Arrestin-C - D2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
D2 79.7
Arrestin-C 81.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 16.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic H8 N 430 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 N 430 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 M 140 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 M 140 34x51 S15 V 238 C.S15.14
Hydrophobic ICL2 Y 142 34x53 s5s6 L 64 N.s5s6.05
Van-der-waals ICL2 Y 142 34x53 s5s6 L 64 N.s5s6.05
Polar ICL3 M 358 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 M 358 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 M 358 - s9s10 E 152 N.s9s10.07
Polar ICL2 N 143 34x54 s5s6 R 61 N.s5s6.02
Polar TM4 T 144 4x34 s8s9 D 132 N.s8s9.06
Hydrophobic TM4 T 144 4x34 s8s9 D 132 N.s8s9.06
Van-der-waals TM4 T 144 4x34 s8s9 D 132 N.s8s9.06
Ionic TM5 R 222 5x71 s17s18 E 310 C.s17s18.39
Polar TM5 R 222 5x71 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 R 222 5x71 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 R 222 5x71 s17s18 E 310 C.s17s18.39
Hydrophobic TM6 A 371 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 M 140 34x51 S8 L 126 N.S8.03
Van-der-waals ICL2 M 140 34x51 S8 L 126 N.S8.03
Hydrophobic TM5 L 216 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 L 216 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic ICL3 R 360 - S5 M 52 N.S5.05
Van-der-waals ICL3 R 360 - S5 M 52 N.S5.05
Polar ICL3 K 356 - S6 D 74 N.S6.04
Hydrophobic ICL3 K 356 - S6 D 74 N.S6.04
Van-der-waals ICL3 K 356 - S6 D 74 N.S6.04
Hydrophobic TM6 L 375 6x37 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 V 136 3x54 S6 F 71 N.S6.01
Polar ICL2 M 140 34x51 S5 Y 59 N.S5.12
Hydrophobic ICL2 M 140 34x51 S5 Y 59 N.S5.12
Van-der-waals ICL2 M 140 34x51 S5 Y 59 N.S5.12
Hydrophobic TM3 V 136 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 V 136 3x54 s5s6 L 69 N.s5s6.10
Polar ICL2 M 140 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL2 M 140 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 M 140 34x51 S16 Y 246 C.S16.03
Ionic TM5 K 226 5x75 s17s18 E 310 C.s17s18.39
Polar ICL3 K 356 - S6 L 75 N.S6.05
Hydrophobic ICL3 K 356 - S6 L 75 N.S6.05
Hydrophobic TM6 A 371 6x33 s5s6 G 68 N.s5s6.09
Hydrophobic ICL3 R 360 - S6 V 77 N.S6.07
Hydrophobic ICL3 F 232 - S6 Y 76 N.S6.06
Polar ICL3 S 359 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 S 359 - s9s10 E 152 N.s9s10.07
Polar TM2 T 67 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 T 67 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 T 67 2x37 s5s6 D 63 N.s5s6.04
Ionic ICL3 R 360 - S6 D 74 N.S6.04
Polar ICL3 R 360 - S6 D 74 N.S6.04
Hydrophobic ICL3 R 360 - S6 D 74 N.S6.04
Van-der-waals ICL3 R 360 - S6 D 74 N.S6.04
Polar ICL3 R 360 - S5 T 54 N.S5.07
Hydrophobic ICL3 R 360 - S5 T 54 N.S5.07
Van-der-waals ICL3 R 360 - S5 T 54 N.S5.07
Hydrophobic TM3 A 135 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 A 135 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic ICL3 F 232 - S6 L 75 N.S6.05
Van-der-waals ICL3 F 232 - S6 L 75 N.S6.05
Hydrophobic TM3 M 138 3x56 S16 D 244 C.S16.01
Van-der-waals TM3 M 138 3x56 S16 D 244 C.S16.01
Hydrophobic ICL2 N 143 34x54 s5s6 G 60 N.s5s6.01
Van-der-waals ICL2 N 143 34x54 s5s6 G 60 N.s5s6.01
Hydrophobic TM4 Y 146 4x36 s17s18 R 282 C.s17s18.11
Van-der-waals TM4 Y 146 4x36 s17s18 R 282 C.s17s18.11
Van-der-waals TM7 Y 426 7x53 s5s6 V 66 N.s5s6.07
Polar TM5 R 219 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 R 219 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 R 219 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 R 132 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 132 3x50 s5s6 V 66 N.s5s6.07
Ionic TM5 K 226 5x75 s17s18 D 308 C.s17s18.37
Polar TM5 K 226 5x75 s17s18 D 308 C.s17s18.37
Hydrophobic TM5 K 226 5x75 s17s18 D 308 C.s17s18.37
Van-der-waals TM5 K 226 5x75 s17s18 D 308 C.s17s18.37
Polar TM3 A 137 3x55 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 A 137 3x55 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 A 137 3x55 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 N 143 34x54 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 N 143 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 P 139 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 139 34x50 s15s16 S 242 C.s15s16.04
Polar TM4 R 145 4x35 s8s9 D 132 N.s8s9.06
Hydrophobic TM4 R 145 4x35 s8s9 D 132 N.s8s9.06
Van-der-waals TM4 R 145 4x35 s8s9 D 132 N.s8s9.06
Polar ICL2 P 139 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 P 139 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 139 34x50 S5 Y 59 N.S5.12
Hydrophobic TM5 K 226 5x75 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 K 226 5x75 s17s18 L 311 C.s17s18.40
Hydrophobic ICL3 T 357 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 T 357 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL2 M 140 34x51 S9 C 137 N.S9.01
Van-der-waals ICL2 M 140 34x51 S9 C 137 N.S9.01
Polar ICL2 L 141 34x52 S16 Y 246 C.S16.03
Van-der-waals ICL2 L 141 34x52 S16 Y 246 C.S16.03
Polar TM6 K 367 6x29 s5s6 T 70 N.s5s6.11
Hydrophobic TM6 K 367 6x29 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 K 367 6x29 s5s6 T 70 N.s5s6.11
Hydrophobic TM3 A 135 3x53 S6 F 71 N.S6.01
Van-der-waals TM3 A 135 3x53 S6 F 71 N.S6.01
Hydrophobic TM5 V 223 5x72 S6 K 73 N.S6.03
Van-der-waals TM5 V 223 5x72 S6 K 73 N.S6.03
Ionic TM4 R 145 4x35 s8s9 E 131 N.s8s9.05
Polar TM4 R 145 4x35 s8s9 E 131 N.s8s9.05
Hydrophobic TM4 R 145 4x35 s8s9 E 131 N.s8s9.05
Van-der-waals TM4 R 145 4x35 s8s9 E 131 N.s8s9.05
Hydrophobic TM3 R 132 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 132 3x50 s5s6 I 67 N.s5s6.08
Polar TM6 A 371 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 A 371 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 A 371 6x33 s5s6 I 67 N.s5s6.08
Polar ICL2 P 139 34x50 S16 D 244 C.S16.01
Hydrophobic ICL2 P 139 34x50 S16 D 244 C.S16.01
Van-der-waals ICL2 P 139 34x50 S16 D 244 C.S16.01