161 34x57 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 161 34x57 s8s9 K 145 N.s8s9.09
Ionic ICL3 R 251 - S9 E 152 N.S9.06
Polar ICL3 R 251 - S9 E 152 N.S9.06
Van-der-waals ICL3 R 251 - S9 E 152 N.S9.06
Polar ICL3 R 251 - S5 T 66 N.S5.07
Hydrophobic ICL3 R 251 - S5 T 66 N.S5.07
Van-der-waals ICL3 R 251 - S5 T 66 N.S5.07
Polar H8 K 328 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic H8 K 328 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 K 328 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic TM3 H 153 3x56 s15s16 S 255 C.s15s16.04
Hydrophobic C-term N 365 - S1 K 19 N.S1.04
Van-der-waals C-term N 365 - S1 K 19 N.S1.04
Polar ICL1 T 82 12x50 s5s6 Q 73 N.s5s6.02
Van-der-waals ICL1 T 82 12x50 s5s6 Q 73 N.s5s6.02
Hydrophobic TM2 L 90 2x43 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 L 90 2x43 s5s6 V 78 N.s5s6.07
Polar ICL2 H 156 34x52 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 H 156 34x52 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 H 156 34x52 s15s16 S 255 C.s15s16.04
Polar ICL2 R 159 34x55 S16 Y 258 C.S16.02
Van-der-waals ICL2 R 159 34x55 S16 Y 258 C.S16.02
Hydrophobic TM2 T 86 2x39 s5s6 I 79 N.s5s6.08
Van-der-waals TM2 T 86 2x39 s5s6 I 79 N.s5s6.08
Aromatic TM6 R 254 6x30 S6 F 83 N.S6.01
Hydrophobic TM6 R 254 6x30 S6 F 83 N.S6.01
Polar ICL2 A 154 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 A 154 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 A 154 34x50 S5 Y 71 N.S5.12
Ionic TM6 K 256 6x32 s9s10 D 166 N.s9s10.08
Hydrophobic TM3 I 151 3x54 s15s16 Y 254 C.s15s16.03
Van-der-waals TM3 I 151 3x54 s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 I 151 3x54 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 I 151 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 V 260 6x36 s5s6 I 79 N.s5s6.08
Polar C-term T 367 - S20 E 381 C.S20.05
Hydrophobic C-term T 367 - S20 E 381 C.S20.05
Van-der-waals C-term T 367 - S20 E 381 C.S20.05
Polar ICL2 V 155 34x51 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 V 155 34x51 s15s16 Y 254 C.s15s16.03
Ionic TM6 R 254 6x30 S6 D 86 N.S6.04
Polar TM6 R 254 6x30 S6 D 86 N.S6.04
Van-der-waals TM6 R 254 6x30 S6 D 86 N.S6.04
Hydrophobic TM2 L 90 2x43 s5s6 I 79 N.s5s6.08
Ionic ICL3 R 251 - s9s10 E 165 N.s9s10.07
Polar ICL3 R 251 - s9s10 E 165 N.s9s10.07
Hydrophobic ICL3 R 251 - s9s10 E 165 N.s9s10.07
Van-der-waals ICL3 R 251 - s9s10 E 165 N.s9s10.07
Polar ICL2 R 159 34x55 S16 Y 259 C.S16.03
Aromatic ICL2 R 159 34x55 S16 Y 259 C.S16.03
Hydrophobic ICL2 R 159 34x55 S16 Y 259 C.S16.03
Van-der-waals ICL2 R 159 34x55 S16 Y 259 C.S16.03
Polar ICL2 R 159 34x55 S16 D 257 C.S16.01
Hydrophobic ICL2 R 159 34x55 S16 D 257 C.S16.01
Van-der-waals ICL2 R 159 34x55 S16 D 257 C.S16.01
Hydrophobic ICL2 Y 158 34x54 S8 L 136 N.S8.03
Van-der-waals ICL2 Y 158 34x54 S8 L 136 N.S8.03
Hydrophobic TM3 R 147 3x50 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 R 147 3x50 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 V 258 6x34 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 V 258 6x34 s5s6 L 81 N.s5s6.10
Hydrophobic H8 F 329 8x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 V 152 3x55 s15s16 Y 254 C.s15s16.03
Polar ICL2 A 154 34x50 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 A 154 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 A 154 34x50 s15s16 Y 254 C.s15s16.03
