Arrestin-C - FPR2/ALX complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
FPR2/ALX 85.6
Arrestin-C 81.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 15.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 M 233 - S6 F 71 N.S6.01
Van-der-waals ICL3 M 233 - S6 F 71 N.S6.01
Hydrophobic TM7 Y 302 7x53 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 Y 302 7x53 s5s6 V 66 N.s5s6.07
Polar ICL2 P 130 34x50 S16 D 244 C.S16.01
Hydrophobic TM6 P 239 6x33 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 P 239 6x33 s5s6 G 68 N.s5s6.09
Polar TM4 S 140 4x40 s8s9 E 131 N.s8s9.05
Hydrophobic ICL2 V 131 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 V 131 34x51 S16 Y 246 C.S16.03
Polar ICL2 Q 134 34x54 s17s18 R 282 C.s17s18.11
Van-der-waals ICL2 Q 134 34x54 s17s18 R 282 C.s17s18.11
Hydrophobic TM3 C 126 3x53 s5s6 L 64 N.s5s6.05
Ionic H8 R 312 8x53 s20c E 383 C.s20c.17
Polar H8 R 312 8x53 s20c E 383 C.s20c.17
Van-der-waals H8 R 312 8x53 s20c E 383 C.s20c.17
Polar ICL2 V 131 34x51 S16 D 244 C.S16.01
Hydrophobic ICL2 V 131 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 V 131 34x51 S16 D 244 C.S16.01
Hydrophobic TM5 I 228 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 I 228 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic TM5 K 231 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 K 231 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 I 224 5x61 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 P 130 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 130 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic H8 G 306 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic TM2 Y 64 2x43 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 R 123 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 123 3x50 s5s6 I 67 N.s5s6.08
Polar ICL2 Q 134 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic TM3 V 127 3x54 S6 F 71 N.S6.01
Hydrophobic TM3 V 127 3x54 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 V 127 3x54 s5s6 L 64 N.s5s6.05
Hydrophobic TM2 T 58 2x37 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 V 131 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 V 131 34x51 S15 V 238 C.S15.14
Van-der-waals TM7 V 305 7x56 s5s6 V 66 N.s5s6.07
Ionic ICL3 K 235 - S6 D 74 N.S6.04
Polar ICL3 K 235 - S6 D 74 N.S6.04
Van-der-waals ICL3 K 235 - S6 D 74 N.S6.04
Polar ICL2 N 135 34x55 S16 K 248 C.S16.05
Hydrophobic ICL2 N 135 34x55 S16 K 248 C.S16.05
Hydrophobic ICL3 M 233 - s5s6 T 70 N.s5s6.11
Polar ICL2 P 130 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 P 130 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 130 34x50 S5 Y 59 N.S5.12
Polar ICL2 Q 134 34x54 s8s9 Q 127 N.s8s9.01
Hydrophobic TM6 P 239 6x33 s5s6 L 69 N.s5s6.10
Polar TM6 P 239 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 P 239 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 P 239 6x33 s5s6 I 67 N.s5s6.08
Polar ICL2 Q 134 34x54 S8 L 126 N.S8.03
Hydrophobic TM6 R 238 6x32 s5s6 G 68 N.s5s6.09
Polar TM4 V 139 4x39 s8s9 E 131 N.s8s9.05
Hydrophobic TM4 V 139 4x39 s8s9 E 131 N.s8s9.05
Van-der-waals TM4 V 139 4x39 s8s9 E 131 N.s8s9.05
Polar ICL2 R 137 34x57 s17s18 R 282 C.s17s18.11
Van-der-waals ICL2 R 137 34x57 s17s18 R 282 C.s17s18.11
Hydrophobic TM4 T 138 4x38 s17s18 R 282 C.s17s18.11
Van-der-waals TM4 T 138 4x38 s17s18 R 282 C.s17s18.11
Polar TM2 T 60 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 T 60 2x39 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 T 60 2x39 s5s6 D 63 N.s5s6.04
Polar ICL2 R 137 34x57 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 R 137 34x57 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 R 137 34x57 s5s6 R 61 N.s5s6.02
Polar TM5 K 227 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 K 227 5x64 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 K 227 5x64 s15s16 Y 241 C.s15s16.03
Ionic TM3 H 129 3x56 S16 D 244 C.S16.01
Ionic ICL2 R 137 34x57 s5s6 D 63 N.s5s6.04
Polar ICL2 R 137 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 R 137 34x57 s5s6 D 63 N.s5s6.04
Van-der-waals ICL2 R 137 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic ICL1 T 56 - s8s9 A 133 N.s8s9.07
Polar ICL2 A 133 34x53 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 A 133 34x53 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 A 133 34x53 s5s6 R 61 N.s5s6.02
Hydrophobic TM6 V 242 6x36 s5s6 I 67 N.s5s6.08
Polar ICL2 Q 134 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 Q 134 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 Q 134 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic ICL3 M 233 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL3 M 233 - s15s16 Y 241 C.s15s16.03
Polar TM3 C 126 3x53 S5 Y 59 N.S5.12