Beta-arrestin-2 - D5 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
D5 62.9
Beta-arrestin-2 77.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.4
PAE mean: 22.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar C-term E 462 - S16 Q 249 C.S16.02
Van-der-waals C-term E 462 - S16 Q 249 C.S16.02
Hydrophobic TM5 Q 255 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 Q 255 5x68 S6 F 76 N.S6.01
Hydrophobic ICL2 F 146 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 F 146 34x51 S15 I 242 C.S15.14
Hydrophobic TM5 L 262 5x75 s15s16 L 244 C.s15s16.02
Hydrophobic TM7 Y 359 7x53 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 L 262 5x75 S6 K 78 N.S6.03
Van-der-waals TM5 L 262 5x75 S6 K 78 N.S6.03
Hydrophobic TM5 A 252 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 A 252 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 I 142 3x54 S6 F 76 N.S6.01
Polar TM2 N 74 2x37 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 T 297 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 T 297 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 I 248 5x61 s5s6 L 74 N.s5s6.10
Ionic ICL1 R 69 12x48 s20c D 402 C.s20c.12
Hydrophobic TM5 L 262 5x75 s17s18 V 315 C.s17s18.40
Van-der-waals TM5 L 262 5x75 s17s18 V 315 C.s17s18.40
Hydrophobic TM3 R 138 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic C-term C 459 - S16 K 251 C.S16.04
Van-der-waals C-term C 459 - S16 K 251 C.S16.04
Polar TM2 T 76 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 Y 245 5x58 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 I 142 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 142 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic C-term G 461 - S16 Q 249 C.S16.02
Van-der-waals C-term G 461 - S16 Q 249 C.S16.02
Hydrophobic C-term I 463 - S16 A 248 C.S16.01
Hydrophobic TM5 L 262 5x75 s17s18 E 314 C.s17s18.39
Polar TM5 Q 270 5x83 S6 I 82 N.S6.07
Hydrophobic TM5 I 248 5x61 s5s6 L 72 N.s5s6.08
Polar C-term V 384 - s9s10 R 162 N.s9s10.13
Hydrophobic C-term V 384 - s9s10 R 162 N.s9s10.13
Van-der-waals C-term V 384 - s9s10 R 162 N.s9s10.13
Polar C-term C 459 - S16 C 252 C.S16.05
Hydrophobic C-term C 459 - S16 C 252 C.S16.05
Van-der-waals C-term C 459 - S16 C 252 C.S16.05
Van-der-waals C-term T 386 - s9s10 R 162 N.s9s10.13
Hydrophobic TM6 L 298 6x37 s5s6 L 72 N.s5s6.08
Ionic C-term E 462 - S16 K 251 C.S16.04
Polar C-term E 462 - S16 K 251 C.S16.04
Van-der-waals C-term E 462 - S16 K 251 C.S16.04
Hydrophobic ICL2 F 146 34x51 S9 C 141 N.S9.01
Hydrophobic ICL1 A 73 12x52 s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 A 73 12x52 s8s9 T 137 N.s8s9.07
Hydrophobic TM6 T 297 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 297 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 K 149 34x54 s5s6 R 66 N.s5s6.02
Polar TM5 R 258 5x71 S6 K 78 N.S6.03
Hydrophobic TM5 R 258 5x71 S6 K 78 N.S6.03
Van-der-waals TM5 R 258 5x71 S6 K 78 N.S6.03
Polar C-term C 459 - s17s18 R 286 C.s17s18.11
Hydrophobic C-term C 459 - s17s18 R 286 C.s17s18.11
Van-der-waals C-term C 459 - s17s18 R 286 C.s17s18.11
Hydrophobic ICL2 P 145 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 145 34x50 S5 Y 64 N.S5.12
Polar TM5 I 259 5x72 S6 K 78 N.S6.03
Hydrophobic TM5 I 259 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 I 259 5x72 S6 K 78 N.S6.03
Polar C-term S 464 - s15s16 T 247 C.s15s16.05
Hydrophobic TM5 L 262 5x75 S6 L 80 N.S6.05
Polar C-term E 460 - S16 K 251 C.S16.04
Hydrophobic C-term E 460 - S16 K 251 C.S16.04
Van-der-waals C-term E 460 - S16 K 251 C.S16.04
Hydrophobic C-term G 461 - S16 Y 250 C.S16.03
Polar C-term E 385 - s9s10 R 162 N.s9s10.13
Hydrophobic C-term E 385 - s9s10 R 162 N.s9s10.13
Van-der-waals C-term E 385 - s9s10 R 162 N.s9s10.13
Ionic ICL2 K 149 34x54 s8s9 D 136 N.s8s9.06
Polar ICL2 K 149 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 K 149 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 K 149 34x54 s8s9 D 136 N.s8s9.06
Polar TM6 K 293 6x32 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 K 293 6x32 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 K 293 6x32 s5s6 G 73 N.s5s6.09
Polar TM5 Q 255 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 Q 255 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 Q 255 5x68 s15s16 F 245 C.s15s16.03
Ionic TM5 R 258 5x71 s17s18 E 314 C.s17s18.39
Polar TM5 R 258 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 R 258 5x71 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 R 258 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic ICL2 F 146 34x51 S16 A 248 C.S16.01
Aromatic ICL2 F 146 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 F 146 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 F 146 34x51 S5 Y 64 N.S5.12
Van-der-waals TM5 Q 270 5x83 S6 F 81 N.S6.06
Polar ICL2 Y 148 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Y 148 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Y 148 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 A 141 3x53 s5s6 L 69 N.s5s6.05
Polar TM5 R 258 5x71 s15s16 L 244 C.s15s16.02
Hydrophobic TM5 R 258 5x71 s15s16 L 244 C.s15s16.02
Van-der-waals TM5 R 258 5x71 s15s16 L 244 C.s15s16.02
Hydrophobic C-term W 455 - S16 E 258 C.S16.11
Van-der-waals C-term W 455 - S16 E 258 C.S16.11
Van-der-waals C-term I 463 - s15s16 T 247 C.s15s16.05
Van-der-waals C-term W 455 - S15 K 233 C.S15.05
Polar TM5 R 258 5x71 s15s16 C 243 C.s15s16.01
Hydrophobic TM6 V 294 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 294 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 R 138 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 138 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 I 142 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 142 3x54 s5s6 L 74 N.s5s6.10
Ionic ICL1 H 70 12x49 s5s6 E 67 N.s5s6.03
Polar ICL1 H 70 12x49 s5s6 E 67 N.s5s6.03
Hydrophobic H8 N 362 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 N 362 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 I 142 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 142 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 I 259 5x72 s15s16 F 245 C.s15s16.03
Hydrophobic C-term L 457 - S16 Q 256 C.S16.09
Van-der-waals C-term L 457 - S16 Q 256 C.S16.09
Polar TM2 N 74 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 N 74 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 N 74 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic ICL1 H 70 12x49 s8s9 T 137 N.s8s9.07
Hydrophobic C-term L 457 - S16 P 253 C.S16.06
Hydrophobic TM6 I 301 6x40 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 I 301 6x40 s5s6 L 72 N.s5s6.08
Hydrophobic C-term T 382 - s9s10 H 160 N.s9s10.11
Aromatic ICL2 F 146 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 F 146 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 F 146 34x51 S16 Y 250 C.S16.03