Beta-arrestin-1 - D3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
D3 79.6
Beta-arrestin-1 79.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 18.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM2 T 62 2x37 s5s6 R 65 N.s5s6.02
Van-der-waals TM2 T 62 2x37 s5s6 R 65 N.s5s6.02
Hydrophobic TM5 L 215 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 215 5x65 s5s6 L 73 N.s5s6.10
Ionic TM5 R 226 5x76 S6 D 78 N.S6.04
Polar TM5 R 226 5x76 S6 D 78 N.S6.04
Van-der-waals TM5 R 226 5x76 S6 D 78 N.S6.04
Polar ICL2 P 135 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 135 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 135 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL3 L 312 - S6 N 83 N.S6.09
Van-der-waals ICL3 L 312 - S6 N 83 N.S6.09
Hydrophobic TM2 T 64 2x39 s5s6 D 69 N.s5s6.06
Polar H8 N 387 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic H8 N 387 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 N 387 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 A 131 3x53 S6 F 75 N.S6.01
Van-der-waals TM3 A 131 3x53 S6 F 75 N.S6.01
Ionic H8 K 392 8x52 s20c E 405 C.s20c.15
Polar H8 K 392 8x52 s20c E 405 C.s20c.15
Hydrophobic H8 K 392 8x52 s20c E 405 C.s20c.15
Van-der-waals H8 K 392 8x52 s20c E 405 C.s20c.15
Hydrophobic TM3 V 132 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 V 132 3x54 s5s6 L 71 N.s5s6.08
Polar ICL2 Q 139 34x54 s5s6 G 64 N.s5s6.01
Hydrophobic ICL2 Q 139 34x54 s5s6 G 64 N.s5s6.01
Van-der-waals ICL2 Q 139 34x54 s5s6 G 64 N.s5s6.01
Polar TM5 R 222 5x72 S6 R 76 N.S6.02
Van-der-waals TM5 R 222 5x72 S6 R 76 N.S6.02
Hydrophobic ICL2 H 140 34x55 S8 L 129 N.S8.03
Van-der-waals ICL2 H 140 34x55 S8 L 129 N.S8.03
Ionic TM5 R 222 5x72 S6 D 78 N.S6.04
Polar TM5 R 222 5x72 S6 D 78 N.S6.04
Hydrophobic TM5 R 222 5x72 S6 D 78 N.S6.04
Van-der-waals TM5 R 222 5x72 S6 D 78 N.S6.04
Hydrophobic ICL2 Y 138 34x53 s5s6 L 68 N.s5s6.05
Polar ICL2 Q 139 34x54 S5 Y 63 N.S5.12
Hydrophobic ICL2 Q 139 34x54 S5 Y 63 N.S5.12
Van-der-waals ICL2 Q 139 34x54 S5 Y 63 N.S5.12
Polar ICL2 H 140 34x55 S16 Y 249 C.S16.03
Aromatic ICL2 H 140 34x55 S16 Y 249 C.S16.03
Hydrophobic ICL2 H 140 34x55 S16 Y 249 C.S16.03
Van-der-waals ICL2 H 140 34x55 S16 Y 249 C.S16.03
Hydrophobic TM6 R 318 6x24 s9s10 I 158 N.s9s10.10
Polar ICL3 Q 316 - s9s10 E 155 N.s9s10.07
Hydrophobic ICL3 Q 316 - s9s10 E 155 N.s9s10.07
Van-der-waals ICL3 Q 316 - s9s10 E 155 N.s9s10.07
Ionic TM6 R 323 6x29 s5s6 E 66 N.s5s6.03
Polar TM6 R 323 6x29 s5s6 E 66 N.s5s6.03
Hydrophobic TM6 R 323 6x29 s5s6 E 66 N.s5s6.03
Van-der-waals TM6 R 323 6x29 s5s6 E 66 N.s5s6.03
Hydrophobic ICL2 V 136 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 V 136 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals TM6 R 323 6x29 s5s6 G 72 N.s5s6.09
Polar TM6 A 327 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 A 327 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 A 327 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 H 140 34x55 S15 I 241 C.S15.14
Van-der-waals ICL2 H 140 34x55 S15 I 241 C.S15.14
Hydrophobic ICL3 L 315 - s9s10 L 154 N.s9s10.03
Hydrophobic TM3 R 128 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 128 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic H8 E 389 8x49 s5s6 D 67 N.s5s6.04
Polar TM6 R 323 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic TM6 R 323 6x29 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 R 323 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic ICL2 Q 139 34x54 s5s6 L 68 N.s5s6.05
Van-der-waals ICL2 Q 139 34x54 s5s6 L 68 N.s5s6.05
Polar TM6 R 318 6x24 s9s10 L 154 N.s9s10.03
Hydrophobic TM6 R 318 6x24 s9s10 L 154 N.s9s10.03
Van-der-waals TM6 R 318 6x24 s9s10 L 154 N.s9s10.03
Polar ICL2 V 136 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 V 136 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 V 136 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 V 136 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 V 136 34x51 S16 A 247 C.S16.01
Hydrophobic ICL3 L 315 - s9s10 E 155 N.s9s10.07
Polar ICL2 T 142 34x57 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 T 142 34x57 s8s9 D 135 N.s8s9.06
Hydrophobic TM3 V 132 3x54 S6 F 75 N.S6.01
Hydrophobic TM3 V 132 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 V 132 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 R 318 6x24 s9s10 E 155 N.s9s10.07
Van-der-waals TM6 R 318 6x24 s9s10 E 155 N.s9s10.07
Hydrophobic ICL2 V 136 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 V 136 34x51 S15 I 241 C.S15.14
Hydrophobic TM5 I 211 5x61 s5s6 L 71 N.s5s6.08
Polar ICL3 P 317 - s9s10 E 155 N.s9s10.07
Polar ICL1 R 58 12x48 s8s9 P 133 N.s8s9.04
Van-der-waals ICL1 R 58 12x48 s8s9 P 133 N.s8s9.04
Hydrophobic ICL2 V 136 34x51 s15s16 F 244 C.s15s16.03
Polar ICL2 V 136 34x51 S16 Y 249 C.S16.03
Polar ICL2 T 142 34x57 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 T 142 34x57 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 T 142 34x57 s5s6 R 65 N.s5s6.02
Polar ICL2 G 143 34x58 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 V 136 34x51 s15s16 L 243 C.s15s16.02
Hydrophobic TM6 V 331 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 331 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 M 330 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 M 330 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 H 140 34x55 S16 A 247 C.S16.01
Hydrophobic ICL2 P 135 34x50 S6 F 75 N.S6.01
Van-der-waals ICL2 P 135 34x50 S6 F 75 N.S6.01
Hydrophobic ICL1 A 59 12x49 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 P 135 34x50 s15s16 F 244 C.s15s16.03
Polar ICL2 H 137 34x52 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 H 137 34x52 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 H 137 34x52 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 H 137 34x52 s15s16 T 246 C.s15s16.05
Hydrophobic TM5 R 218 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 R 218 5x68 S6 F 75 N.S6.01
Hydrophobic TM2 T 64 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 A 131 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM6 A 327 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 327 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 R 318 6x24 S9 F 149 N.S9.10
Hydrophobic ICL3 L 315 - S6 N 83 N.S6.09
Van-der-waals ICL3 L 315 - S6 N 83 N.S6.09
Hydrophobic TM6 M 330 6x36 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 M 330 6x36 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 128 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 L 312 - s6h1 D 93 N.s6h1.07