Beta-arrestin-1 - CXCR6 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
CXCR6 74.9
Beta-arrestin-1 79.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 I 233 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 233 6x37 s5s6 L 71 N.s5s6.08
Polar TM6 S 229 6x33 s5s6 G 72 N.s5s6.09
Polar ICL2 Q 141 34x57 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 Q 141 34x57 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 Q 141 34x57 s5s6 R 65 N.s5s6.02
Polar ICL2 A 134 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 A 134 34x50 S5 Y 63 N.S5.12
Polar TM3 R 127 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 127 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 127 3x50 s5s6 V 70 N.s5s6.07
Polar ICL2 Y 138 34x54 s8s9 G 137 N.s8s9.08
Hydrophobic ICL2 Y 138 34x54 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 Y 138 34x54 s8s9 G 137 N.s8s9.08
Hydrophobic TM3 V 131 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 V 131 3x54 s5s6 L 68 N.s5s6.05
Polar H8 L 293 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic H8 L 293 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 L 293 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 Y 138 34x54 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 Y 138 34x54 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 V 130 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 V 130 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 A 221 5x68 s15s16 F 244 C.s15s16.03
Polar ICL2 A 134 34x50 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 A 134 34x50 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 A 134 34x50 s15s16 F 244 C.s15s16.03
Van-der-waals TM7 Y 288 7x53 s5s6 V 70 N.s5s6.07
Hydrophobic TM2 S 64 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 S 64 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM5 Y 211 5x58 s5s6 L 71 N.s5s6.08
Polar ICL3 G 223 - S6 R 76 N.S6.02
Hydrophobic ICL3 G 223 - S6 R 76 N.S6.02
Van-der-waals ICL3 G 223 - S6 R 76 N.S6.02
Hydrophobic ICL2 Y 138 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 Y 138 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 R 127 3x50 s5s6 L 71 N.s5s6.08
Polar ICL2 Y 138 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 Y 138 34x54 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 Y 138 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL3 F 224 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL3 F 224 - s15s16 F 244 C.s15s16.03
Hydrophobic TM6 I 232 6x36 s5s6 G 72 N.s5s6.09
Ionic H8 K 297 8x52 s20c E 407 C.s20c.17
Polar H8 K 297 8x52 s20c E 407 C.s20c.17
Hydrophobic H8 K 297 8x52 s20c E 407 C.s20c.17
Van-der-waals H8 K 297 8x52 s20c E 407 C.s20c.17
Ionic H8 K 297 8x52 s20c E 404 C.s20c.14
Polar H8 K 297 8x52 s20c E 404 C.s20c.14
Hydrophobic H8 K 297 8x52 s20c E 404 C.s20c.14
Van-der-waals H8 K 297 8x52 s20c E 404 C.s20c.14
Polar ICL2 Y 138 34x54 S16 Y 249 C.S16.03
Aromatic ICL2 Y 138 34x54 S16 Y 249 C.S16.03
Hydrophobic ICL2 Y 138 34x54 S16 Y 249 C.S16.03
Van-der-waals ICL2 Y 138 34x54 S16 Y 249 C.S16.03
Ionic H8 K 294 8x49 s5s6 E 66 N.s5s6.03
Polar H8 K 294 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic H8 K 294 8x49 s5s6 E 66 N.s5s6.03
Van-der-waals H8 K 294 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic TM3 V 131 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 I 214 5x61 s5s6 L 71 N.s5s6.08
Polar ICL3 G 223 - S6 D 78 N.S6.04
Hydrophobic ICL3 G 223 - S6 D 78 N.S6.04
Van-der-waals ICL3 G 223 - S6 D 78 N.S6.04
Hydrophobic TM6 I 232 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 F 224 - s5s6 L 73 N.s5s6.10
Van-der-waals ICL3 F 224 - s5s6 L 73 N.s5s6.10
Polar ICL2 N 139 34x55 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 N 139 34x55 s15s16 T 246 C.s15s16.05
Hydrophobic TM3 V 131 3x54 S6 F 75 N.S6.01
Polar ICL2 Q 141 34x57 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 Q 141 34x57 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 Q 141 34x57 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 V 131 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 V 131 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 Y 138 34x54 S5 Y 63 N.S5.12
Hydrophobic ICL2 N 139 34x55 S16 A 247 C.S16.01
Van-der-waals ICL2 N 139 34x55 S16 A 247 C.S16.01
Polar TM6 S 229 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 S 229 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 S 229 6x33 s5s6 L 71 N.s5s6.08
Polar H8 S 292 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic H8 S 292 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 S 292 8x47 s5s6 D 69 N.s5s6.06
Ionic H8 K 294 8x49 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 T 66 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic H8 S 292 8x47 s5s6 V 70 N.s5s6.07
Polar ICL3 F 224 - S6 R 76 N.S6.02
Hydrophobic ICL3 F 224 - S6 R 76 N.S6.02
Van-der-waals ICL3 F 224 - S6 R 76 N.S6.02
Hydrophobic TM3 V 130 3x53 s5s6 R 65 N.s5s6.02
Polar H8 K 294 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 K 294 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 Y 138 34x54 s8s9 D 135 N.s8s9.06
Ionic H8 K 301 8x56 s20c E 404 C.s20c.14
Polar H8 K 301 8x56 s20c E 404 C.s20c.14
Van-der-waals H8 K 301 8x56 s20c E 404 C.s20c.14
Hydrophobic ICL3 F 224 - s5s6 T 74 N.s5s6.11
Van-der-waals ICL3 F 224 - s5s6 T 74 N.s5s6.11
Polar ICL2 T 135 34x51 s15s16 F 244 C.s15s16.03
Polar ICL2 T 135 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 T 135 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 T 135 34x51 s15s16 N 245 C.s15s16.04
Polar ICL2 T 135 34x51 s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 T 135 34x51 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 T 135 34x51 s15s16 T 246 C.s15s16.05
Aromatic ICL3 F 224 - S6 F 75 N.S6.01
Hydrophobic ICL3 F 224 - S6 F 75 N.S6.01
Van-der-waals ICL3 F 224 - S6 F 75 N.S6.01
Hydrophobic TM6 S 229 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 S 229 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 Y 138 34x54 s8s9 P 131 N.s8s9.02
Van-der-waals ICL2 Y 138 34x54 s8s9 P 131 N.s8s9.02
Hydrophobic TM2 L 70 2x43 s5s6 V 70 N.s5s6.07
Polar ICL2 A 134 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 A 134 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 A 134 34x50 s15s16 N 245 C.s15s16.04
Polar ICL2 N 139 34x55 S16 Y 249 C.S16.03
Hydrophobic TM5 L 218 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 218 5x65 s5s6 L 73 N.s5s6.10