Arrestin-C - D4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
D4 77.6
Arrestin-C 79.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 19.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 L 230 - S6 L 75 N.S6.05
Van-der-waals ICL3 L 230 - S6 L 75 N.S6.05
Aromatic TM5 W 222 5x68 S6 K 73 N.S6.03
Hydrophobic TM5 W 222 5x68 S6 K 73 N.S6.03
Van-der-waals TM5 W 222 5x68 S6 K 73 N.S6.03
Ionic ICL2 R 145 34x55 S16 D 244 C.S16.01
Polar ICL2 R 145 34x55 S16 D 244 C.S16.01
Hydrophobic ICL2 R 145 34x55 S16 D 244 C.S16.01
Van-der-waals ICL2 R 145 34x55 S16 D 244 C.S16.01
Hydrophobic TM3 A 136 3x53 S6 F 71 N.S6.01
Van-der-waals TM3 A 136 3x53 S6 F 71 N.S6.01
Hydrophobic ICL3 L 230 - s7s8 L 120 N.s7s8.06
Van-der-waals ICL3 L 230 - s7s8 L 120 N.s7s8.06
Hydrophobic TM2 T 69 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 T 69 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 A 344 6x33 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 A 344 6x33 s5s6 G 68 N.s5s6.09
Hydrophobic ICL2 P 140 34x50 s15s16 S 242 C.s15s16.04
Ionic TM5 K 229 5x75 s17s18 E 310 C.s17s18.39
Polar TM5 K 229 5x75 s17s18 E 310 C.s17s18.39
Polar ICL1 R 63 12x48 s5s6 R 61 N.s5s6.02
Hydrophobic TM6 E 341 6x30 S6 K 73 N.S6.03
Van-der-waals TM6 E 341 6x30 S6 K 73 N.S6.03
Hydrophobic TM2 I 73 2x43 s5s6 V 66 N.s5s6.07
Ionic ICL3 R 333 - s6h1 E 86 N.s6h1.03
Polar ICL3 R 333 - s6h1 E 86 N.s6h1.03
Hydrophobic ICL3 R 333 - s6h1 E 86 N.s6h1.03
Van-der-waals ICL3 R 333 - s6h1 E 86 N.s6h1.03
Hydrophobic ICL3 R 330 - s6h1 S 89 N.s6h1.06
Van-der-waals ICL3 R 330 - s6h1 S 89 N.s6h1.06
Hydrophobic ICL2 L 141 34x51 S5 Y 59 N.S5.12
Van-der-waals ICL2 L 141 34x51 S5 Y 59 N.S5.12
Polar TM3 R 133 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 133 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals ICL2 N 144 34x54 s8s9 A 133 N.s8s9.07
Hydrophobic TM2 P 68 2x38 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 L 141 34x51 s15s16 L 240 C.s15s16.02
Polar ICL2 N 144 34x54 S5 Y 59 N.S5.12
Hydrophobic ICL2 N 144 34x54 S5 Y 59 N.S5.12
Van-der-waals ICL2 N 144 34x54 S5 Y 59 N.S5.12
Polar TM5 R 226 5x72 S6 L 75 N.S6.05
Hydrophobic TM5 R 226 5x72 S6 L 75 N.S6.05
Van-der-waals TM5 R 226 5x72 S6 L 75 N.S6.05
Ionic TM6 R 340 6x29 s5s6 E 65 N.s5s6.06
Polar TM6 R 340 6x29 s5s6 E 65 N.s5s6.06
Van-der-waals TM6 R 340 6x29 s5s6 E 65 N.s5s6.06
Hydrophobic TM6 L 348 6x37 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 L 348 6x37 s5s6 I 67 N.s5s6.08
Polar ICL3 R 330 - s6h1 S 88 N.s6h1.05
Hydrophobic ICL3 R 330 - s6h1 S 88 N.s6h1.05
Van-der-waals ICL3 R 330 - s6h1 S 88 N.s6h1.05
Polar ICL2 L 141 34x51 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 L 141 34x51 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 L 141 34x51 s15s16 S 242 C.s15s16.04
Van-der-waals TM6 A 344 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 W 222 5x68 s15s16 L 240 C.s15s16.02
Hydrophobic TM2 I 73 2x43 s5s6 I 67 N.s5s6.08
Van-der-waals TM2 I 73 2x43 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 R 133 3x50 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 R 133 3x50 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 G 147 34x57 s8s9 A 133 N.s8s9.07
Hydrophobic TM6 R 340 6x29 S6 R 72 N.S6.02
Polar ICL2 P 140 34x50 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 P 140 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 P 140 34x50 s15s16 Y 241 C.s15s16.03
Polar ICL3 R 233 - s17s18 P 305 C.s17s18.34
Hydrophobic ICL3 R 233 - s17s18 P 305 C.s17s18.34
Van-der-waals ICL3 R 233 - s17s18 P 305 C.s17s18.34
