S-arrestin - D2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
D2 77.8
S-arrestin 81.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 N 143 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 N 143 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 N 143 34x54 s8s9 K 145 N.s8s9.09
Polar ICL3 S 359 - s9s10 A 163 N.s9s10.05
Hydrophobic ICL3 S 359 - s9s10 A 163 N.s9s10.05
Van-der-waals ICL3 S 359 - s9s10 A 163 N.s9s10.05
Hydrophobic TM3 A 135 3x53 s5s6 I 76 N.s5s6.05
Hydrophobic TM5 V 223 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 V 223 5x72 S6 R 85 N.S6.03
Hydrophobic ICL2 M 140 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 M 140 34x51 S16 Y 259 C.S16.03
Ionic TM5 K 226 5x75 s17s18 D 321 C.s17s18.37
Polar TM5 K 226 5x75 s17s18 D 321 C.s17s18.37
Hydrophobic TM5 K 226 5x75 s17s18 D 321 C.s17s18.37
Van-der-waals TM5 K 226 5x75 s17s18 D 321 C.s17s18.37
Hydrophobic ICL3 K 356 - S6 S 90 N.S6.08
Hydrophobic TM6 A 371 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 A 371 6x33 s5s6 I 79 N.s5s6.08
Polar TM5 K 226 5x75 s17s18 T 323 C.s17s18.39
Van-der-waals TM5 K 226 5x75 s17s18 T 323 C.s17s18.39
Hydrophobic ICL2 M 140 34x51 S9 C 147 N.S9.01
Van-der-waals ICL2 M 140 34x51 S9 C 147 N.S9.01
Hydrophobic TM5 L 216 5x65 s5s6 L 81 N.s5s6.10
Polar TM3 R 132 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 132 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 132 3x50 s5s6 V 78 N.s5s6.07
Polar ICL2 N 143 34x54 S5 Y 71 N.S5.12
Hydrophobic ICL2 N 143 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 N 143 34x54 S5 Y 71 N.S5.12
Polar ICL2 P 139 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 139 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 139 34x50 S5 Y 71 N.S5.12
Hydrophobic TM6 M 374 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 Y 142 34x53 s5s6 I 76 N.s5s6.05
Ionic ICL3 R 360 - S6 D 86 N.S6.04
Polar ICL3 R 360 - S6 D 86 N.S6.04
Hydrophobic ICL3 R 360 - S6 D 86 N.S6.04
Van-der-waals ICL3 R 360 - S6 D 86 N.S6.04
Hydrophobic TM3 R 132 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 132 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic ICL3 K 356 - S6 F 89 N.S6.07
Polar ICL3 R 360 - S5 T 66 N.S5.07
Hydrophobic ICL3 R 360 - S5 T 66 N.S5.07
Van-der-waals ICL3 R 360 - S5 T 66 N.S5.07
Van-der-waals ICL3 F 232 - S6 L 87 N.S6.05
Hydrophobic TM7 Y 426 7x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 426 7x53 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 N 143 34x54 s5s6 G 72 N.s5s6.01
Van-der-waals ICL2 N 143 34x54 s5s6 G 72 N.s5s6.01
Polar TM4 Y 146 4x36 s8s9 D 142 N.s8s9.06
Polar ICL2 M 140 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 M 140 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 M 140 34x51 S5 Y 71 N.S5.12
Polar H8 I 431 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 I 431 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 V 136 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 V 136 3x54 S6 F 83 N.S6.01
Polar TM4 R 145 4x35 s8s9 Q 141 N.s8s9.05
Hydrophobic TM4 R 145 4x35 s8s9 Q 141 N.s8s9.05
Van-der-waals TM4 R 145 4x35 s8s9 Q 141 N.s8s9.05
Hydrophobic ICL2 M 140 34x51 S8 L 136 N.S8.03
Van-der-waals ICL2 M 140 34x51 S8 L 136 N.S8.03
Hydrophobic TM6 L 375 6x37 s5s6 I 79 N.s5s6.08
Ionic ICL1 K 63 12x48 s20c E 395 C.s20c.14
Polar ICL1 K 63 12x48 s20c E 395 C.s20c.14
Van-der-waals ICL1 K 63 12x48 s20c E 395 C.s20c.14
Hydrophobic TM3 A 135 3x53 S6 F 83 N.S6.01
Hydrophobic TM6 A 371 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 371 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic ICL3 F 232 - s7s8 Y 129 N.s7s8.05
Van-der-waals ICL3 F 232 - s7s8 Y 129 N.s7s8.05
Hydrophobic ICL2 P 139 34x50 s15s16 S 255 C.s15s16.04
Polar ICL2 M 140 34x51 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 M 140 34x51 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 M 140 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 M 140 34x51 S15 V 251 C.S15.14
Polar TM4 R 145 4x35 s8s9 D 142 N.s8s9.06
Hydrophobic TM4 R 145 4x35 s8s9 D 142 N.s8s9.06
Van-der-waals TM4 R 145 4x35 s8s9 D 142 N.s8s9.06
Hydrophobic ICL3 F 232 - S6 Y 88 N.S6.06
Polar ICL3 R 360 - S6 Y 88 N.S6.06
Van-der-waals ICL3 R 360 - S6 Y 88 N.S6.06
Polar TM6 K 367 6x29 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 K 367 6x29 s5s6 T 82 N.s5s6.11
Hydrophobic TM2 T 69 2x39 s5s6 V 78 N.s5s6.07
Ionic ICL3 R 360 - s9s10 E 165 N.s9s10.07
Polar ICL3 R 360 - s9s10 E 165 N.s9s10.07
Van-der-waals ICL3 R 360 - s9s10 E 165 N.s9s10.07
Polar ICL3 K 356 - S6 R 91 N.S6.09
Hydrophobic ICL3 K 356 - S6 R 91 N.S6.09
Van-der-waals ICL3 K 356 - S6 R 91 N.S6.09
Hydrophobic H8 N 430 8x47 s5s6 D 77 N.s5s6.06
Polar TM4 T 144 4x34 s8s9 K 145 N.s8s9.09
Hydrophobic TM4 T 144 4x34 s8s9 K 145 N.s8s9.09
Van-der-waals TM4 T 144 4x34 s8s9 K 145 N.s8s9.09
Hydrophobic TM5 K 226 5x75 s17s18 V 324 C.s17s18.40
Van-der-waals TM5 K 226 5x75 s17s18 V 324 C.s17s18.40
Van-der-waals ICL3 R 360 - S6 R 84 N.S6.02
Hydrophobic TM4 T 144 4x34 s8s9 D 142 N.s8s9.06
Van-der-waals TM4 T 144 4x34 s8s9 D 142 N.s8s9.06
Hydrophobic TM2 I 73 2x43 s5s6 V 78 N.s5s6.07
Polar TM5 R 219 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 R 219 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 R 219 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL3 R 360 - S6 F 89 N.S6.07
Van-der-waals ICL3 R 360 - S6 F 89 N.S6.07