S-arrestin - ETA receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ETA 66.8
S-arrestin 79.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 L 290 - S6 R 85 N.S6.03
Polar ICL2 V 193 34x53 S16 Y 259 C.S16.03
Hydrophobic ICL2 V 193 34x53 S16 Y 259 C.S16.03
Van-der-waals ICL2 V 193 34x53 S16 Y 259 C.S16.03
Ionic TM6 K 299 6x28 s9s10 D 166 N.s9s10.08
Polar TM6 K 299 6x28 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 K 299 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 V 304 6x33 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 V 304 6x33 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 E 296 6x25 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 E 296 6x25 s9s10 E 165 N.s9s10.07
Hydrophobic ICL1 M 111 12x50 s5s6 V 78 N.s5s6.07
Van-der-waals ICL1 M 111 12x50 s5s6 V 78 N.s5s6.07
Van-der-waals ICL2 I 196 34x56 s8s9 K 145 N.s8s9.09
Hydrophobic TM6 V 304 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 V 304 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic ICL1 N 113 12x52 s5s6 I 76 N.s5s6.05
Van-der-waals ICL1 N 113 12x52 s5s6 I 76 N.s5s6.05
Hydrophobic TM3 V 187 3x54 S6 F 83 N.S6.01
Hydrophobic ICL3 A 293 - S6 D 86 N.S6.04
Van-der-waals ICL3 A 293 - S6 D 86 N.S6.04
Hydrophobic ICL3 L 294 - S6 R 85 N.S6.03
Hydrophobic ICL2 V 193 34x53 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 V 193 34x53 s8s9 K 145 N.s8s9.09
Ionic H8 K 375 8x49 s5s6 D 75 N.s5s6.04
Polar H8 K 375 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic H8 K 375 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 K 375 8x49 s5s6 D 75 N.s5s6.04
Polar ICL2 V 193 34x53 s15s16 Y 254 C.s15s16.03
Polar ICL2 V 193 34x53 S16 D 257 C.S16.01
Hydrophobic ICL2 V 193 34x53 S16 D 257 C.S16.01
Van-der-waals ICL2 V 193 34x53 S16 D 257 C.S16.01
Hydrophobic TM5 M 282 5x65 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 G 195 34x55 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 G 195 34x55 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 I 196 34x56 s8s9 A 139 N.s8s9.03
Van-der-waals ICL2 I 196 34x56 s8s9 A 139 N.s8s9.03
Polar ICL2 R 192 34x52 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 R 192 34x52 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 R 192 34x52 s15s16 Y 254 C.s15s16.03
Polar TM6 E 296 6x25 s9s10 D 166 N.s9s10.08
Hydrophobic ICL2 G 195 34x55 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 G 195 34x55 s8s9 K 145 N.s8s9.09
Van-der-waals ICL1 C 110 12x49 s8s9 S 143 N.s8s9.07
Hydrophobic TM6 R 301 6x30 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 R 301 6x30 s5s6 L 81 N.s5s6.10
Polar TM7 V 372 7x56 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 V 304 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 V 304 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 R 192 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 I 196 34x56 s8s9 Q 141 N.s8s9.05
Van-der-waals ICL2 I 196 34x56 s8s9 Q 141 N.s8s9.05
Polar H8 S 373 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic H8 S 373 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 S 373 8x47 s5s6 V 78 N.s5s6.07
Polar ICL2 Q 194 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 Q 194 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 Q 194 34x54 s8s9 K 145 N.s8s9.09
Polar ICL2 S 191 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 S 191 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 S 191 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic H8 K 375 8x49 s5s6 V 78 N.s5s6.07
Van-der-waals H8 K 375 8x49 s5s6 V 78 N.s5s6.07
Hydrophobic TM7 V 372 7x56 s5s6 I 79 N.s5s6.08
Van-der-waals TM7 V 372 7x56 s5s6 I 79 N.s5s6.08
Polar TM6 R 301 6x30 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 R 301 6x30 s15s16 Y 254 C.s15s16.03