Polar ICL3 R 333 - S6 T 79 N.S6.09
Van-der-waals ICL3 R 333 - S6 T 79 N.S6.09
Ionic TM6 K 336 6x25 s9s10 E 152 N.s9s10.07
Polar TM6 K 336 6x25 s9s10 E 152 N.s9s10.07
Hydrophobic TM6 K 336 6x25 s9s10 E 152 N.s9s10.07
Van-der-waals TM6 K 336 6x25 s9s10 E 152 N.s9s10.07
Hydrophobic ICL2 L 141 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 L 141 34x51 S15 V 238 C.S15.14
Polar TM6 E 341 6x30 S6 D 74 N.S6.04
Hydrophobic TM3 V 137 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic TM5 K 229 5x75 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 K 229 5x75 s17s18 L 311 C.s17s18.40
Hydrophobic TM3 V 139 3x56 s15s16 S 242 C.s15s16.04
Polar ICL2 N 144 34x54 s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 N 144 34x54 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 N 144 34x54 s8s9 K 135 N.s8s9.09
Polar TM5 R 226 5x72 s17s18 L 311 C.s17s18.40
Hydrophobic TM5 R 226 5x72 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 R 226 5x72 s17s18 L 311 C.s17s18.40
Hydrophobic TM2 T 67 2x37 s5s6 L 64 N.s5s6.05
Van-der-waals TM2 T 67 2x37 s5s6 L 64 N.s5s6.05
Ionic TM5 K 229 5x75 s17s18 D 308 C.s17s18.37
Polar TM5 K 229 5x75 s17s18 D 308 C.s17s18.37
Hydrophobic TM5 K 229 5x75 s17s18 D 308 C.s17s18.37
Van-der-waals TM5 K 229 5x75 s17s18 D 308 C.s17s18.37
Hydrophobic TM5 W 222 5x68 S6 L 75 N.S6.05
Van-der-waals ICL2 R 142 34x52 s15s16 S 242 C.s15s16.04
Hydrophobic TM2 N 70 2x40 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 N 70 2x40 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 V 347 6x36 s5s6 G 68 N.s5s6.09
Hydrophobic ICL3 H 231 - S6 Y 76 N.S6.06
Hydrophobic TM6 E 341 6x30 S6 R 72 N.S6.02
Van-der-waals TM6 E 341 6x30 S6 R 72 N.S6.02
Polar H8 N 404 8x47 s5s6 E 65 N.s5s6.06
Van-der-waals H8 N 404 8x47 s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 L 141 34x51 s15s16 L 243 C.s15s16.05
Hydrophobic ICL1 A 64 12x49 s5s6 D 63 N.s5s6.04
Van-der-waals ICL1 A 64 12x49 s5s6 D 63 N.s5s6.04
Hydrophobic TM6 T 338 6x27 S6 V 77 N.S6.07
Van-der-waals TM6 T 338 6x27 S6 V 77 N.S6.07
Hydrophobic TM6 V 351 6x40 s5s6 I 67 N.s5s6.08
Polar ICL3 L 230 - s7s8 N 119 N.s7s8.05
Hydrophobic ICL3 L 230 - s7s8 N 119 N.s7s8.05
Hydrophobic ICL3 R 330 - s6h1 P 90 N.s6h1.07
Van-der-waals ICL3 R 330 - s6h1 P 90 N.s6h1.07
Polar TM6 T 338 6x27 S6 D 74 N.S6.04
Hydrophobic TM6 T 338 6x27 S6 D 74 N.S6.04
Van-der-waals TM6 T 338 6x27 S6 D 74 N.S6.04
Hydrophobic ICL2 R 145 34x55 s8s9 A 133 N.s8s9.07
Hydrophobic TM3 I 129 3x46 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 I 129 3x46 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 A 344 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic ICL3 L 230 - s17s18 L 311 C.s17s18.40
Polar ICL2 P 140 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 P 140 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 140 34x50 S5 Y 59 N.S5.12
Hydrophobic TM2 T 67 2x37 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 T 67 2x37 s5s6 V 66 N.s5s6.07
Polar ICL2 R 145 34x55 S16 K 245 C.S16.02
Van-der-waals ICL2 R 145 34x55 S16 K 245 C.S16.02
Polar TM3 R 133 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 R 133 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 133 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 V 347 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 V 347 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 L 141 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 L 141 34x51 S16 D 244 C.S16.01
Polar ICL2 R 145 34x55 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 R 145 34x55 s15s16 L 243 C.s15s16.05