Arrestin-C - FFA1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
FFA1 85.5
Arrestin-C 79.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 18.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 111 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 111 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic TM5 L 209 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 L 209 5x65 s5s6 L 69 N.s5s6.10
Polar H8 T 287 8x54 s20c E 386 C.s20c.20
Hydrophobic H8 T 287 8x54 s20c E 386 C.s20c.20
Van-der-waals H8 T 287 8x54 s20c E 386 C.s20c.20
Hydrophobic ICL3 L 214 - s5s6 T 70 N.s5s6.11
Van-der-waals ICL3 L 214 - s5s6 T 70 N.s5s6.11
Hydrophobic TM2 P 40 2x38 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 P 40 2x38 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 L 112 34x51 S8 L 126 N.S8.03
Polar ICL2 G 113 34x52 S16 Y 246 C.S16.03
Van-der-waals ICL2 G 113 34x52 S16 Y 246 C.S16.03
Hydrophobic H8 P 283 8x50 s20c E 386 C.s20c.20
Van-der-waals H8 P 283 8x50 s20c E 386 C.s20c.20
Polar ICL2 L 112 34x51 S5 Y 59 N.S5.12
Hydrophobic ICL2 L 112 34x51 S5 Y 59 N.S5.12
Van-der-waals ICL2 L 112 34x51 S5 Y 59 N.S5.12
Ionic TM1 R 37 1x64 s5s6 D 62 N.s5s6.03
Polar TM1 R 37 1x64 s5s6 D 62 N.s5s6.03
Hydrophobic TM1 R 37 1x64 s5s6 D 62 N.s5s6.03
Van-der-waals TM1 R 37 1x64 s5s6 D 62 N.s5s6.03
Hydrophobic TM3 G 107 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 G 107 3x53 s5s6 L 64 N.s5s6.05
Polar TM5 R 211 5x67 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 R 211 5x67 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 R 211 5x67 s15s16 Y 241 C.s15s16.03
Ionic ICL2 R 118 34x57 s8s9 D 132 N.s8s9.06
Hydrophobic TM7 L 279 7x56 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 L 279 7x56 s5s6 V 66 N.s5s6.07
Polar ICL3 G 213 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL3 G 213 - s15s16 Y 241 C.s15s16.03
Polar ICL2 L 112 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL2 L 112 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 L 112 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL2 A 116 34x55 S16 Y 246 C.S16.03
Polar ICL3 L 214 - S6 R 72 N.S6.02
Hydrophobic TM3 R 104 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 104 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 V 225 6x37 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 R 104 3x50 s5s6 I 67 N.s5s6.08
Polar ICL3 G 213 - S6 R 72 N.S6.02
Hydrophobic ICL3 G 213 - S6 R 72 N.S6.02
Van-der-waals ICL3 G 213 - S6 R 72 N.S6.02
Hydrophobic ICL3 L 214 - s5s6 L 69 N.s5s6.10
Van-der-waals ICL3 L 214 - s5s6 L 69 N.s5s6.10
Polar ICL2 Q 115 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 Q 115 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 Q 115 34x54 s5s6 R 61 N.s5s6.02
Polar ICL2 G 113 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 G 113 34x52 S16 D 244 C.S16.01
Van-der-waals ICL2 G 113 34x52 S16 D 244 C.S16.01
Hydrophobic ICL3 L 214 - S6 F 71 N.S6.01
Polar ICL2 L 112 34x51 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 L 112 34x51 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 L 112 34x51 s5s6 R 61 N.s5s6.02
Hydrophobic ICL3 G 213 - S6 K 73 N.S6.03
Hydrophobic TM6 A 222 6x34 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 A 222 6x34 s5s6 I 67 N.s5s6.08
Polar TM1 R 37 1x64 s8s9 A 133 N.s8s9.07
Hydrophobic TM1 R 37 1x64 s8s9 A 133 N.s8s9.07
Van-der-waals TM1 R 37 1x64 s8s9 A 133 N.s8s9.07
Hydrophobic TM2 T 39 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 T 39 2x37 s5s6 D 63 N.s5s6.04
Polar ICL2 P 111 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 P 111 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 111 34x50 S5 Y 59 N.S5.12
Polar H8 G 284 8x51 s20c E 386 C.s20c.20
Hydrophobic H8 G 284 8x51 s20c E 386 C.s20c.20
Van-der-waals H8 G 284 8x51 s20c E 386 C.s20c.20
Hydrophobic TM3 A 108 3x54 S6 F 71 N.S6.01
Polar ICL2 L 112 34x51 S16 D 244 C.S16.01
Hydrophobic ICL2 L 112 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 L 112 34x51 S16 D 244 C.S16.01
Polar TM1 R 37 1x64 s8s9 E 131 N.s8s9.05
Hydrophobic TM1 R 37 1x64 s8s9 E 131 N.s8s9.05
Van-der-waals TM1 R 37 1x64 s8s9 E 131 N.s8s9.05
Hydrophobic ICL3 S 212 - S6 F 71 N.S6.01
Van-der-waals ICL3 S 212 - S6 F 71 N.S6.01
Hydrophobic ICL3 S 212 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL3 S 212 - s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 A 108 3x54 s5s6 L 64 N.s5s6.05
Ionic TM1 H 33 1x60 s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 L 112 34x51 S9 C 137 N.S9.01
Polar TM6 R 218 6x30 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 R 218 6x30 s5s6 T 70 N.s5s6.11
Polar ICL2 P 111 34x50 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 P 111 34x50 s5s6 R 61 N.s5s6.02
Ionic TM1 R 37 1x64 s8s9 D 132 N.s8s9.06
Polar TM1 R 37 1x64 s8s9 D 132 N.s8s9.06
Hydrophobic TM1 R 37 1x64 s8s9 D 132 N.s8s9.06
Van-der-waals TM1 R 37 1x64 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 R 118 34x57 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 F 110 3x56 s15s16 S 242 C.s15s16.04
Hydrophobic TM2 S 41 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 S 41 2x39 s5s6 V 66 N.s5s6.07
Ionic ICL2 R 118 34x57 s5s6 D 63 N.s5s6.04
Polar ICL2 R 118 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 R 118 34x57 s5s6 D 63 N.s5s6.04
Van-der-waals ICL2 R 118 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 L 112 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 L 112 34x51 S15 V 238 C.S15.14
Polar ICL2 Q 115 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 Q 115 34x54 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 Q 115 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic TM6 A 222 6x34 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 A 222 6x34 s5s6 L 69 N.s5s6.10