Beta-arrestin-2 - FFA2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
FFA2 81.3
Beta-arrestin-2 78.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL1 P 41 - s8s9 E 135 N.s8s9.05
Hydrophobic ICL1 P 41 - s8s9 E 135 N.s8s9.05
Van-der-waals ICL1 P 41 - s8s9 E 135 N.s8s9.05
Hydrophobic ICL3 L 211 - S6 K 78 N.S6.03
Van-der-waals ICL3 L 211 - S6 K 78 N.S6.03
Hydrophobic ICL2 K 118 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 L 223 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 223 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 A 224 6x38 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 L 48 2x43 s5s6 L 69 N.s5s6.05
Van-der-waals TM2 L 48 2x43 s5s6 L 69 N.s5s6.05
Polar ICL2 V 115 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 V 115 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 V 115 34x51 S5 Y 64 N.S5.12
Hydrophobic TM5 M 206 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 M 206 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 V 115 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 V 115 34x51 S16 A 248 C.S16.01
Ionic TM2 H 45 2x40 s5s6 D 68 N.s5s6.04
Polar TM2 H 45 2x40 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 H 45 2x40 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 H 45 2x40 s5s6 D 68 N.s5s6.04
Polar TM6 R 216 6x30 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 R 216 6x30 s5s6 S 75 N.s5s6.11
Hydrophobic TM2 V 44 2x39 s5s6 L 69 N.s5s6.05
Hydrophobic ICL3 L 211 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 L 211 - s15s16 F 245 C.s15s16.03
Ionic TM1 R 35 1x60 s5s6 D 68 N.s5s6.04
Polar TM1 R 35 1x60 s5s6 D 68 N.s5s6.04
Hydrophobic TM1 R 35 1x60 s5s6 D 68 N.s5s6.04
Van-der-waals TM1 R 35 1x60 s5s6 D 68 N.s5s6.04
Polar ICL3 L 211 - S6 R 77 N.S6.02
Van-der-waals ICL3 L 211 - S6 R 77 N.S6.02
Hydrophobic TM5 F 202 5x61 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 F 202 5x61 s5s6 L 72 N.s5s6.08
Polar H8 R 286 8x56 s20c Y 404 C.s20c.14
Hydrophobic ICL2 L 119 34x55 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 119 34x55 S16 Y 250 C.S16.03
Hydrophobic ICL1 Q 40 - s8s9 E 135 N.s8s9.05
Van-der-waals ICL1 Q 40 - s8s9 E 135 N.s8s9.05
Polar ICL1 Q 40 - s17s18 R 286 C.s17s18.11
Hydrophobic ICL1 Q 40 - s17s18 R 286 C.s17s18.11
Van-der-waals ICL1 Q 40 - s17s18 R 286 C.s17s18.11
Hydrophobic TM3 V 111 3x54 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 V 111 3x54 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 A 220 6x34 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 220 6x34 s5s6 L 74 N.s5s6.10
Ionic ICL2 K 118 34x54 s8s9 D 136 N.s8s9.06
Polar ICL2 K 118 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 K 118 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 K 118 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 R 121 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 121 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Q 116 34x52 S16 A 248 C.S16.01
Van-der-waals ICL2 Q 116 34x52 S16 A 248 C.S16.01
Hydrophobic ICL3 V 212 - s5s6 L 74 N.s5s6.10
Polar TM2 A 42 2x37 s8s9 E 135 N.s8s9.05
Hydrophobic TM5 F 202 5x61 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 F 202 5x61 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 V 115 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 V 115 34x51 S15 I 242 C.S15.14
Ionic ICL2 R 121 34x57 s5s6 D 70 N.s5s6.06
Polar ICL2 R 121 34x57 s5s6 D 70 N.s5s6.06
Van-der-waals ICL2 R 121 34x57 s5s6 D 70 N.s5s6.06
Hydrophobic TM2 H 45 2x40 s5s6 L 69 N.s5s6.05
Van-der-waals TM2 H 45 2x40 s5s6 L 69 N.s5s6.05
Hydrophobic ICL3 V 212 - S6 F 76 N.S6.01
Van-der-waals ICL3 V 212 - S6 F 76 N.S6.01
Hydrophobic ICL2 V 115 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM2 V 44 2x39 s5s6 D 70 N.s5s6.06
Van-der-waals TM2 V 44 2x39 s5s6 D 70 N.s5s6.06
Polar TM1 R 35 1x60 s8s9 E 135 N.s8s9.05
Hydrophobic TM1 F 32 1x57 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 R 107 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 A 220 6x34 s5s6 L 72 N.s5s6.08
Hydrophobic H8 S 277 8x47 s5s6 L 69 N.s5s6.05
Van-der-waals H8 S 277 8x47 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 P 114 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 P 114 34x50 s15s16 S 246 C.s15s16.04
Polar H8 R 282 8x52 s20c Y 404 C.s20c.14
Aromatic H8 R 282 8x52 s20c Y 404 C.s20c.14
Van-der-waals H8 R 282 8x52 s20c Y 404 C.s20c.14
Ionic TM2 H 45 2x40 s5s6 D 70 N.s5s6.06
Polar ICL2 V 115 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 V 115 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 V 115 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 119 34x55 s17s18 R 286 C.s17s18.11
Hydrophobic TM5 M 206 5x65 S6 F 76 N.S6.01
Hydrophobic TM3 V 111 3x54 s5s6 L 74 N.s5s6.10
Polar TM1 R 35 1x60 s8s9 T 137 N.s8s9.07
Hydrophobic TM1 R 35 1x60 s8s9 T 137 N.s8s9.07
Van-der-waals TM1 R 35 1x60 s8s9 T 137 N.s8s9.07
Hydrophobic H8 V 279 8x49 s5s6 L 69 N.s5s6.05
Polar ICL2 P 114 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 114 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 114 34x50 S5 Y 64 N.S5.12
Polar H8 S 278 8x48 s5s6 E 67 N.s5s6.03
Polar ICL2 Q 116 34x52 s15s16 T 247 C.s15s16.05
Hydrophobic TM4 P 123 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM3 G 110 3x53 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 Q 209 5x68 S6 F 76 N.S6.01
Polar TM5 Q 209 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 Q 209 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 Q 209 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM7 S 276 7x56 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 A 42 2x37 s5s6 D 70 N.s5s6.06
Van-der-waals TM2 A 42 2x37 s5s6 D 70 N.s5s6.06
Hydrophobic TM3 V 111 3x54 S6 F 76 N.S6.01
Ionic ICL2 R 121 34x57 s8s9 D 136 N.s8s9.06
Polar ICL2 R 121 34x57 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 R 121 34x57 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 L 119 34x55 s17s18 G 287 C.s17s18.12