Arrestin-C - FFA4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
FFA4 76.0
Arrestin-C 78.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 245 5x76 s7s8 L 120 N.s7s8.06
Hydrophobic TM7 Y 321 7x53 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 Y 321 7x53 s5s6 V 66 N.s5s6.07
Polar TM7 T 324 7x56 s5s6 G 68 N.s5s6.09
Hydrophobic TM7 T 324 7x56 s5s6 G 68 N.s5s6.09
Van-der-waals TM7 T 324 7x56 s5s6 G 68 N.s5s6.09
Polar ICL2 R 145 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 R 145 34x52 S16 D 244 C.S16.01
Van-der-waals ICL2 R 145 34x52 S16 D 244 C.S16.01
Polar ICL2 L 143 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 L 143 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 L 143 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic TM5 L 245 5x76 S6 L 75 N.S6.05
Van-der-waals TM5 L 245 5x76 S6 L 75 N.S6.05
Hydrophobic ICL2 L 143 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 L 143 34x50 S5 Y 59 N.S5.12
Hydrophobic TM3 I 140 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 I 140 3x54 S6 F 71 N.S6.01
Hydrophobic TM5 T 234 5x65 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 L 241 5x72 S6 K 73 N.S6.03
Van-der-waals TM5 L 241 5x72 S6 K 73 N.S6.03
Hydrophobic TM5 L 241 5x72 S6 L 75 N.S6.05
Van-der-waals TM5 L 241 5x72 S6 L 75 N.S6.05
Polar TM6 H 251 6x23 S6 D 74 N.S6.04
Hydrophobic TM6 H 251 6x23 S6 D 74 N.S6.04
Van-der-waals TM6 H 251 6x23 S6 D 74 N.S6.04
Hydrophobic TM3 R 136 3x50 s5s6 L 64 N.s5s6.05
Hydrophobic TM5 L 241 5x72 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 L 241 5x72 s17s18 L 311 C.s17s18.40
Hydrophobic ICL2 R 148 34x55 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 R 148 34x55 s8s9 A 133 N.s8s9.07
Hydrophobic TM5 L 245 5x76 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 L 245 5x76 s17s18 L 311 C.s17s18.40
Polar C-term A 344 - s20c S 388 C.s20c.22
Hydrophobic C-term A 344 - s20c S 388 C.s20c.22
Van-der-waals C-term A 344 - s20c S 388 C.s20c.22
Hydrophobic C-term K 342 - s20c S 388 C.s20c.22
Van-der-waals C-term K 342 - s20c S 388 C.s20c.22
Hydrophobic TM6 L 269 6x41 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 G 146 34x53 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 G 146 34x53 s8s9 A 133 N.s8s9.07
Polar H8 N 328 8x50 s9s10 K 157 N.s9s10.12
Hydrophobic H8 N 328 8x50 s9s10 K 157 N.s9s10.12
Van-der-waals H8 N 328 8x50 s9s10 K 157 N.s9s10.12
Hydrophobic TM3 R 136 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 136 3x50 s5s6 I 67 N.s5s6.08
Polar TM6 Q 258 6x30 S6 D 74 N.S6.04
Van-der-waals TM6 Q 258 6x30 S6 D 74 N.S6.04
Hydrophobic TM6 R 254 6x26 S6 V 77 N.S6.07
Van-der-waals TM6 R 254 6x26 S6 V 77 N.S6.07
Hydrophobic TM1 R 68 1x60 s5s6 V 66 N.s5s6.07
Van-der-waals TM1 R 68 1x60 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 R 254 6x26 S5 M 52 N.S5.05
Hydrophobic ICL2 V 147 34x54 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 V 147 34x54 s8s9 A 133 N.s8s9.07
Hydrophobic TM5 S 244 5x75 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 S 244 5x75 s17s18 L 311 C.s17s18.40
Polar ICL2 Q 144 34x51 S16 D 244 C.S16.01
Hydrophobic ICL2 Q 144 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 Q 144 34x51 S16 D 244 C.S16.01
Polar ICL2 L 143 34x50 s15s16 L 243 C.s15s16.05
Hydrophobic TM5 L 241 5x72 s15s16 L 240 C.s15s16.02
Van-der-waals TM5 L 241 5x72 s15s16 L 240 C.s15s16.02
Hydrophobic C-term E 341 - s20c S 388 C.s20c.22
Van-der-waals C-term E 341 - s20c S 388 C.s20c.22
