ArrestinDb

Beta-arrestin-1 - D₅ receptor complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
D₅	62.6
Beta-arrestin-1	77.9

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.5

iPTM Score: 0.3

PAE mean: 23.7

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Aromatic	ICL2	F	146	34x51	S16	Y	249	C.S16.03
Hydrophobic	ICL2	F	146	34x51	S8	L	129	N.S8.03
Hydrophobic	TM3	R	138	3x50	s5s6	V	70	N.s5s6.07
Hydrophobic	ICL2	F	146	34x51	S16	A	247	C.S16.01
Hydrophobic	TM5	R	258	5x71	S6	K	77	N.S6.03
Hydrophobic	C-term	W	455	-	S15	K	232	C.S15.05
Hydrophobic	ICL2	Y	148	34x53	s5s6	R	65	N.s5s6.02
Hydrophobic	H8	N	362	8x47	s5s6	V	70	N.s5s6.07
Hydrophobic	TM6	T	297	6x36	s5s6	L	71	N.s5s6.08
Hydrophobic	TM6	I	301	6x40	s5s6	L	71	N.s5s6.08
Hydrophobic	C-term	L	457	-	S16	P	252	C.S16.06
Hydrophobic	ICL2	F	146	34x51	S9	C	140	N.S9.01
Hydrophobic	TM5	I	248	5x61	s5s6	L	71	N.s5s6.08
Hydrophobic	TM3	I	142	3x54	s5s6	L	68	N.s5s6.05
Hydrophobic	C-term	C	459	-	S16	C	251	C.S16.05
Hydrophobic	TM5	I	259	5x72	S6	K	77	N.S6.03
Hydrophobic	C-term	G	461	-	S16	Q	248	C.S16.02
Hydrophobic	TM6	L	298	6x37	s5s6	L	71	N.s5s6.08
Hydrophobic	ICL1	A	73	12x52	s8s9	T	136	N.s8s9.07
Hydrophobic	C-term	C	459	-	S16	K	250	C.S16.04
Hydrophobic	C-term	G	461	-	S16	Y	249	C.S16.03
Hydrophobic	TM5	L	262	5x75	s17s18	I	314	C.s17s18.40
Hydrophobic	TM5	A	252	5x65	s5s6	L	73	N.s5s6.10
Hydrophobic	C-term	C	459	-	S16	P	252	C.S16.06
Hydrophobic	TM5	L	262	5x75	S6	L	79	N.S6.05
Hydrophobic	C-term	L	457	-	S16	M	255	C.S16.09
Hydrophobic	ICL1	H	70	12x49	s20c	E	404	C.s20c.14
Hydrophobic	TM5	R	258	5x71	s17s18	E	313	C.s17s18.39
Hydrophobic	TM5	L	262	5x75	S6	K	77	N.S6.03
Hydrophobic	TM5	I	259	5x72	s15s16	F	244	C.s15s16.03
Hydrophobic	TM7	Y	359	7x53	s5s6	V	70	N.s5s6.07
Hydrophobic	ICL2	K	149	34x54	s8s9	P	131	N.s8s9.02
Hydrophobic	TM6	V	294	6x33	s5s6	L	73	N.s5s6.10
Hydrophobic	C-term	V	384	-	s9s10	R	161	N.s9s10.13
Hydrophobic	TM5	Q	255	5x68	S6	F	75	N.S6.01
Hydrophobic	TM3	I	142	3x54	S6	F	75	N.S6.01
Hydrophobic	TM2	N	74	2x37	s5s6	R	65	N.s5s6.02
Hydrophobic	TM4	T	153	4x38	s8s9	E	134	N.s8s9.05
Hydrophobic	ICL2	P	145	34x50	S5	Y	63	N.S5.12
Hydrophobic	TM2	T	76	2x39	s5s6	D	67	N.s5s6.04
Hydrophobic	C-term	I	463	-	S16	A	247	C.S16.01
Hydrophobic	TM5	L	262	5x75	s17s18	E	313	C.s17s18.39
