Beta-arrestin-2 - FZD10 complex model

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
FZD10 76.6
Beta-arrestin-2 79.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 16.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 440 6x29 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 440 6x29 s5s6 L 72 N.s5s6.08
Hydrophobic N-term F 71 - s11s12 L 192 C.s11s12.02
Van-der-waals N-term F 71 - s11s12 L 192 C.s11s12.02
Hydrophobic TM3 A 337 3x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 A 337 3x53 s5s6 V 71 N.s5s6.07
Hydrophobic N-term P 73 - s11s12 M 193 C.s11s12.03
Polar ICL2 K 341 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 K 341 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 K 341 - s15s16 F 245 C.s15s16.03
Hydrophobic N-term F 126 - s11s12 L 192 C.s11s12.02
Hydrophobic TM4 H 344 4x35 s5s6 L 69 N.s5s6.05
Van-der-waals TM4 H 344 4x35 s5s6 L 69 N.s5s6.05
Ionic ICL3 E 432 - S6 R 77 N.S6.02
Polar ICL3 E 432 - S6 R 77 N.S6.02
Hydrophobic ICL3 E 432 - S6 R 77 N.S6.02
Van-der-waals ICL3 E 432 - S6 R 77 N.S6.02
Hydrophobic TM6 L 440 6x29 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 L 440 6x29 s5s6 L 74 N.s5s6.10
Polar ICL3 E 432 - S6 K 78 N.S6.03
Hydrophobic ICL3 E 432 - S6 K 78 N.S6.03
Van-der-waals ICL3 E 432 - S6 K 78 N.S6.03
Polar C-term C 580 - S1 K 11 N.S1.03
Polar N-term N 125 - s11s12 D 195 C.s11s12.05
Hydrophobic N-term N 125 - s11s12 D 195 C.s11s12.05
Polar ICL2 K 341 - S5 Y 64 N.S5.12
Hydrophobic ICL2 K 341 - S5 Y 64 N.S5.12
Van-der-waals ICL2 K 341 - S5 Y 64 N.S5.12
Hydrophobic N-term M 121 - s11s12 L 192 C.s11s12.02
Polar N-term Q 13 - S11 E 186 C.S11.02
Hydrophobic TM5 V 426 5x75 s15s16 L 244 C.s15s16.02
Hydrophobic TM4 G 343 4x34 s5s6 L 69 N.s5s6.05
Polar TM5 V 426 5x75 S6 K 78 N.S6.03
Hydrophobic TM5 V 426 5x75 S6 K 78 N.S6.03
Polar C-term C 580 - s1s2 C 17 N.s1s2.04
Hydrophobic C-term C 580 - s1s2 C 17 N.s1s2.04
Van-der-waals C-term C 580 - s1s2 C 17 N.s1s2.04
Hydrophobic TM4 A 346 4x37 s8s9 T 137 N.s8s9.07
Hydrophobic TM2 P 259 2x40 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 P 259 2x40 s5s6 V 71 N.s5s6.07
Ionic N-term E 70 - S11 R 189 C.S11.05
Polar N-term E 70 - S11 R 189 C.S11.05
Van-der-waals N-term E 70 - S11 R 189 C.S11.05
Hydrophobic N-term E 70 - s11s12 F 191 C.s11s12.01
Van-der-waals N-term E 70 - s11s12 F 191 C.s11s12.01
Hydrophobic ICL3 G 430 - S6 K 78 N.S6.03
Polar N-term H 69 - s18s19 R 332 C.s18s19.02
Hydrophobic N-term H 69 - s18s19 R 332 C.s18s19.02
Van-der-waals N-term H 69 - s18s19 R 332 C.s18s19.02
Hydrophobic N-term I 66 - s18s19 G 334 C.s18s19.04
Van-der-waals N-term I 66 - s18s19 G 334 C.s18s19.04
Van-der-waals N-term Q 67 - S11 R 189 C.S11.05
Polar N-term E 70 - s11s12 L 192 C.s11s12.02
Hydrophobic N-term E 70 - s11s12 L 192 C.s11s12.02