Polar TM3 C 139 3x53 s8s9 K 135 N.s8s9.09
Hydrophobic TM3 C 139 3x53 s8s9 K 135 N.s8s9.09
Van-der-waals TM3 C 139 3x53 s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 Q 144 34x51 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 Q 144 34x51 s15s16 S 242 C.s15s16.04
Polar TM5 S 237 5x68 S6 K 73 N.S6.03
Van-der-waals TM5 S 237 5x68 S6 K 73 N.S6.03
Polar C-term G 343 - s20c S 388 C.s20c.22
Hydrophobic C-term G 343 - s20c S 388 C.s20c.22
Van-der-waals C-term G 343 - s20c S 388 C.s20c.22
Polar ICL1 T 74 - s5s6 D 63 N.s5s6.04
Hydrophobic ICL1 T 74 - s5s6 D 63 N.s5s6.04
Polar ICL2 Q 144 34x51 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 Q 144 34x51 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 Q 144 34x51 s15s16 Y 241 C.s15s16.03
Polar TM5 S 237 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 S 237 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 S 237 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 L 143 34x50 S16 D 244 C.S16.01
Van-der-waals ICL2 L 143 34x50 S16 D 244 C.S16.01
Hydrophobic TM6 L 266 6x38 s5s6 L 69 N.s5s6.10
Hydrophobic H8 L 325 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 L 325 8x47 s5s6 V 66 N.s5s6.07
Polar TM5 S 244 5x75 s17s18 D 308 C.s17s18.37
Hydrophobic TM5 S 244 5x75 s17s18 D 308 C.s17s18.37
Van-der-waals TM5 S 244 5x75 s17s18 D 308 C.s17s18.37
Hydrophobic ICL3 Y 247 - S6 Y 76 N.S6.06
Polar TM7 T 324 7x56 s5s6 E 65 N.s5s6.06
Van-der-waals TM7 T 324 7x56 s5s6 E 65 N.s5s6.06
Polar ICL2 Q 144 34x51 s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 Q 144 34x51 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 Q 144 34x51 s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 L 143 34x50 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 L 143 34x50 s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 R 148 34x55 s8s9 D 132 N.s8s9.06
Ionic TM5 R 240 5x71 s17s18 E 310 C.s17s18.39
Polar TM5 R 240 5x71 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 R 240 5x71 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 R 240 5x71 s17s18 E 310 C.s17s18.39
Ionic TM6 R 254 6x26 S6 D 74 N.S6.04
Polar TM6 R 254 6x26 S6 D 74 N.S6.04
Polar ICL2 G 146 34x53 S16 D 244 C.S16.01
Hydrophobic ICL2 G 146 34x53 S16 D 244 C.S16.01
Van-der-waals ICL2 G 146 34x53 S16 D 244 C.S16.01
Hydrophobic TM5 R 238 5x69 S6 K 73 N.S6.03
Van-der-waals TM5 R 238 5x69 S6 K 73 N.S6.03
Hydrophobic TM6 H 251 6x23 S6 V 77 N.S6.07
Van-der-waals TM6 H 251 6x23 S6 V 77 N.S6.07
Hydrophobic TM6 L 262 6x34 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 L 262 6x34 s5s6 L 69 N.s5s6.10
Polar TM7 T 324 7x56 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 T 324 7x56 s5s6 V 66 N.s5s6.07
Polar ICL3 Y 247 - S6 D 74 N.S6.04
Van-der-waals ICL3 Y 247 - S6 D 74 N.S6.04
Polar TM7 T 324 7x56 s5s6 I 67 N.s5s6.08
Hydrophobic TM7 T 324 7x56 s5s6 I 67 N.s5s6.08
Van-der-waals TM7 T 324 7x56 s5s6 I 67 N.s5s6.08
Polar TM6 H 251 6x23 S6 Y 76 N.S6.06
Hydrophobic TM6 H 251 6x23 S6 Y 76 N.S6.06
Hydrophobic C-term I 359 - H1 K 104 N.H1.09
Van-der-waals C-term I 359 - H1 K 104 N.H1.09
Polar TM1 R 68 1x60 s5s6 D 62 N.s5s6.03
Van-der-waals TM1 R 68 1x60 s5s6 D 62 N.s5s6.03
Ionic ICL2 R 148 34x55 s8s9 E 131 N.s8s9.05
Polar ICL2 R 148 34x55 s8s9 E 131 N.s8s9.05
Hydrophobic ICL2 R 148 34x55 s8s9 E 131 N.s8s9.05
Van-der-waals ICL2 R 148 34x55 s8s9 E 131 N.s8s9.05
Polar ICL3 Y 247 - S6 L 75 N.S6.05
Hydrophobic ICL3 Y 247 - S6 L 75 N.S6.05
Van-der-waals ICL3 Y 247 - S6 L 75 N.S6.05