Hydrophobic	TM5	Q	255	5x68	s15s16	F	244	C.s15s16.03
Hydrophobic	ICL2	K	149	34x54	s8s9	D	135	N.s8s9.06
Hydrophobic	ICL2	P	145	34x50	s15s16	N	245	C.s15s16.04
Hydrophobic	TM6	K	293	6x32	s5s6	G	72	N.s5s6.09
Hydrophobic	ICL2	F	146	34x51	S16	Y	249	C.S16.03
Hydrophobic	TM3	I	142	3x54	s5s6	L	71	N.s5s6.08
Hydrophobic	TM5	I	256	5x69	s5s6	L	73	N.s5s6.10
Hydrophobic	ICL2	F	146	34x51	S15	I	241	C.S15.14
Hydrophobic	ICL2	K	149	34x54	s5s6	R	65	N.s5s6.02
Ionic	TM5	R	273	5x86	s7s8	E	118	N.s7s8.01
Ionic	C-term	E	462	-	S16	K	250	C.S16.04
Ionic	ICL1	H	70	12x49	s20c	E	404	C.s20c.14
Ionic	TM5	R	258	5x71	s17s18	E	313	C.s17s18.39
Ionic	ICL1	H	70	12x49	s5s6	E	66	N.s5s6.03
Ionic	ICL2	K	149	34x54	s8s9	D	135	N.s8s9.06
Polar	C-term	E	462	-	S16	Q	248	C.S16.02
Polar	TM2	T	76	2x39	s5s6	R	65	N.s5s6.02
Polar	TM5	R	258	5x71	S6	K	77	N.S6.03
Polar	TM5	R	273	5x86	s7s8	E	118	N.s7s8.01
Polar	ICL2	Y	148	34x53	s5s6	R	65	N.s5s6.02
Polar	TM6	T	297	6x36	s5s6	L	71	N.s5s6.08
Polar	C-term	C	459	-	s17s18	R	285	C.s17s18.11
Polar	ICL2	K	149	34x54	s8s9	G	137	N.s8s9.08
Polar	TM2	N	74	2x37	s8s9	T	136	N.s8s9.07
Polar	C-term	C	459	-	S16	C	251	C.S16.05
Polar	C-term	S	380	-	s9s10	R	161	N.s9s10.13
Polar	ICL1	A	73	12x52	s8s9	T	136	N.s8s9.07
Polar	C-term	C	459	-	S16	K	250	C.S16.04
Polar	C-term	E	462	-	S16	K	250	C.S16.04
Polar	ICL1	H	70	12x49	s20c	E	404	C.s20c.14
Polar	TM5	R	258	5x71	s17s18	E	313	C.s17s18.39
Polar	TM3	S	143	3x55	s15s16	N	245	C.s15s16.04
Polar	ICL1	H	70	12x49	s5s6	E	66	N.s5s6.03
Polar	C-term	T	382	-	s9s10	R	161	N.s9s10.13
Polar	TM3	I	142	3x54	s15s16	N	245	C.s15s16.04
Polar	C-term	Q	398	-	s20c	R	418	C.s20c.28
Polar	C-term	V	384	-	s9s10	R	161	N.s9s10.13
Polar	TM5	Q	270	5x83	S6	V	81	N.S6.07
Polar	TM2	N	74	2x37	s5s6	R	65	N.s5s6.02
Polar	TM5	R	258	5x71	s15s16	F	244	C.s15s16.03
Polar	TM2	T	76	2x39	s5s6	D	67	N.s5s6.04
Polar	TM5	Q	255	5x68	s15s16	F	244	C.s15s16.03
Polar	ICL2	K	149	34x54	s8s9	D	135	N.s8s9.06
Polar	TM3	I	142	3x54	S5	Y	63	N.S5.12
Polar	TM6	K	293	6x32	s5s6	G	72	N.s5s6.09
Polar	C-term	E	460	-	S16	K	250	C.S16.04
Polar	TM2	N	74	2x37	s5s6	D	67	N.s5s6.04
Polar	C-term	S	464	-	s15s16	T	246	C.s15s16.05
Van-der-waals	C-term	E	462	-	S16	Q	248	C.S16.02
Van-der-waals	ICL2	F	146	34x51	S8	L	129	N.S8.03
Van-der-waals	TM3	R	138	3x50	s5s6	V	70	N.s5s6.07
Van-der-waals	TM5	R	258	5x71	S6	K	77	N.S6.03
