ArrestinDb

Beta-arrestin-1 - ET_B receptor complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
ET_B	71.3
Beta-arrestin-1	81.1

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.7

iPTM Score: 0.6

PAE mean: 16.0

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Aromatic	ICL2	W	206	34x50	S5	Y	63	N.S5.12
Hydrophobic	ICL2	W	206	34x50	s5s6	R	65	N.s5s6.02
Hydrophobic	TM5	M	300	5x65	s5s6	L	73	N.s5s6.10
Hydrophobic	ICL2	K	210	34x54	s5s6	R	65	N.s5s6.02
Hydrophobic	TM2	N	137	2x40	s5s6	V	70	N.s5s6.07
Hydrophobic	ICL2	I	212	34x56	s8s9	D	135	N.s8s9.06
Hydrophobic	TM3	R	199	3x50	s5s6	L	71	N.s5s6.08
Hydrophobic	TM3	V	203	3x54	S6	F	75	N.S6.01
Hydrophobic	TM3	V	203	3x54	s5s6	L	73	N.s5s6.10
Hydrophobic	C-term	L	421	-	s20c	E	404	C.s20c.14
Hydrophobic	ICL2	R	208	34x52	s5s6	R	65	N.s5s6.02
Hydrophobic	ICL2	I	209	34x53	S15	I	241	C.S15.14
Hydrophobic	TM6	Q	317	6x29	s5s6	T	74	N.s5s6.11
Hydrophobic	TM3	A	202	3x53	s5s6	D	67	N.s5s6.04
Hydrophobic	TM2	I	140	2x43	s5s6	V	70	N.s5s6.07
Hydrophobic	ICL2	W	206	34x50	S5	Y	63	N.S5.12
Hydrophobic	H8	K	391	8x48	s20c	E	407	C.s20c.17
Hydrophobic	TM6	K	316	6x28	s9s10	K	157	N.s9s10.09
Hydrophobic	TM5	M	307	5x72	S6	K	77	N.S6.03
Hydrophobic	H8	R	392	8x49	s5s6	E	66	N.s5s6.03
Hydrophobic	TM2	P	136	2x39	s5s6	D	67	N.s5s6.04
Hydrophobic	ICL2	W	206	34x50	S6	F	75	N.S6.01
Hydrophobic	TM5	M	307	5x72	S6	D	78	N.S6.04
Hydrophobic	ICL1	C	131	12x49	s8s9	T	136	N.s8s9.07
Hydrophobic	ICL2	S	207	34x51	S5	Y	63	N.S5.12
Hydrophobic	ICL3	I	309	-	S6	N	83	N.S6.09
Hydrophobic	ICL2	W	206	34x50	S6	R	76	N.S6.02
Hydrophobic	ICL3	A	310	-	S6	D	78	N.S6.04
Hydrophobic	TM3	A	202	3x53	s5s6	R	65	N.s5s6.02
Hydrophobic	TM6	V	325	6x37	s5s6	L	71	N.s5s6.08
Hydrophobic	ICL1	N	134	12x52	s5s6	D	67	N.s5s6.04
Hydrophobic	TM6	H	314	6x26	S6	R	76	N.S6.02
Hydrophobic	ICL2	W	206	34x50	S6	K	77	N.S6.03
Hydrophobic	TM2	P	136	2x39	s5s6	V	70	N.s5s6.07
Hydrophobic	ICL2	K	210	34x54	s5s6	D	67	N.s5s6.04
Hydrophobic	TM6	R	318	6x30	s5s6	L	73	N.s5s6.10
Hydrophobic	ICL2	W	206	34x50	s5s6	L	68	N.s5s6.05
Hydrophobic	TM7	V	389	7x56	s5s6	L	71	N.s5s6.08
Hydrophobic	TM6	Q	317	6x29	s5s6	L	73	N.s5s6.10
Hydrophobic	H8	R	392	8x49	s20c	E	404	C.s20c.14
Hydrophobic	TM3	A	202	3x53	s5s6	L	68	N.s5s6.05