Van-der-waals TM6 R 301 6x30 s15s16 Y 254 C.s15s16.03
Aromatic ICL2 W 190 34x50 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 W 190 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 W 190 34x50 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL3 L 290 - S6 D 86 N.S6.04
Polar ICL2 I 196 34x56 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 I 196 34x56 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 I 196 34x56 s8s9 D 142 N.s8s9.06
Polar ICL2 W 190 34x50 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 W 190 34x50 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 W 190 34x50 s15s16 S 255 C.s15s16.04
Polar ICL2 S 191 34x51 s15s16 S 256 C.s15s16.05
Hydrophobic ICL2 S 191 34x51 s15s16 S 256 C.s15s16.05
Van-der-waals ICL2 S 191 34x51 s15s16 S 256 C.s15s16.05
Polar ICL2 R 192 34x52 S5 Y 71 N.S5.12
Hydrophobic ICL2 R 192 34x52 S5 Y 71 N.S5.12
Van-der-waals ICL2 R 192 34x52 S5 Y 71 N.S5.12
Polar ICL2 V 193 34x53 S5 Y 71 N.S5.12
Hydrophobic ICL2 V 193 34x53 S5 Y 71 N.S5.12
Van-der-waals ICL2 V 193 34x53 S5 Y 71 N.S5.12
Polar H8 K 374 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic ICL3 A 293 - S6 F 89 N.S6.07
Hydrophobic TM6 H 297 6x26 S6 F 83 N.S6.01
Van-der-waals TM6 H 297 6x26 S6 F 83 N.S6.01
Polar TM6 H 297 6x26 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 H 297 6x26 s15s16 Y 254 C.s15s16.03
Van-der-waals TM6 H 297 6x26 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL3 I 292 - S6 F 89 N.S6.07
Van-der-waals ICL3 I 292 - S6 F 89 N.S6.07
Polar TM6 H 297 6x26 S6 R 84 N.S6.02
Hydrophobic TM6 H 297 6x26 S6 R 84 N.S6.02
Van-der-waals TM6 H 297 6x26 S6 R 84 N.S6.02
Polar TM6 Q 300 6x29 s5s6 G 80 N.s5s6.09
Polar TM6 Q 300 6x29 s5s6 T 82 N.s5s6.11
Hydrophobic TM6 Q 300 6x29 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 Q 300 6x29 s5s6 T 82 N.s5s6.11
Polar H8 K 375 8x49 s5s6 Q 73 N.s5s6.02
Van-der-waals H8 K 375 8x49 s5s6 Q 73 N.s5s6.02
Hydrophobic ICL2 V 193 34x53 S15 V 251 C.S15.14
Van-der-waals ICL2 V 193 34x53 S15 V 251 C.S15.14
Hydrophobic ICL2 W 190 34x50 S6 R 85 N.S6.03
Van-der-waals ICL2 W 190 34x50 S6 R 85 N.S6.03
Hydrophobic TM3 R 183 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 183 3x50 s5s6 I 79 N.s5s6.08
Polar ICL2 R 192 34x52 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 R 192 34x52 s15s16 S 255 C.s15s16.04
Polar ICL2 Q 194 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 Q 194 34x54 S5 Y 71 N.S5.12
Hydrophobic ICL2 W 190 34x50 s15s16 L 253 C.s15s16.02
Van-der-waals ICL2 W 190 34x50 s15s16 L 253 C.s15s16.02
Polar ICL2 S 191 34x51 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 S 191 34x51 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 S 191 34x51 s15s16 Y 254 C.s15s16.03
Polar ICL2 V 193 34x53 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 V 193 34x53 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 V 193 34x53 s15s16 S 255 C.s15s16.04
Hydrophobic TM7 L 369 7x53 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 I 119 2x43 s5s6 I 79 N.s5s6.08
Hydrophobic ICL3 L 290 - S6 L 87 N.S6.05
Van-der-waals ICL3 L 290 - S6 L 87 N.S6.05
Polar TM6 H 297 6x26 s5s6 T 82 N.s5s6.11
Hydrophobic TM6 H 297 6x26 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 H 297 6x26 s5s6 T 82 N.s5s6.11
Hydrophobic ICL3 A 293 - S6 Y 88 N.S6.06
Hydrophobic TM3 A 186 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 A 186 3x53 S6 F 83 N.S6.01
Polar ICL1 C 110 12x49 s5s6 Q 73 N.s5s6.02
Hydrophobic ICL1 C 110 12x49 s5s6 Q 73 N.s5s6.02
Van-der-waals ICL1 C 110 12x49 s5s6 Q 73 N.s5s6.02
Hydrophobic H8 F 376 8x50 s5s6 V 78 N.s5s6.07
Van-der-waals H8 F 376 8x50 s5s6 V 78 N.s5s6.07