Beta-arrestin-2 - FSH receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
FSH 80.5
Beta-arrestin-2 76.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 17.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 L 477 34x53 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 477 34x53 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 477 34x53 S16 Y 250 C.S16.03
Ionic ICL1 K 393 - s8s9 E 135 N.s8s9.05
Polar ICL1 K 393 - s8s9 E 135 N.s8s9.05
Hydrophobic ICL1 K 393 - s8s9 E 135 N.s8s9.05
Van-der-waals ICL1 K 393 - s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 M 475 34x51 S9 C 141 N.S9.01
Hydrophobic TM5 V 556 5x65 S5 Y 64 N.S5.12
Hydrophobic TM3 R 467 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 467 3x50 s5s6 V 71 N.s5s6.07
Polar ICL3 N 558 - S6 D 79 N.S6.04
Van-der-waals ICL3 N 558 - S6 D 79 N.S6.04
Hydrophobic ICL2 Q 476 34x52 S16 A 248 C.S16.01
Van-der-waals ICL2 Q 476 34x52 S16 A 248 C.S16.01
Hydrophobic C-term S 660 - s20c K 400 C.s20c.10
Van-der-waals C-term S 660 - s20c K 400 C.s20c.10
Hydrophobic ICL2 M 475 34x51 S5 F 62 N.S5.10
Van-der-waals ICL2 M 475 34x51 S5 F 62 N.S5.10
Polar ICL2 Q 476 34x52 s15s16 T 247 C.s15s16.05
Polar TM6 R 573 6x36 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 R 573 6x36 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 R 573 6x36 s5s6 G 73 N.s5s6.09
Hydrophobic C-term Y 684 - S16 K 251 C.S16.04
Van-der-waals C-term Y 684 - S16 K 251 C.S16.04
Hydrophobic C-term Y 654 - s20c Y 404 C.s20c.14
Van-der-waals C-term Y 654 - s20c Y 404 C.s20c.14
Ionic ICL2 K 480 34x56 s8s9 D 136 N.s8s9.06
Polar ICL2 K 480 34x56 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 K 480 34x56 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 K 480 34x56 s8s9 D 136 N.s8s9.06
Hydrophobic C-term V 687 - S16 K 251 C.S16.04
Van-der-waals C-term V 687 - S16 K 251 C.S16.04
Hydrophobic TM3 I 471 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 I 471 3x54 S6 F 76 N.S6.01
Polar TM5 T 555 5x64 S5 Y 64 N.S5.12
Van-der-waals TM5 T 555 5x64 S5 Y 64 N.S5.12
Polar H8 N 632 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic ICL2 M 475 34x51 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 S 563 6x26 S6 I 82 N.S6.07
Van-der-waals TM6 S 563 6x26 S6 I 82 N.S6.07
Van-der-waals ICL2 M 475 34x51 s15s16 S 246 C.s15s16.04
Polar C-term T 658 - s20c K 400 C.s20c.10
Hydrophobic C-term T 658 - s20c K 400 C.s20c.10
Van-der-waals C-term T 658 - s20c K 400 C.s20c.10
Hydrophobic ICL2 K 480 34x56 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 K 480 34x56 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 L 577 6x40 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 577 6x40 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 E 466 3x49 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 M 574 6x37 S6 F 76 N.S6.01
Van-der-waals TM6 M 574 6x37 S6 F 76 N.S6.01
Hydrophobic C-term Y 684 - S16 P 253 C.S16.06
Polar TM3 T 470 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 T 470 3x53 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 T 470 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 M 576 6x39 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 I 471 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 R 467 3x50 s5s6 L 69 N.s5s6.05
Polar C-term S 660 - s20c D 401 C.s20c.11
Hydrophobic ICL3 N 558 - S6 K 78 N.S6.03
Hydrophobic ICL3 I 561 - S6 I 82 N.S6.07