Van-der-waals	C-term	W	455	-	S15	K	232	C.S15.05
Van-der-waals	ICL2	Y	148	34x53	s5s6	R	65	N.s5s6.02
Van-der-waals	H8	N	362	8x47	s5s6	V	70	N.s5s6.07
Van-der-waals	TM6	T	297	6x36	s5s6	L	71	N.s5s6.08
Van-der-waals	ICL2	K	149	34x54	s8s9	G	137	N.s8s9.08
Van-der-waals	TM6	I	301	6x40	s5s6	L	71	N.s5s6.08
Van-der-waals	TM3	I	142	3x54	s5s6	L	68	N.s5s6.05
Van-der-waals	C-term	C	459	-	S16	C	251	C.S16.05
Van-der-waals	TM5	I	259	5x72	S6	K	77	N.S6.03
Van-der-waals	C-term	G	461	-	S16	Q	248	C.S16.02
Van-der-waals	TM6	L	298	6x37	s5s6	L	71	N.s5s6.08
Van-der-waals	ICL1	A	73	12x52	s8s9	T	136	N.s8s9.07
Van-der-waals	C-term	C	459	-	S16	K	250	C.S16.04
Van-der-waals	TM5	L	262	5x75	s17s18	I	314	C.s17s18.40
Van-der-waals	C-term	E	460	-	S16	Q	248	C.S16.02
Van-der-waals	TM5	A	252	5x65	s5s6	L	73	N.s5s6.10
Van-der-waals	C-term	C	459	-	S16	P	252	C.S16.06
Van-der-waals	C-term	L	457	-	S16	M	255	C.S16.09
Van-der-waals	C-term	E	462	-	S16	K	250	C.S16.04
Van-der-waals	ICL1	H	70	12x49	s20c	E	404	C.s20c.14
Van-der-waals	TM5	R	258	5x71	s17s18	E	313	C.s17s18.39
Van-der-waals	C-term	W	455	-	S16	E	257	C.S16.11
Van-der-waals	TM5	L	262	5x75	S6	K	77	N.S6.03
Van-der-waals	TM3	S	143	3x55	s15s16	N	245	C.s15s16.04
Van-der-waals	ICL2	K	149	34x54	s8s9	P	131	N.s8s9.02
Van-der-waals	C-term	T	382	-	s9s10	R	161	N.s9s10.13
Van-der-waals	C-term	Q	398	-	s20c	R	418	C.s20c.28
Van-der-waals	TM6	V	294	6x33	s5s6	L	73	N.s5s6.10
Van-der-waals	C-term	V	384	-	s9s10	R	161	N.s9s10.13
Van-der-waals	TM5	Q	270	5x83	S6	V	81	N.S6.07
Van-der-waals	TM2	N	74	2x37	s5s6	R	65	N.s5s6.02
Van-der-waals	TM4	T	153	4x38	s8s9	E	134	N.s8s9.05
Van-der-waals	ICL2	P	145	34x50	S5	Y	63	N.S5.12
Van-der-waals	TM5	Q	255	5x68	s15s16	F	244	C.s15s16.03
Van-der-waals	ICL2	K	149	34x54	s8s9	D	135	N.s8s9.06
Van-der-waals	ICL2	P	145	34x50	s15s16	N	245	C.s15s16.04
Van-der-waals	TM3	I	142	3x54	S5	Y	63	N.S5.12
Van-der-waals	TM6	K	293	6x32	s5s6	G	72	N.s5s6.09
Van-der-waals	ICL2	F	146	34x51	S16	Y	249	C.S16.03
Van-der-waals	TM3	I	142	3x54	s5s6	L	71	N.s5s6.08
Van-der-waals	C-term	E	460	-	S16	K	250	C.S16.04
Van-der-waals	ICL2	F	146	34x51	S15	I	241	C.S15.14
Van-der-waals	TM2	N	74	2x37	s5s6	D	67	N.s5s6.04

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Main reference

Beta-arrestin-1 - D5 receptor complex model Download Full