Hydrophobic TM2 E 87 2x40 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 E 87 2x40 s5s6 V 78 N.s5s6.07
Polar ICL2 Y 158 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 Y 158 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 Y 158 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 V 155 34x51 s15s16 S 256 C.s15s16.05
Polar ICL2 Y 158 34x54 S5 Y 71 N.S5.12
Hydrophobic ICL2 Y 158 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 Y 158 34x54 S5 Y 71 N.S5.12
Hydrophobic ICL3 P 252 - s9s10 D 166 N.s9s10.08
Van-der-waals ICL3 P 252 - s9s10 D 166 N.s9s10.08
Polar TM6 R 254 6x30 S6 R 84 N.S6.02
Hydrophobic TM6 R 254 6x30 S6 R 84 N.S6.02
Van-der-waals TM6 R 254 6x30 S6 R 84 N.S6.02
Hydrophobic C-term N 365 - S20 E 381 C.S20.05
Van-der-waals C-term N 365 - S20 E 381 C.S20.05
Hydrophobic H8 G 326 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 G 326 8x47 s5s6 V 78 N.s5s6.07
Polar C-term L 360 - s1s2 R 22 N.s1s2.02
Hydrophobic C-term L 360 - s1s2 R 22 N.s1s2.02
Van-der-waals C-term L 360 - s1s2 R 22 N.s1s2.02
Hydrophobic TM6 A 257 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 257 6x33 s5s6 L 81 N.s5s6.10
Polar H8 V 327 8x48 s5s6 D 77 N.s5s6.06
Polar ICL2 Y 158 34x54 s8s9 P 138 N.s8s9.02
Van-der-waals ICL2 Y 158 34x54 s8s9 P 138 N.s8s9.02
Hydrophobic TM2 S 84 2x37 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 S 84 2x37 s5s6 Q 73 N.s5s6.02
Hydrophobic ICL2 V 155 34x51 S5 Y 71 N.S5.12
Polar TM6 Q 253 6x29 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 Q 253 6x29 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 Q 253 6x29 s9s10 D 166 N.s9s10.08
Polar H8 K 328 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 K 328 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 K 328 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 R 147 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 A 261 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 A 261 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic ICL3 R 251 - S6 R 84 N.S6.02
Van-der-waals ICL3 R 251 - S6 R 84 N.S6.02
Hydrophobic ICL2 V 155 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 V 155 34x51 S15 V 251 C.S15.14
Hydrophobic ICL3 A 248 - S6 R 85 N.S6.03
Hydrophobic C-term A 366 - S20 E 381 C.S20.05
Van-der-waals C-term A 366 - S20 E 381 C.S20.05
Hydrophobic TM6 A 257 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 A 257 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 I 151 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 151 3x54 S6 F 83 N.S6.01
Hydrophobic ICL2 Y 158 34x54 S9 C 147 N.S9.01
Polar TM6 V 258 6x34 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 V 155 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 V 155 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic H8 K 328 8x49 s5s6 V 78 N.s5s6.07
Van-der-waals H8 K 328 8x49 s5s6 V 78 N.s5s6.07
Polar C-term S 361 - s1s2 R 22 N.s1s2.02
Hydrophobic C-term S 361 - s1s2 R 22 N.s1s2.02
Van-der-waals C-term S 361 - s1s2 R 22 N.s1s2.02
Aromatic ICL2 Y 158 34x54 S16 Y 259 C.S16.03
Hydrophobic ICL2 Y 158 34x54 S16 Y 259 C.S16.03
Van-der-waals ICL2 Y 158 34x54 S16 Y 259 C.S16.03
Ionic ICL2 H 156 34x52 S16 D 257 C.S16.01
Polar ICL2 H 156 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 H 156 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 H 156 34x52 S16 D 257 C.S16.01