Hydrophobic TM6 L 577 6x40 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 L 577 6x40 s5s6 V 71 N.s5s6.07
Van-der-waals H8 T 630 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic TM5 V 556 5x65 S6 R 77 N.S6.02
Van-der-waals TM5 V 556 5x65 S6 R 77 N.S6.02
Hydrophobic TM2 P 397 2x39 s5s6 D 68 N.s5s6.04
Polar TM7 L 625 7x52 s5s6 L 72 N.s5s6.08
Hydrophobic TM7 L 625 7x52 s5s6 L 72 N.s5s6.08
Van-der-waals TM7 L 625 7x52 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 I 471 3x54 S5 Y 64 N.S5.12
Van-der-waals TM3 I 471 3x54 S5 Y 64 N.S5.12
Polar TM6 R 573 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 R 573 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 R 573 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 I 561 - S6 L 80 N.S6.05
Van-der-waals ICL3 I 561 - S6 L 80 N.S6.05
Polar ICL2 M 475 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 M 475 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 M 475 34x51 S16 Y 250 C.S16.03
Polar C-term Y 684 - S16 C 252 C.S16.05
Hydrophobic C-term Y 684 - S16 C 252 C.S16.05
Van-der-waals C-term Y 684 - S16 C 252 C.S16.05
Hydrophobic TM7 F 629 7x56 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 M 475 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 M 475 34x51 S15 I 242 C.S15.14
Polar ICL2 Q 476 34x52 S16 Y 250 C.S16.03
Hydrophobic ICL2 Q 476 34x52 S16 Y 250 C.S16.03
Van-der-waals ICL2 Q 476 34x52 S16 Y 250 C.S16.03
Polar C-term S 660 - s20c M 399 C.s20c.09
Polar TM6 S 566 6x29 S6 D 79 N.S6.04
Hydrophobic TM6 R 573 6x36 s5s6 L 74 N.s5s6.10
Polar C-term T 661 - s20c K 400 C.s20c.10
Hydrophobic C-term T 661 - s20c K 400 C.s20c.10
Van-der-waals C-term T 661 - s20c K 400 C.s20c.10
Hydrophobic TM6 I 570 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 I 570 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 I 552 5x61 S6 F 76 N.S6.01
Van-der-waals TM5 I 552 5x61 S6 F 76 N.S6.01
Hydrophobic ICL2 A 474 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 A 474 34x50 S5 Y 64 N.S5.12
Hydrophobic C-term E 657 - s20c D 401 C.s20c.11
Van-der-waals C-term E 657 - s20c D 401 C.s20c.11
Hydrophobic ICL2 L 477 34x53 s17s18 G 287 C.s17s18.12
Van-der-waals ICL2 L 477 34x53 s17s18 G 287 C.s17s18.12
Hydrophobic TM6 M 574 6x37 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 M 475 34x51 s15s16 L 244 C.s15s16.02
Hydrophobic TM3 T 470 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 T 470 3x53 s5s6 L 69 N.s5s6.05
Polar TM6 S 563 6x26 S6 D 79 N.S6.04
Hydrophobic TM6 S 563 6x26 S6 D 79 N.S6.04
Van-der-waals TM6 S 563 6x26 S6 D 79 N.S6.04
Polar ICL2 Q 476 34x52 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 Q 476 34x52 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 M 475 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 M 475 34x51 S16 A 248 C.S16.01
Hydrophobic TM5 V 556 5x65 S6 F 76 N.S6.01
Hydrophobic ICL3 I 561 - S6 F 81 N.S6.06
Van-der-waals ICL3 I 561 - S6 F 81 N.S6.06
Hydrophobic TM7 Y 626 7x53 s5s6 V 71 N.s5s6.07
Hydrophobic ICL3 I 561 - S6 D 79 N.S6.04
Van-der-waals ICL3 I 561 - S6 D 79 N.S6.04
Hydrophobic TM5 T 555 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 T 555 5x64 s15s16 F 245 C.s15s16.03
Polar C-term E 657 - s20c Y 404 C.s20c.14
Hydrophobic C-term E 657 - s20c Y 404 C.s20c.14
Van-der-waals C-term E 657 - s20c Y 404 C.s20c.14
Ionic TM3 E 466 3x49 s5s6 R 66 N.s5s6.02
Polar TM3 E 466 3x49 s5s6 R 66 N.s5s6.02