Hydrophobic	ICL2	R	208	34x52	s15s16	F	244	C.s15s16.03
Hydrophobic	TM5	M	296	5x61	s5s6	L	71	N.s5s6.08
Hydrophobic	TM6	V	321	6x33	s5s6	G	72	N.s5s6.09
Hydrophobic	TM3	V	203	3x54	s5s6	L	68	N.s5s6.05
Hydrophobic	ICL3	A	310	-	S6	V	81	N.S6.07
Hydrophobic	H8	R	392	8x49	s5s6	D	69	N.s5s6.06
Hydrophobic	TM3	S	205	3x56	s15s16	F	244	C.s15s16.03
Hydrophobic	TM6	V	321	6x33	s5s6	L	73	N.s5s6.10
Hydrophobic	ICL2	I	209	34x53	S9	C	140	N.S9.01
Hydrophobic	TM3	S	205	3x56	s5s6	R	65	N.s5s6.02
Hydrophobic	ICL2	S	207	34x51	s15s16	F	244	C.s15s16.03
Hydrophobic	TM6	V	321	6x33	s5s6	L	71	N.s5s6.08
Hydrophobic	ICL2	R	208	34x52	s15s16	N	245	C.s15s16.04
Ionic	TM6	D	313	6x25	S9	K	147	N.S9.08
Ionic	H8	K	391	8x48	s20c	E	407	C.s20c.17
Ionic	H8	R	392	8x49	s5s6	E	66	N.s5s6.03
Ionic	ICL2	K	210	34x54	s5s6	D	67	N.s5s6.04
Ionic	TM6	H	314	6x26	S6	D	78	N.S6.04
Ionic	TM6	E	320	6x32	s9s10	K	157	N.s9s10.09
Ionic	H8	R	392	8x49	s20c	E	404	C.s20c.14
Polar	ICL2	W	206	34x50	s5s6	R	65	N.s5s6.02
Polar	ICL2	S	207	34x51	s15s16	N	245	C.s15s16.04
Polar	ICL1	N	134	12x52	s5s6	E	66	N.s5s6.03
Polar	ICL2	R	208	34x52	s5s6	R	65	N.s5s6.02
Polar	TM6	Q	317	6x29	s5s6	T	74	N.s5s6.11
Polar	H8	N	395	8x52	s20c	E	407	C.s20c.17
Polar	TM6	D	313	6x25	S9	K	147	N.S9.08
Polar	TM6	H	314	6x26	s5s6	T	74	N.s5s6.11
Polar	H8	K	391	8x48	s20c	E	407	C.s20c.17
Polar	H8	R	392	8x49	s5s6	E	66	N.s5s6.03
Polar	ICL1	C	131	12x49	s8s9	T	136	N.s8s9.07
Polar	TM6	D	313	6x25	s9s10	I	158	N.s9s10.10
Polar	TM3	A	202	3x53	s5s6	R	65	N.s5s6.02
Polar	TM6	H	314	6x26	S6	R	76	N.S6.02
Polar	H8	S	390	8x47	s5s6	D	69	N.s5s6.06
Polar	TM6	N	312	6x24	s9s10	E	155	N.s9s10.07
Polar	ICL2	K	210	34x54	s5s6	D	67	N.s5s6.04
Polar	TM6	H	314	6x26	S6	D	78	N.S6.04
Polar	TM6	E	320	6x32	s9s10	K	157	N.s9s10.09
Polar	TM3	R	199	3x50	s5s6	V	70	N.s5s6.07
Polar	H8	R	392	8x49	s20c	E	404	C.s20c.14
Polar	TM3	S	205	3x56	s5s6	R	65	N.s5s6.02
Polar	ICL2	R	208	34x52	s15s16	N	245	C.s15s16.04
Polar	ICL2	I	209	34x53	s15s16	N	245	C.s15s16.04
Polar	TM6	Q	317	6x29	s5s6	G	72	N.s5s6.09
Van-der-waals	ICL2	W	206	34x50	s5s6	R	65	N.s5s6.02
Van-der-waals	TM5	M	300	5x65	s5s6	L	73	N.s5s6.10
Van-der-waals	ICL2	S	207	34x51	s15s16	L	243	C.s15s16.02
Van-der-waals	TM2	N	137	2x40	s5s6	V	70	N.s5s6.07
