Beta-arrestin-2 - ETA receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ETA 70.0
Beta-arrestin-2 79.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 22.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 I 196 34x56 s8s9 P 134 N.s8s9.04
Van-der-waals ICL2 I 196 34x56 s8s9 P 134 N.s8s9.04
Hydrophobic ICL2 V 193 34x53 S16 Y 250 C.S16.03
Van-der-waals ICL2 V 193 34x53 S16 Y 250 C.S16.03
Hydrophobic TM2 P 115 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 V 187 3x54 s5s6 L 74 N.s5s6.10
Polar ICL2 W 190 34x50 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 W 190 34x50 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 W 190 34x50 s5s6 R 66 N.s5s6.02
Polar TM6 Q 300 6x29 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 Q 300 6x29 s5s6 G 73 N.s5s6.09
Polar ICL2 Q 194 34x54 s8s9 G 138 N.s8s9.08
Polar H8 K 374 8x48 s20c D 406 C.s20c.16
Hydrophobic ICL2 V 193 34x53 S15 I 242 C.S15.14
Polar ICL1 C 110 12x49 s20c Y 404 C.s20c.14
Hydrophobic ICL1 C 110 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 C 110 12x49 s20c Y 404 C.s20c.14
Polar ICL2 W 190 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 W 190 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 W 190 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 V 193 34x53 s8s9 G 138 N.s8s9.08
Van-der-waals ICL2 V 193 34x53 s8s9 G 138 N.s8s9.08
Hydrophobic TM2 P 115 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 P 115 2x39 s5s6 D 68 N.s5s6.04
Polar ICL2 G 195 34x55 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 G 195 34x55 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 G 195 34x55 s8s9 T 137 N.s8s9.07
Hydrophobic ICL1 C 110 12x49 s5s6 E 67 N.s5s6.03
Van-der-waals ICL1 C 110 12x49 s5s6 E 67 N.s5s6.03
Hydrophobic TM6 V 304 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals H8 N 378 8x52 s20c Q 407 C.s20c.17
Hydrophobic ICL2 I 196 34x56 s8s9 G 133 N.s8s9.03
Van-der-waals ICL2 I 196 34x56 s8s9 G 133 N.s8s9.03
Aromatic TM6 H 297 6x26 S6 F 76 N.S6.01
Hydrophobic TM6 H 297 6x26 S6 F 76 N.S6.01
Van-der-waals TM6 H 297 6x26 S6 F 76 N.S6.01
Hydrophobic TM5 M 282 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 M 282 5x65 s5s6 L 74 N.s5s6.10
Polar ICL2 R 192 34x52 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 R 192 34x52 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 192 34x52 s5s6 R 66 N.s5s6.02
Hydrophobic H8 K 375 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic ICL3 A 293 - S6 I 82 N.S6.07
Polar ICL1 M 111 12x50 s5s6 E 67 N.s5s6.03
Hydrophobic ICL1 M 111 12x50 s5s6 E 67 N.s5s6.03
Hydrophobic ICL3 A 293 - S6 D 79 N.S6.04
Van-der-waals ICL3 A 293 - S6 D 79 N.S6.04
Hydrophobic TM6 Q 300 6x29 s5s6 L 74 N.s5s6.10
Polar ICL2 Q 194 34x54 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 Q 194 34x54 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 Q 194 34x54 s5s6 D 68 N.s5s6.04
Hydrophobic TM6 R 301 6x30 s5s6 L 74 N.s5s6.10
Polar ICL1 N 113 12x52 s5s6 E 67 N.s5s6.03
Hydrophobic ICL1 N 113 12x52 s5s6 E 67 N.s5s6.03
Van-der-waals ICL1 N 113 12x52 s5s6 E 67 N.s5s6.03
Polar H8 K 374 8x48 s20c C 409 C.s20c.19
Van-der-waals H8 K 374 8x48 s20c C 409 C.s20c.19
Hydrophobic ICL2 I 196 34x56 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 I 196 34x56 s8s9 D 136 N.s8s9.06
Hydrophobic TM7 V 372 7x56 s5s6 G 73 N.s5s6.09
Hydrophobic H8 F 376 8x50 s5s6 V 71 N.s5s6.07
Polar ICL2 I 196 34x56 s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 I 196 34x56 s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 I 196 34x56 s8s9 E 135 N.s8s9.05
Hydrophobic TM3 R 183 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 183 3x50 s5s6 L 72 N.s5s6.08
