S-arrestin - D1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
D1 65.5
S-arrestin 80.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 R 133 34x55 S16 Y 259 C.S16.03
Aromatic ICL2 R 133 34x55 S16 Y 259 C.S16.03
Hydrophobic ICL2 R 133 34x55 S16 Y 259 C.S16.03
Van-der-waals ICL2 R 133 34x55 S16 Y 259 C.S16.03
Ionic TM6 K 265 6x28 s9s10 E 164 N.s9s10.06
Polar TM6 K 265 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic TM5 Y 214 5x58 s5s6 I 79 N.s5s6.08
Polar TM5 A 235 5x79 s7s8 Y 129 N.s7s8.05
Van-der-waals TM5 A 235 5x79 s7s8 Y 129 N.s7s8.05
Hydrophobic ICL2 F 129 34x51 S8 L 136 N.S8.03
Van-der-waals ICL2 F 129 34x51 S8 L 136 N.S8.03
Hydrophobic H8 N 334 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 R 121 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 121 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM5 I 228 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 I 228 5x72 S6 R 85 N.S6.03
Hydrophobic H8 N 334 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic TM5 A 234 5x78 s7s8 Y 129 N.s7s8.05
Hydrophobic TM5 I 217 5x61 s5s6 L 81 N.s5s6.10
Polar TM5 R 227 5x71 S6 R 85 N.S6.03
Hydrophobic TM5 R 227 5x71 S6 R 85 N.S6.03
Van-der-waals TM5 R 227 5x71 S6 R 85 N.S6.03
Polar ICL2 F 129 34x51 S5 Y 71 N.S5.12
Aromatic ICL2 F 129 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 F 129 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 F 129 34x51 S5 Y 71 N.S5.12
Hydrophobic TM6 I 277 6x40 s5s6 I 79 N.s5s6.08
Polar H8 N 334 8x47 s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 F 129 34x51 S9 C 147 N.S9.01
Van-der-waals ICL2 F 129 34x51 S9 C 147 N.S9.01
Ionic ICL2 R 130 34x52 S16 D 257 C.S16.01
Polar ICL2 R 130 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 R 130 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 R 130 34x52 S16 D 257 C.S16.01
Hydrophobic TM5 L 231 5x75 S6 L 87 N.S6.05
Van-der-waals TM5 L 231 5x75 S6 L 87 N.S6.05
Polar TM5 R 227 5x71 s15s16 L 253 C.s15s16.02
Van-der-waals TM5 R 227 5x71 s15s16 L 253 C.s15s16.02
Polar TM5 K 239 5x83 S6 S 90 N.S6.08
Hydrophobic TM5 K 239 5x83 S6 S 90 N.S6.08
Van-der-waals TM5 K 239 5x83 S6 S 90 N.S6.08
Hydrophobic TM5 A 235 5x79 S6 Y 88 N.S6.06
Van-der-waals TM5 A 235 5x79 S6 Y 88 N.S6.06
Ionic TM6 R 266 6x29 S6 D 86 N.S6.04
Polar TM6 R 266 6x29 S6 D 86 N.S6.04
Hydrophobic TM3 I 125 3x54 s5s6 I 76 N.s5s6.05
Polar C-term K 434 - S11 A 197 C.S11.04
Van-der-waals C-term K 434 - S11 A 197 C.S11.04
Polar TM5 R 227 5x71 s15s16 V 252 C.s15s16.01
Hydrophobic TM3 A 124 3x53 s5s6 I 76 N.s5s6.05
Hydrophobic TM3 S 127 3x56 s15s16 S 255 C.s15s16.04
Hydrophobic TM7 Y 331 7x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 331 7x53 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 F 129 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 F 129 34x51 S15 V 251 C.S15.14
Hydrophobic ICL2 F 129 34x51 S16 D 257 C.S16.01
Hydrophobic TM3 I 125 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 125 3x54 S6 F 83 N.S6.01
Hydrophobic TM5 I 217 5x61 s5s6 I 79 N.s5s6.08
Polar ICL2 F 129 34x51 S16 Y 259 C.S16.03
Aromatic ICL2 F 129 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 F 129 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 F 129 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 P 128 34x50 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 P 128 34x50 s15s16 S 255 C.s15s16.04
Polar TM5 Q 224 5x68 S6 R 85 N.S6.03
Polar TM5 R 227 5x71 s17s18 T 323 C.s17s18.39
Hydrophobic TM5 R 227 5x71 s17s18 T 323 C.s17s18.39
Van-der-waals TM5 R 227 5x71 s17s18 T 323 C.s17s18.39
Polar TM6 T 273 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 T 273 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 T 273 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 V 270 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 V 270 6x33 s5s6 L 81 N.s5s6.10
Polar C-term T 354 - s9s10 K 171 N.s9s10.13
Van-der-waals C-term T 354 - s9s10 K 171 N.s9s10.13
Polar TM2 T 59 2x39 s5s6 Q 73 N.s5s6.02
Hydrophobic TM3 I 125 3x54 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 L 274 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 274 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 L 231 5x75 s17s18 V 324 C.s17s18.40
Van-der-waals TM5 L 231 5x75 s17s18 V 324 C.s17s18.40
Hydrophobic TM5 A 221 5x65 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 R 121 3x50 s5s6 I 79 N.s5s6.08
Polar TM5 L 231 5x75 s7s8 Y 129 N.s7s8.05
Hydrophobic TM5 L 231 5x75 s7s8 Y 129 N.s7s8.05
Hydrophobic TM5 L 231 5x75 S6 R 85 N.S6.03
Van-der-waals TM5 L 231 5x75 S6 R 85 N.S6.03
Polar ICL2 E 132 34x54 S5 Y 71 N.S5.12
Hydrophobic ICL2 E 132 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 E 132 34x54 S5 Y 71 N.S5.12
Polar ICL2 E 132 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 E 132 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 E 132 34x54 s8s9 K 145 N.s8s9.09
Polar ICL2 P 128 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 128 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 128 34x50 S5 Y 71 N.S5.12
Hydrophobic TM2 K 57 2x37 s5s6 Q 73 N.s5s6.02
Polar TM5 Q 224 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 Q 224 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 Q 224 5x68 s15s16 Y 254 C.s15s16.03
Ionic TM2 K 57 2x37 s5s6 D 75 N.s5s6.04
Polar TM2 K 57 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic TM2 K 57 2x37 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 K 57 2x37 s5s6 D 75 N.s5s6.04