S-arrestin - D3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
D3 81.4
S-arrestin 81.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Aromatic ICL2 H 140 34x55 S16 Y 259 C.S16.03
Hydrophobic ICL2 H 140 34x55 S16 Y 259 C.S16.03
Van-der-waals ICL2 H 140 34x55 S16 Y 259 C.S16.03
Polar ICL2 T 142 34x57 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 T 142 34x57 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 T 142 34x57 s8s9 K 145 N.s8s9.09
Polar ICL2 V 136 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 V 136 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 V 136 34x51 S5 Y 71 N.S5.12
Polar TM6 R 323 6x29 s5s6 T 82 N.s5s6.11
Hydrophobic TM6 R 323 6x29 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 R 323 6x29 s5s6 T 82 N.s5s6.11
Hydrophobic TM7 Y 383 7x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 383 7x53 s5s6 V 78 N.s5s6.07
Polar ICL2 T 142 34x57 s8s9 D 142 N.s8s9.06
Hydrophobic TM6 G 319 6x25 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 G 319 6x25 s9s10 E 164 N.s9s10.06
Polar TM5 T 225 5x75 S6 D 86 N.S6.04
Hydrophobic TM5 T 225 5x75 S6 D 86 N.S6.04
Van-der-waals TM5 T 225 5x75 S6 D 86 N.S6.04
Polar ICL2 H 140 34x55 S5 Y 71 N.S5.12
Van-der-waals ICL3 L 315 - s9s10 D 162 N.s9s10.04
Hydrophobic TM5 R 218 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 R 218 5x68 s15s16 Y 254 C.s15s16.03
Polar ICL2 V 136 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 V 136 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 V 136 34x51 S16 Y 259 C.S16.03
Ionic TM5 R 226 5x76 S6 D 86 N.S6.04
Polar TM5 R 226 5x76 S6 D 86 N.S6.04
Hydrophobic TM5 R 226 5x76 S6 D 86 N.S6.04
Van-der-waals TM5 R 226 5x76 S6 D 86 N.S6.04
Hydrophobic TM6 A 327 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 327 6x33 s5s6 L 81 N.s5s6.10
Ionic TM5 R 226 5x76 s9s10 E 165 N.s9s10.07
Polar TM5 R 226 5x76 s9s10 E 165 N.s9s10.07
Hydrophobic TM5 R 226 5x76 s9s10 E 165 N.s9s10.07
Van-der-waals TM5 R 226 5x76 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 R 318 6x24 S6 R 91 N.S6.09
Hydrophobic TM5 L 215 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 215 5x65 s5s6 L 81 N.s5s6.10
Ionic TM5 R 222 5x72 S6 D 86 N.S6.04
Polar TM5 R 222 5x72 S6 D 86 N.S6.04
Hydrophobic TM5 R 222 5x72 S6 D 86 N.S6.04
Van-der-waals TM5 R 222 5x72 S6 D 86 N.S6.04
Hydrophobic TM3 V 132 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 V 132 3x54 S6 F 83 N.S6.01
Hydrophobic ICL2 V 136 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 V 136 34x51 S15 V 251 C.S15.14
Ionic TM6 R 318 6x24 s9s10 E 165 N.s9s10.07
Polar TM6 L 322 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 L 322 6x28 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 L 322 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic ICL3 L 315 - s9s10 T 161 N.s9s10.03
Van-der-waals ICL3 L 315 - s9s10 T 161 N.s9s10.03
Ionic ICL2 H 137 34x52 S16 D 257 C.S16.01
Polar ICL2 H 137 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 H 137 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 H 137 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 P 135 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 P 135 34x50 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 R 318 6x24 S6 F 89 N.S6.07
Van-der-waals TM6 R 318 6x24 S6 F 89 N.S6.07
Polar ICL3 S 229 - S6 F 89 N.S6.07
Hydrophobic ICL3 S 229 - S6 F 89 N.S6.07
Van-der-waals ICL3 S 229 - S6 F 89 N.S6.07