Polar ICL2 S 191 34x51 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 S 191 34x51 s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 S 191 34x51 s15s16 F 245 C.s15s16.03
Hydrophobic TM2 I 119 2x43 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 I 119 2x43 s5s6 V 71 N.s5s6.07
Polar ICL2 R 192 34x52 s15s16 S 246 C.s15s16.04
Hydrophobic TM7 V 372 7x56 s5s6 L 72 N.s5s6.08
Van-der-waals TM7 V 372 7x56 s5s6 L 72 N.s5s6.08
Polar ICL2 I 196 34x56 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 I 196 34x56 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 I 196 34x56 s8s9 T 137 N.s8s9.07
Hydrophobic TM6 V 304 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 304 6x33 s5s6 L 74 N.s5s6.10
Polar H8 S 373 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic H8 S 373 8x47 s5s6 D 70 N.s5s6.06
Van-der-waals H8 S 373 8x47 s5s6 D 70 N.s5s6.06
Polar ICL2 S 191 34x51 s15s16 T 247 C.s15s16.05
Hydrophobic ICL2 S 191 34x51 s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 S 191 34x51 s15s16 T 247 C.s15s16.05
Hydrophobic TM2 N 116 2x40 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 N 116 2x40 s5s6 V 71 N.s5s6.07
Polar TM3 R 183 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 R 183 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 183 3x50 s5s6 V 71 N.s5s6.07
Polar H8 K 374 8x48 s20c Q 407 C.s20c.17
Polar ICL2 Q 194 34x54 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 Q 194 34x54 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 Q 194 34x54 s8s9 T 137 N.s8s9.07
Hydrophobic ICL3 L 290 - S6 L 80 N.S6.05
Hydrophobic TM6 V 308 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 V 193 34x53 S16 A 248 C.S16.01
Van-der-waals ICL2 V 193 34x53 S16 A 248 C.S16.01
Hydrophobic ICL3 L 290 - S6 K 78 N.S6.03
Van-der-waals ICL3 L 290 - S6 K 78 N.S6.03
Hydrophobic TM7 L 369 7x53 s5s6 V 71 N.s5s6.07
Polar TM6 H 297 6x26 S6 R 77 N.S6.02
Hydrophobic TM6 H 297 6x26 S6 R 77 N.S6.02
Van-der-waals TM6 H 297 6x26 S6 R 77 N.S6.02
Polar ICL2 V 193 34x53 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 V 193 34x53 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 V 193 34x53 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 V 187 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 187 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic ICL3 L 290 - S6 D 79 N.S6.04
Van-der-waals ICL3 L 290 - S6 D 79 N.S6.04
Van-der-waals ICL2 V 193 34x53 s5s6 R 66 N.s5s6.02
Polar TM6 Q 300 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 Q 300 6x29 s5s6 S 75 N.s5s6.11
Ionic H8 K 375 8x49 s5s6 E 67 N.s5s6.03
Polar H8 K 375 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 K 375 8x49 s5s6 E 67 N.s5s6.03
Aromatic ICL2 W 190 34x50 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 W 190 34x50 s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 W 190 34x50 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 A 186 3x53 s5s6 D 68 N.s5s6.04
Polar TM6 H 297 6x26 s5s6 S 75 N.s5s6.11
Polar ICL2 S 191 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 S 191 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 S 191 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM6 V 304 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 304 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 M 278 5x61 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 M 278 5x61 s5s6 L 72 N.s5s6.08
Polar TM3 A 186 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 V 193 34x53 s8s9 T 137 N.s8s9.07
Polar TM3 S 189 3x56 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 S 189 3x56 s5s6 R 66 N.s5s6.02