Van-der-waals	ICL2	I	212	34x56	s8s9	D	135	N.s8s9.06
Van-der-waals	TM3	R	199	3x50	s5s6	L	71	N.s5s6.08
Van-der-waals	ICL2	S	207	34x51	s15s16	N	245	C.s15s16.04
Van-der-waals	C-term	L	421	-	s20c	E	404	C.s20c.14
Van-der-waals	ICL2	R	208	34x52	s5s6	R	65	N.s5s6.02
Van-der-waals	ICL2	I	209	34x53	S15	I	241	C.S15.14
Van-der-waals	TM6	Q	317	6x29	s5s6	T	74	N.s5s6.11
Van-der-waals	H8	N	395	8x52	s20c	E	407	C.s20c.17
Van-der-waals	TM6	D	313	6x25	S9	K	147	N.S9.08
Van-der-waals	ICL2	W	206	34x50	S5	Y	63	N.S5.12
Van-der-waals	TM6	H	314	6x26	s5s6	T	74	N.s5s6.11
Van-der-waals	H8	K	391	8x48	s20c	E	407	C.s20c.17
Van-der-waals	TM5	M	307	5x72	S6	K	77	N.S6.03
Van-der-waals	H8	R	392	8x49	s5s6	E	66	N.s5s6.03
Van-der-waals	ICL2	W	206	34x50	S6	F	75	N.S6.01
Van-der-waals	TM5	M	307	5x72	S6	D	78	N.S6.04
Van-der-waals	ICL1	C	131	12x49	s8s9	T	136	N.s8s9.07
Van-der-waals	ICL2	S	207	34x51	S5	Y	63	N.S5.12
Van-der-waals	ICL3	I	309	-	S6	N	83	N.S6.09
Van-der-waals	ICL3	A	310	-	S6	D	78	N.S6.04
Van-der-waals	ICL1	C	131	12x49	s5s6	E	66	N.s5s6.03
Van-der-waals	TM3	A	202	3x53	s5s6	R	65	N.s5s6.02
Van-der-waals	TM6	V	325	6x37	s5s6	L	71	N.s5s6.08
Van-der-waals	TM6	H	314	6x26	S6	R	76	N.S6.02
Van-der-waals	H8	S	390	8x47	s5s6	D	69	N.s5s6.06
Van-der-waals	TM6	N	312	6x24	s9s10	E	155	N.s9s10.07
Van-der-waals	ICL2	K	210	34x54	s5s6	D	67	N.s5s6.04
Van-der-waals	TM3	R	199	3x50	s5s6	V	70	N.s5s6.07
Van-der-waals	H8	R	392	8x49	s20c	E	404	C.s20c.14
Van-der-waals	TM3	A	202	3x53	s5s6	L	68	N.s5s6.05
Van-der-waals	ICL2	R	208	34x52	s15s16	F	244	C.s15s16.03
Van-der-waals	TM5	M	296	5x61	s5s6	L	71	N.s5s6.08
Van-der-waals	H8	R	392	8x49	s5s6	D	69	N.s5s6.06
Van-der-waals	TM6	V	321	6x33	s5s6	L	73	N.s5s6.10
Van-der-waals	ICL2	I	209	34x53	S9	C	140	N.S9.01
Van-der-waals	TM3	S	205	3x56	s5s6	R	65	N.s5s6.02
Van-der-waals	ICL2	S	207	34x51	s15s16	F	244	C.s15s16.03
Van-der-waals	TM6	V	321	6x33	s5s6	L	71	N.s5s6.08
Van-der-waals	ICL2	R	208	34x52	s15s16	N	245	C.s15s16.04
Van-der-waals	ICL2	I	209	34x53	s15s16	N	245	C.s15s16.04
Van-der-waals	TM6	Q	317	6x29	s5s6	G	72	N.s5s6.09

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Main reference

Beta-arrestin-1 - ETB receptor complex model Download Full