Polar ICL2 V 136 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 V 136 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 Q 139 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 Q 139 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic TM3 R 128 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic ICL3 L 315 - S6 R 91 N.S6.09
Van-der-waals ICL3 L 315 - S6 R 91 N.S6.09
Ionic TM6 R 323 6x29 s5s6 E 74 N.s5s6.03
Polar TM6 R 323 6x29 s5s6 E 74 N.s5s6.03
Hydrophobic TM6 R 323 6x29 s5s6 E 74 N.s5s6.03
Van-der-waals TM6 R 323 6x29 s5s6 E 74 N.s5s6.03
Hydrophobic TM6 P 321 6x27 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 P 321 6x27 s9s10 D 166 N.s9s10.08
Hydrophobic ICL2 H 140 34x55 s17s18 G 296 C.s17s18.12
Van-der-waals ICL2 H 140 34x55 s17s18 G 296 C.s17s18.12
Polar ICL2 P 135 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 135 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 135 34x50 S5 Y 71 N.S5.12
Hydrophobic TM3 R 128 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 128 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic ICL3 Q 230 - S6 F 89 N.S6.07
Hydrophobic TM5 T 225 5x75 S6 Y 88 N.S6.06
Hydrophobic TM3 V 132 3x54 s5s6 I 79 N.s5s6.08
Ionic TM6 K 325 6x31 s9s10 E 164 N.s9s10.06
Polar TM6 K 325 6x31 s9s10 E 164 N.s9s10.06
Hydrophobic ICL3 S 229 - S6 Y 88 N.S6.06
Van-der-waals ICL3 S 229 - S6 Y 88 N.S6.06
Hydrophobic TM3 V 132 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic ICL3 L 312 - S6 R 91 N.S6.09
Van-der-waals ICL3 L 312 - S6 R 91 N.S6.09
Hydrophobic ICL2 P 135 34x50 S6 F 83 N.S6.01
Van-der-waals ICL2 P 135 34x50 S6 F 83 N.S6.01
Hydrophobic TM3 A 131 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 A 131 3x53 S6 F 83 N.S6.01
Hydrophobic TM6 M 330 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 M 330 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 V 136 34x51 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 M 330 6x36 s5s6 V 78 N.s5s6.07
Van-der-waals TM6 M 330 6x36 s5s6 V 78 N.s5s6.07
Hydrophobic TM5 R 218 5x68 S6 F 83 N.S6.01
Van-der-waals TM5 R 218 5x68 S6 F 83 N.S6.01
Polar ICL3 Q 316 - s9s10 D 162 N.s9s10.04
Hydrophobic ICL3 Q 316 - s9s10 D 162 N.s9s10.04
Van-der-waals ICL3 Q 316 - s9s10 D 162 N.s9s10.04
Polar TM6 V 320 6x26 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 V 320 6x26 s9s10 E 164 N.s9s10.06
Ionic TM5 R 222 5x72 s9s10 E 165 N.s9s10.07
Polar TM5 R 222 5x72 s9s10 E 165 N.s9s10.07
Van-der-waals TM5 R 222 5x72 s9s10 E 165 N.s9s10.07
Polar ICL2 Q 139 34x54 S5 Y 71 N.S5.12
Hydrophobic ICL2 Q 139 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 Q 139 34x54 S5 Y 71 N.S5.12
Polar ICL2 H 137 34x52 s15s16 S 255 C.s15s16.04
Hydrophobic TM5 T 225 5x75 S6 L 87 N.S6.05
Van-der-waals TM5 T 225 5x75 S6 L 87 N.S6.05
Polar ICL2 Q 139 34x54 s5s6 G 72 N.s5s6.01
Hydrophobic ICL2 Q 139 34x54 s5s6 G 72 N.s5s6.01
Van-der-waals ICL2 Q 139 34x54 s5s6 G 72 N.s5s6.01
Aromatic TM5 R 226 5x76 S6 F 89 N.S6.07
Hydrophobic TM5 R 226 5x76 S6 F 89 N.S6.07
Hydrophobic TM6 A 327 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 A 327 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 T 64 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 T 64 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 H 140 34x55 S8 L 136 N.S8.03
Van-der-waals ICL2 H 140 34x55 S8 L 136 N.S8.03
Hydrophobic ICL2 V 136 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 V 136 34x51 S16 D 257 C.S16.01
Hydrophobic ICL3 L 312 - S6 V 92 N.S6.10
Polar H8 N 387 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 N 387 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 387 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 A 131 3x53 s5s6 I 76 N.s5s6.05