Beta-arrestin-1 - D1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
D1 65.8
Beta-arrestin-1 78.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.4
PAE mean: 22.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 125 3x54 S6 F 75 N.S6.01
Hydrophobic TM5 L 231 5x75 s17s18 I 314 C.s17s18.40
Ionic ICL2 E 132 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 E 132 34x54 s5s6 R 65 N.s5s6.02
Polar TM6 K 269 6x32 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 K 269 6x32 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 K 269 6x32 s5s6 G 72 N.s5s6.09
Hydrophobic TM3 I 125 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 I 125 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 P 128 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 128 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 F 129 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 F 129 34x51 S15 I 241 C.S15.14
Hydrophobic TM5 A 221 5x65 s5s6 L 73 N.s5s6.10
Ionic ICL1 R 52 12x48 s20c D 402 C.s20c.12
Polar ICL1 R 52 12x48 s20c D 402 C.s20c.12
Hydrophobic ICL1 R 52 12x48 s20c D 402 C.s20c.12
Van-der-waals ICL1 R 52 12x48 s20c D 402 C.s20c.12
Polar ICL2 E 132 34x54 s17s18 R 285 C.s17s18.11
Hydrophobic TM5 A 221 5x65 S6 F 75 N.S6.01
Ionic TM2 K 57 2x37 s20c E 404 C.s20c.14
Polar TM2 K 57 2x37 s20c E 404 C.s20c.14
Hydrophobic TM2 K 57 2x37 s20c E 404 C.s20c.14
Van-der-waals TM2 K 57 2x37 s20c E 404 C.s20c.14
Polar TM5 K 239 5x83 S6 V 81 N.S6.07
Van-der-waals TM5 K 239 5x83 S6 V 81 N.S6.07
Hydrophobic TM5 L 231 5x75 S6 K 77 N.S6.03
Van-der-waals TM5 L 231 5x75 S6 K 77 N.S6.03
Hydrophobic TM3 A 124 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 Q 224 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 Q 224 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM3 R 121 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 F 129 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 F 129 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 E 132 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 E 132 34x54 s8s9 D 135 N.s8s9.06
Polar ICL2 Y 131 34x53 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 Y 131 34x53 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 Y 131 34x53 s5s6 R 65 N.s5s6.02
Polar TM5 R 227 5x71 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 R 227 5x71 s15s16 F 244 C.s15s16.03
Ionic H8 K 339 8x52 s20c E 407 C.s20c.17
Polar H8 K 339 8x52 s20c E 407 C.s20c.17
Van-der-waals H8 K 339 8x52 s20c E 407 C.s20c.17
Hydrophobic TM5 Y 214 5x58 s5s6 L 71 N.s5s6.08
Ionic TM5 R 227 5x71 s17s18 E 313 C.s17s18.39
Polar TM5 R 227 5x71 s17s18 E 313 C.s17s18.39
Hydrophobic TM5 R 227 5x71 s17s18 E 313 C.s17s18.39
Van-der-waals TM5 R 227 5x71 s17s18 E 313 C.s17s18.39
Van-der-waals TM2 K 57 2x37 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 E 132 34x54 s8s9 P 131 N.s8s9.02
Polar ICL1 S 56 12x52 s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 S 56 12x52 s8s9 T 136 N.s8s9.07
Hydrophobic TM5 I 228 5x72 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 F 129 34x51 S8 L 129 N.S8.03
Hydrophobic TM6 T 273 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 273 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic C-term A 353 - s9s10 R 161 N.s9s10.13
Van-der-waals C-term A 353 - s9s10 R 161 N.s9s10.13
Ionic ICL1 H 53 12x49 s20c E 404 C.s20c.14
Hydrophobic ICL1 H 53 12x49 s20c E 404 C.s20c.14
Van-der-waals ICL1 H 53 12x49 s20c E 404 C.s20c.14
Hydrophobic TM3 R 121 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 121 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 I 217 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 I 228 5x72 S6 K 77 N.S6.03
Van-der-waals TM5 I 228 5x72 S6 K 77 N.S6.03
Hydrophobic TM6 L 274 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 274 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM7 Y 331 7x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 Y 331 7x53 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 I 217 5x61 s5s6 L 73 N.s5s6.10
Polar TM5 R 227 5x71 S6 K 77 N.S6.03
Hydrophobic TM5 R 227 5x71 S6 K 77 N.S6.03
Van-der-waals TM5 R 227 5x71 S6 K 77 N.S6.03
Hydrophobic TM6 V 270 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 V 270 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 L 231 5x75 S6 L 79 N.S6.05
Hydrophobic TM4 P 137 4x39 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 P 137 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 F 129 34x51 S9 C 140 N.S9.01
Van-der-waals ICL2 F 129 34x51 S9 C 140 N.S9.01
Polar ICL1 R 52 12x48 s20c D 401 C.s20c.11
Hydrophobic TM3 I 125 3x54 s5s6 L 68 N.s5s6.05
Polar TM2 T 59 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 T 59 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 T 59 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM6 I 277 6x40 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 277 6x40 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 F 129 34x51 S16 A 247 C.S16.01
Polar C-term T 354 - s9s10 R 161 N.s9s10.13
Hydrophobic C-term T 354 - s9s10 R 161 N.s9s10.13
Van-der-waals C-term T 354 - s9s10 R 161 N.s9s10.13
Polar TM3 S 126 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 S 126 3x55 s15s16 N 245 C.s15s16.04
Hydrophobic H8 N 334 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 N 334 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 Q 224 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 Q 224 5x68 S6 F 75 N.S6.01
Ionic TM6 K 269 6x32 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 I 125 3x54 s5s6 L 73 N.s5s6.10
Aromatic ICL2 F 129 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 F 129 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 F 129 34x51 S16 Y 249 C.S16.03