Van-der-waals N-term E 70 - s11s12 L 192 C.s11s12.02
Hydrophobic ICL2 K 341 - s15s16 S 246 C.s15s16.04
Hydrophobic N-term E 70 - s18s19 G 333 C.s18s19.03
Van-der-waals N-term E 70 - s18s19 G 333 C.s18s19.03
Hydrophobic TM5 I 423 5x72 s15s16 F 245 C.s15s16.03
Polar ICL3 T 429 - S6 K 78 N.S6.03
Hydrophobic N-term F 126 - s11s12 S 194 C.s11s12.04
Van-der-waals N-term F 126 - s11s12 S 194 C.s11s12.04
Hydrophobic N-term F 126 - s11s12 M 193 C.s11s12.03
Van-der-waals N-term F 126 - s11s12 M 193 C.s11s12.03
Polar ICL2 W 342 - s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 W 342 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 W 342 - s8s9 T 137 N.s8s9.07
Van-der-waals TM5 M 427 5x76 S6 R 77 N.S6.02
Polar ICL3 E 432 - S6 D 79 N.S6.04
Hydrophobic ICL3 E 432 - S6 D 79 N.S6.04
Van-der-waals ICL3 E 432 - S6 D 79 N.S6.04
Hydrophobic N-term F 126 - s11s12 D 195 C.s11s12.05
Van-der-waals N-term F 126 - s11s12 D 195 C.s11s12.05
Hydrophobic ICL2 W 342 - s8s9 K 139 N.s8s9.09
Van-der-waals C-term V 581 - S1 K 11 N.S1.03
Hydrophobic N-term I 66 - s18s19 R 332 C.s18s19.02
Van-der-waals N-term I 66 - s18s19 R 332 C.s18s19.02
Hydrophobic TM3 W 334 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM4 G 343 4x34 s8s9 K 139 N.s8s9.09
Hydrophobic N-term P 129 - s11s12 L 192 C.s11s12.02
Polar TM4 G 343 4x34 s8s9 T 137 N.s8s9.07
Van-der-waals TM4 G 343 4x34 s8s9 T 137 N.s8s9.07
Polar N-term I 66 - s18s19 G 333 C.s18s19.03
Hydrophobic N-term I 66 - s18s19 G 333 C.s18s19.03
Van-der-waals N-term I 66 - s18s19 G 333 C.s18s19.03
Ionic TM4 E 345 4x36 s5s6 R 66 N.s5s6.02
Polar TM4 E 345 4x36 s5s6 R 66 N.s5s6.02
Hydrophobic TM4 E 345 4x36 s5s6 R 66 N.s5s6.02
Van-der-waals TM4 E 345 4x36 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 I 423 5x72 S6 F 76 N.S6.01
Van-der-waals TM5 I 423 5x72 S6 F 76 N.S6.01
Polar TM4 H 344 4x35 s5s6 D 70 N.s5s6.06
Hydrophobic ICL3 K 436 - s5s6 L 74 N.s5s6.10
Van-der-waals ICL3 K 436 - s5s6 L 74 N.s5s6.10
Hydrophobic N-term L 74 - s11s12 M 193 C.s11s12.03
Van-der-waals N-term L 74 - s11s12 M 193 C.s11s12.03
Ionic N-term E 63 - S18 K 327 C.S18.10
Polar N-term E 63 - S18 K 327 C.S18.10
Van-der-waals N-term E 63 - S18 K 327 C.S18.10
Hydrophobic ICL3 L 437 - s5s6 L 74 N.s5s6.10
Van-der-waals ICL3 L 437 - s5s6 L 74 N.s5s6.10
Hydrophobic TM5 V 426 5x75 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 V 426 5x75 s15s16 F 245 C.s15s16.03
Hydrophobic TM2 P 259 2x40 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 M 427 5x76 S6 F 76 N.S6.01
Hydrophobic TM5 M 427 5x76 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 M 427 5x76 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 I 444 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 I 444 6x33 s5s6 L 72 N.s5s6.08