Beta-arrestin-2 - FFA3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
FFA3 78.2
Beta-arrestin-2 76.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 121 34x51 S8 L 130 N.S8.03
Hydrophobic TM6 V 223 6x34 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 223 6x34 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 L 207 5x61 s5s6 L 74 N.s5s6.10
Ionic TM1 R 46 1x64 s5s6 D 68 N.s5s6.04
Polar TM1 R 46 1x64 s5s6 D 68 N.s5s6.04
Hydrophobic TM1 R 46 1x64 s5s6 D 68 N.s5s6.04
Van-der-waals TM1 R 46 1x64 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 I 210 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 V 223 6x34 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 223 6x34 s5s6 L 74 N.s5s6.10
Polar H8 F 283 8x50 s5s6 D 70 N.s5s6.06
Van-der-waals TM3 A 118 3x55 s15s16 F 245 C.s15s16.03
Polar ICL2 L 121 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 121 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 121 34x51 S5 Y 64 N.S5.12
Polar H8 S 280 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic H8 S 280 8x47 s5s6 D 70 N.s5s6.06
Van-der-waals H8 S 280 8x47 s5s6 D 70 N.s5s6.06
Polar ICL2 P 120 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 120 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 120 34x50 S5 Y 64 N.S5.12
Polar H8 G 282 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic H8 G 282 8x49 s5s6 D 70 N.s5s6.06
Van-der-waals H8 G 282 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic TM2 V 50 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 V 50 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 V 117 3x54 s5s6 L 74 N.s5s6.10
Polar TM6 R 219 6x30 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 R 219 6x30 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 R 219 6x30 s5s6 S 75 N.s5s6.11
Polar H8 S 281 8x48 s5s6 D 70 N.s5s6.06
Van-der-waals H8 S 281 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 L 121 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 121 34x51 S15 I 242 C.S15.14
Polar TM3 A 118 3x55 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 A 118 3x55 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 A 118 3x55 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 V 117 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 V 117 3x54 S6 F 76 N.S6.01
Hydrophobic ICL2 K 124 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 T 125 34x55 S16 Y 250 C.S16.03
Van-der-waals ICL2 T 125 34x55 S16 Y 250 C.S16.03
Hydrophobic ICL2 Y 123 34x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 H 119 3x56 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 H 119 3x56 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 L 121 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL3 G 214 - s15s16 F 245 C.s15s16.03
Hydrophobic TM6 L 226 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 226 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 S 116 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 S 116 3x53 s5s6 L 69 N.s5s6.05
Polar ICL2 L 121 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 121 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 121 34x51 S16 Y 250 C.S16.03
Polar H8 S 280 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 L 211 5x65 S6 F 76 N.S6.01
Van-der-waals TM5 L 211 5x65 S6 F 76 N.S6.01
Hydrophobic ICL2 K 124 34x54 S5 Y 64 N.S5.12
Van-der-waals ICL2 K 124 34x54 S5 Y 64 N.S5.12
Hydrophobic TM5 L 211 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 211 5x65 s5s6 L 74 N.s5s6.10
Polar TM1 R 46 1x64 s20c Y 404 C.s20c.14
Aromatic TM1 R 46 1x64 s20c Y 404 C.s20c.14
Hydrophobic TM1 R 46 1x64 s20c Y 404 C.s20c.14
Van-der-waals TM1 R 46 1x64 s20c Y 404 C.s20c.14
Hydrophobic TM6 R 219 6x30 S6 R 77 N.S6.02
Van-der-waals TM6 R 219 6x30 S6 R 77 N.S6.02
Hydrophobic ICL2 L 121 34x51 S9 C 141 N.S9.01
Hydrophobic TM7 S 279 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 S 279 7x56 s5s6 V 71 N.s5s6.07
Polar TM3 R 113 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 R 113 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 113 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 I 210 5x64 S6 F 76 N.S6.01
Van-der-waals TM5 I 210 5x64 S6 F 76 N.S6.01
Hydrophobic TM6 R 222 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 V 48 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 L 121 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 121 34x51 S16 A 248 C.S16.01
Polar ICL2 K 124 34x54 s8s9 A 140 N.s8s9.10
Van-der-waals ICL2 K 124 34x54 s8s9 A 140 N.s8s9.10
Hydrophobic TM6 R 219 6x30 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 R 219 6x30 s5s6 L 74 N.s5s6.10
Polar ICL2 P 120 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 P 120 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 P 120 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic TM5 L 207 5x61 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 L 207 5x61 s5s6 L 72 N.s5s6.08
Ionic TM1 K 42 1x60 s5s6 D 70 N.s5s6.06
Polar TM1 K 42 1x60 s5s6 D 70 N.s5s6.06
Van-der-waals TM1 K 42 1x60 s5s6 D 70 N.s5s6.06
Polar TM1 R 46 1x64 s8s9 T 137 N.s8s9.07
Hydrophobic TM1 R 46 1x64 s8s9 T 137 N.s8s9.07
Van-der-waals TM1 R 46 1x64 s8s9 T 137 N.s8s9.07
Ionic ICL2 K 124 34x54 s8s9 D 136 N.s8s9.06
Polar ICL2 K 124 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 K 124 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 K 124 34x54 s8s9 D 136 N.s8s9.06