Beta-arrestin-2 - FFA1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
FFA1 86.6
Beta-arrestin-2 80.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic TM1 R 37 1x64 s8s9 D 136 N.s8s9.06
Polar TM1 R 37 1x64 s8s9 D 136 N.s8s9.06
Hydrophobic TM1 R 37 1x64 s8s9 D 136 N.s8s9.06
Hydrophobic TM2 L 42 2x40 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 L 209 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 209 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals ICL2 R 118 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 A 222 6x34 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 222 6x34 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 A 108 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 A 108 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic ICL3 L 214 - s5s6 L 74 N.s5s6.10
Van-der-waals ICL3 L 214 - s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 L 112 34x51 S9 C 141 N.S9.01
Polar ICL2 G 113 34x52 S16 Y 250 C.S16.03
Hydrophobic ICL3 L 214 - s5s6 S 75 N.s5s6.11
Van-der-waals ICL3 L 214 - s5s6 S 75 N.s5s6.11
Hydrophobic ICL2 Q 115 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Q 115 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 R 211 5x67 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 P 111 34x50 s15s16 S 246 C.s15s16.04
Polar ICL2 L 112 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 112 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 112 34x51 S16 Y 250 C.S16.03
Ionic TM1 R 37 1x64 s5s6 D 68 N.s5s6.04
Polar TM1 R 37 1x64 s5s6 D 68 N.s5s6.04
Hydrophobic TM1 R 37 1x64 s5s6 D 68 N.s5s6.04
Van-der-waals TM1 R 37 1x64 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 R 104 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 104 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 P 111 34x50 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 L 112 34x51 s8s9 A 140 N.s8s9.10
Polar TM3 R 104 3x50 s5s6 D 70 N.s5s6.06
Hydrophobic TM3 R 104 3x50 s5s6 D 70 N.s5s6.06
Van-der-waals TM3 R 104 3x50 s5s6 D 70 N.s5s6.06
Van-der-waals TM2 S 41 2x39 s5s6 L 69 N.s5s6.05
Polar ICL2 P 111 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 111 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 111 34x50 S5 Y 64 N.S5.12
Hydrophobic TM3 G 107 3x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 G 107 3x53 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 L 112 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 112 34x51 S15 I 242 C.S15.14
Ionic ICL2 R 118 34x57 s8s9 D 136 N.s8s9.06
Polar ICL2 R 118 34x57 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 R 118 34x57 s8s9 D 136 N.s8s9.06
Hydrophobic TM6 A 226 6x38 s5s6 L 72 N.s5s6.08
Van-der-waals TM1 R 37 1x64 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 C 205 5x61 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 A 108 3x54 s15s16 F 245 C.s15s16.03
Polar ICL2 L 112 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 112 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 112 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 112 34x51 S8 L 130 N.S8.03
Polar TM3 A 109 3x55 s15s16 S 246 C.s15s16.04
Polar TM1 R 37 1x64 s8s9 E 135 N.s8s9.05
Hydrophobic TM1 R 37 1x64 s8s9 E 135 N.s8s9.05
Van-der-waals TM1 R 37 1x64 s8s9 E 135 N.s8s9.05
Hydrophobic ICL3 G 213 - S6 F 76 N.S6.01
Van-der-waals ICL3 G 213 - S6 F 76 N.S6.01
Ionic ICL2 R 118 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 118 34x57 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 118 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic ICL3 S 212 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 S 212 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 S 212 - S6 F 76 N.S6.01
Hydrophobic TM3 A 108 3x54 s5s6 V 71 N.s5s6.07
Hydrophobic H8 G 280 8x47 s5s6 L 69 N.s5s6.05
Van-der-waals H8 G 280 8x47 s5s6 L 69 N.s5s6.05
Polar TM2 T 39 2x37 s5s6 D 70 N.s5s6.06
Hydrophobic TM2 T 39 2x37 s5s6 D 70 N.s5s6.06
Van-der-waals TM2 T 39 2x37 s5s6 D 70 N.s5s6.06
Polar ICL2 Q 115 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 Q 115 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 Q 115 34x54 s8s9 D 136 N.s8s9.06
Ionic ICL2 R 118 34x57 s5s6 D 70 N.s5s6.06
Polar ICL2 R 118 34x57 s5s6 D 70 N.s5s6.06
Van-der-waals ICL2 R 118 34x57 s5s6 D 70 N.s5s6.06
Ionic TM6 R 218 6x30 s5s6 E 67 N.s5s6.03
Polar TM6 R 218 6x30 s5s6 E 67 N.s5s6.03
Van-der-waals TM6 R 218 6x30 s5s6 E 67 N.s5s6.03
Hydrophobic TM6 V 225 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 225 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 A 222 6x34 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 Q 115 34x54 s8s9 A 140 N.s8s9.10
Van-der-waals ICL2 Q 115 34x54 s8s9 A 140 N.s8s9.10
Hydrophobic TM1 H 33 1x60 s5s6 L 69 N.s5s6.05
Van-der-waals TM1 H 33 1x60 s5s6 L 69 N.s5s6.05
Polar TM1 R 37 1x64 s8s9 T 137 N.s8s9.07
Hydrophobic TM1 R 37 1x64 s8s9 T 137 N.s8s9.07
Van-der-waals TM1 R 37 1x64 s8s9 T 137 N.s8s9.07
Polar TM6 R 218 6x30 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 R 218 6x30 s5s6 G 73 N.s5s6.09
Polar TM2 P 40 2x38 s5s6 D 70 N.s5s6.06
Hydrophobic TM2 P 40 2x38 s5s6 D 70 N.s5s6.06
Van-der-waals TM2 P 40 2x38 s5s6 D 70 N.s5s6.06
Polar TM6 R 218 6x30 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 R 218 6x30 s5s6 S 75 N.s5s6.11
Hydrophobic ICL3 L 214 - S6 F 76 N.S6.01
Polar TM2 S 41 2x39 s5s6 D 70 N.s5s6.06
Hydrophobic TM2 S 41 2x39 s5s6 D 70 N.s5s6.06
Van-der-waals TM2 S 41 2x39 s5s6 D 70 N.s5s6.06