S-arrestin - ETB receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
ETB 69.4
S-arrestin 80.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 I 209 34x53 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 I 209 34x53 s15s16 S 255 C.s15s16.04
Polar TM6 N 312 6x24 s9s10 A 163 N.s9s10.05
Van-der-waals TM6 N 312 6x24 s9s10 A 163 N.s9s10.05
Hydrophobic ICL3 A 310 - S6 D 86 N.S6.04
Van-der-waals ICL3 A 310 - S6 D 86 N.S6.04
Hydrophobic TM3 V 203 3x54 s5s6 L 81 N.s5s6.10
Polar TM6 D 313 6x25 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 D 313 6x25 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 D 313 6x25 s9s10 D 166 N.s9s10.08
Hydrophobic ICL3 I 309 - S6 F 89 N.S6.07
Van-der-waals ICL3 I 309 - S6 F 89 N.S6.07
Polar TM6 H 314 6x26 S6 R 84 N.S6.02
Hydrophobic TM6 H 314 6x26 S6 R 84 N.S6.02
Van-der-waals TM6 H 314 6x26 S6 R 84 N.S6.02
Hydrophobic TM3 R 199 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 199 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 G 211 34x55 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 G 211 34x55 s8s9 D 142 N.s8s9.06
Polar H8 K 391 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 K 391 8x48 s5s6 D 77 N.s5s6.06
Polar ICL2 I 212 34x56 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 I 212 34x56 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 I 212 34x56 s8s9 D 142 N.s8s9.06
Hydrophobic TM6 V 321 6x33 s5s6 G 80 N.s5s6.09
Hydrophobic TM5 M 307 5x72 s17s18 V 324 C.s17s18.40
Van-der-waals TM5 M 307 5x72 s17s18 V 324 C.s17s18.40
Hydrophobic TM6 R 318 6x30 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 K 210 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 K 210 34x54 s8s9 K 145 N.s8s9.09
Polar ICL2 I 209 34x53 S5 Y 71 N.S5.12
Hydrophobic ICL2 I 209 34x53 S5 Y 71 N.S5.12
Van-der-waals ICL2 I 209 34x53 S5 Y 71 N.S5.12
Polar TM6 D 313 6x25 s9s10 E 165 N.s9s10.07
Hydrophobic TM6 D 313 6x25 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 D 313 6x25 s9s10 E 165 N.s9s10.07
Polar H8 S 390 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 S 390 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 S 390 8x47 s5s6 D 77 N.s5s6.06
Polar TM6 R 318 6x30 S6 R 84 N.S6.02
Van-der-waals TM6 R 318 6x30 S6 R 84 N.S6.02
Ionic C-term E 415 - s1s2 R 22 N.s1s2.02
Hydrophobic H8 S 390 8x47 s5s6 G 80 N.s5s6.09
Hydrophobic TM5 M 307 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 M 307 5x72 S6 R 85 N.S6.03
Ionic H8 R 392 8x49 s5s6 D 75 N.s5s6.04
Polar H8 R 392 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic H8 R 392 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 R 392 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic TM5 M 300 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 M 300 5x65 s5s6 L 81 N.s5s6.10
Polar TM6 Q 317 6x29 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 Q 317 6x29 s5s6 G 80 N.s5s6.09
Polar ICL2 I 209 34x53 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 I 209 34x53 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 I 209 34x53 s8s9 K 145 N.s8s9.09
Hydrophobic ICL1 C 131 12x49 s5s6 Q 73 N.s5s6.02
Van-der-waals ICL1 C 131 12x49 s5s6 Q 73 N.s5s6.02
Hydrophobic TM5 M 307 5x72 S6 L 87 N.S6.05
Van-der-waals TM5 M 307 5x72 S6 L 87 N.S6.05
Hydrophobic TM5 K 304 5x69 S6 R 85 N.S6.03
Polar ICL2 R 208 34x52 S5 Y 71 N.S5.12
Polar TM6 Q 317 6x29 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 Q 317 6x29 s5s6 T 82 N.s5s6.11
Hydrophobic ICL3 A 310 - S6 Y 88 N.S6.06
Hydrophobic ICL2 G 211 34x55 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 G 211 34x55 s8s9 K 145 N.s8s9.09
Ionic TM6 H 314 6x26 S6 D 86 N.S6.04
Hydrophobic TM6 H 314 6x26 S6 D 86 N.S6.04
Van-der-waals TM6 H 314 6x26 S6 D 86 N.S6.04
Polar ICL2 S 207 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 S 207 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 S 207 34x51 s15s16 S 255 C.s15s16.04
Ionic TM6 K 316 6x28 s9s10 D 166 N.s9s10.08
Polar TM6 K 316 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 K 316 6x28 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 K 316 6x28 s9s10 D 166 N.s9s10.08
Polar C-term Y 430 - s17s18 E 293 C.s17s18.09
Hydrophobic ICL2 I 209 34x53 S15 V 251 C.S15.14
Hydrophobic ICL2 W 206 34x50 S6 R 85 N.S6.03
Van-der-waals ICL2 W 206 34x50 S6 R 85 N.S6.03
Polar TM3 R 199 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 199 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 199 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM7 V 389 7x56 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 P 136 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 P 136 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals ICL2 S 207 34x51 S16 D 257 C.S16.01
Hydrophobic ICL2 W 206 34x50 s15s16 L 253 C.s15s16.02
Van-der-waals ICL2 W 206 34x50 s15s16 L 253 C.s15s16.02
Hydrophobic TM5 M 296 5x61 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 V 321 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic ICL3 A 310 - S5 T 66 N.S5.07
Polar H8 R 392 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 R 392 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 R 392 8x49 s5s6 D 77 N.s5s6.06
Polar ICL3 L 311 - S6 D 86 N.S6.04
Hydrophobic ICL3 L 311 - S6 D 86 N.S6.04
Polar ICL2 I 212 34x56 s8s9 Q 141 N.s8s9.05
Hydrophobic ICL2 I 212 34x56 s8s9 Q 141 N.s8s9.05
Van-der-waals ICL2 I 212 34x56 s8s9 Q 141 N.s8s9.05
Hydrophobic TM3 V 203 3x54 S6 F 83 N.S6.01
Hydrophobic TM6 T 324 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 V 325 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 V 325 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 A 202 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 A 202 3x53 S6 F 83 N.S6.01
Hydrophobic ICL2 I 212 34x56 s8s9 S 143 N.s8s9.07
Van-der-waals ICL2 I 212 34x56 s8s9 S 143 N.s8s9.07
Hydrophobic TM6 V 321 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 V 321 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 I 209 34x53 S16 D 257 C.S16.01
Van-der-waals ICL2 I 209 34x53 S16 D 257 C.S16.01
Hydrophobic ICL2 I 209 34x53 S16 Y 259 C.S16.03
Van-der-waals ICL2 I 209 34x53 S16 Y 259 C.S16.03
Aromatic ICL2 W 206 34x50 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 W 206 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 W 206 34x50 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL3 A 310 - S6 F 89 N.S6.07
Van-der-waals ICL3 A 310 - S6 F 89 N.S6.07
Hydrophobic TM5 M 307 5x72 S6 D 86 N.S6.04
Van-der-waals TM5 M 307 5x72 S6 D 86 N.S6.04
Polar ICL2 S 207 34x51 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 S 207 34x51 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 S 207 34x51 s15s16 Y 254 C.s15s16.03