ArrestinDb

Beta-arrestin-2 - FZD₁₀ complex model

Full

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
FZD₁₀	76.6
Beta-arrestin-2	79.4

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.6

iPTM Score: 0.7

PAE mean: 16.9

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Hydrophobic	TM6	L	440	6x29	s5s6	L	72	N.s5s6.08
Hydrophobic	N-term	F	71	-	s11s12	L	192	C.s11s12.02
Hydrophobic	TM3	A	337	3x53	s5s6	V	71	N.s5s6.07
Hydrophobic	N-term	P	73	-	s11s12	M	193	C.s11s12.03
Hydrophobic	ICL2	K	341	-	s15s16	F	245	C.s15s16.03
Hydrophobic	N-term	F	126	-	s11s12	L	192	C.s11s12.02
Hydrophobic	TM4	H	344	4x35	s5s6	L	69	N.s5s6.05
Hydrophobic	ICL3	E	432	-	S6	R	77	N.S6.02
Hydrophobic	TM6	L	440	6x29	s5s6	L	74	N.s5s6.10
Hydrophobic	ICL3	E	432	-	S6	K	78	N.S6.03
Hydrophobic	N-term	N	125	-	s11s12	D	195	C.s11s12.05
Hydrophobic	ICL2	K	341	-	S5	Y	64	N.S5.12
Hydrophobic	N-term	M	121	-	s11s12	L	192	C.s11s12.02
Hydrophobic	TM5	V	426	5x75	s15s16	L	244	C.s15s16.02
Hydrophobic	TM4	G	343	4x34	s5s6	L	69	N.s5s6.05
Hydrophobic	TM5	V	426	5x75	S6	K	78	N.S6.03
Hydrophobic	C-term	C	580	-	s1s2	C	17	N.s1s2.04
Hydrophobic	TM4	A	346	4x37	s8s9	T	137	N.s8s9.07
Hydrophobic	TM2	P	259	2x40	s5s6	V	71	N.s5s6.07
Hydrophobic	N-term	E	70	-	s11s12	F	191	C.s11s12.01
Hydrophobic	ICL3	G	430	-	S6	K	78	N.S6.03
Hydrophobic	N-term	H	69	-	s18s19	R	332	C.s18s19.02
Hydrophobic	N-term	I	66	-	s18s19	G	334	C.s18s19.04
Hydrophobic	N-term	E	70	-	s11s12	L	192	C.s11s12.02
Hydrophobic	ICL2	K	341	-	s15s16	S	246	C.s15s16.04
Hydrophobic	N-term	E	70	-	s18s19	G	333	C.s18s19.03
Hydrophobic	TM5	I	423	5x72	s15s16	F	245	C.s15s16.03
Hydrophobic	N-term	F	126	-	s11s12	S	194	C.s11s12.04
Hydrophobic	N-term	F	126	-	s11s12	M	193	C.s11s12.03
Hydrophobic	ICL2	W	342	-	s8s9	T	137	N.s8s9.07
Hydrophobic	ICL3	E	432	-	S6	D	79	N.S6.04
Hydrophobic	N-term	F	126	-	s11s12	D	195	C.s11s12.05
Hydrophobic	ICL2	W	342	-	s8s9	K	139	N.s8s9.09
Hydrophobic	N-term	I	66	-	s18s19	R	332	C.s18s19.02
Hydrophobic	TM3	W	334	3x50	s5s6	L	72	N.s5s6.08
Hydrophobic	TM4	G	343	4x34	s8s9	K	139	N.s8s9.09
Hydrophobic	N-term	P	129	-	s11s12	L	192	C.s11s12.02
Hydrophobic	N-term	I	66	-	s18s19	G	333	C.s18s19.03
Hydrophobic	TM4	E	345	4x36	s5s6	R	66	N.s5s6.02
Hydrophobic	TM5	I	423	5x72	S6	F	76	N.S6.01
Hydrophobic	ICL3	K	436	-	s5s6	L	74	N.s5s6.10
Hydrophobic	N-term	L	74	-	s11s12	M	193	C.s11s12.03
Hydrophobic	ICL3	L	437	-	s5s6	L	74	N.s5s6.10
Hydrophobic	TM5	V	426	5x75	s15s16	F	245	C.s15s16.03
Hydrophobic	TM2	P	259	2x40	s5s6	L	72	N.s5s6.08
Hydrophobic	TM5	M	427	5x76	S6	F	76	N.S6.01
Hydrophobic	TM5	M	427	5x76	s15s16	F	245	C.s15s16.03
Hydrophobic	TM6	I	444	6x33	s5s6	L	72	N.s5s6.08
Ionic	ICL3	E	432	-	S6	R	77	N.S6.02
Ionic	N-term	E	70	-	S11	R	189	C.S11.05
Ionic	TM4	E	345	4x36	s5s6	R	66	N.s5s6.02
Ionic	N-term	E	63	-	S18	K	327	C.S18.10
Polar	ICL2	K	341	-	s15s16	F	245	C.s15s16.03
Polar	ICL3	E	432	-	S6	R	77	N.S6.02
Polar	ICL3	E	432	-	S6	K	78	N.S6.03
Polar	C-term	C	580	-	S1	K	11	N.S1.03
Polar	N-term	N	125	-	s11s12	D	195	C.s11s12.05
Polar	ICL2	K	341	-	S5	Y	64	N.S5.12
Polar	N-term	Q	13	-	S11	E	186	C.S11.02
Polar	TM5	V	426	5x75	S6	K	78	N.S6.03
Polar	C-term	C	580	-	s1s2	C	17	N.s1s2.04
Polar	N-term	E	70	-	S11	R	189	C.S11.05
Polar	N-term	H	69	-	s18s19	R	332	C.s18s19.02
Polar	N-term	E	70	-	s11s12	L	192	C.s11s12.02
Polar	ICL3	T	429	-	S6	K	78	N.S6.03
Polar	ICL2	W	342	-	s8s9	T	137	N.s8s9.07
Polar	ICL3	E	432	-	S6	D	79	N.S6.04
Polar	TM4	G	343	4x34	s8s9	T	137	N.s8s9.07
Polar	N-term	I	66	-	s18s19	G	333	C.s18s19.03
Polar	TM4	E	345	4x36	s5s6	R	66	N.s5s6.02
Polar	TM4	H	344	4x35	s5s6	D	70	N.s5s6.06
Polar	N-term	E	63	-	S18	K	327	C.S18.10
Van-der-waals	TM6	L	440	6x29	s5s6	L	72	N.s5s6.08
Van-der-waals	N-term	F	71	-	s11s12	L	192	C.s11s12.02
Van-der-waals	TM3	A	337	3x53	s5s6	V	71	N.s5s6.07
Van-der-waals	ICL2	K	341	-	s15s16	F	245	C.s15s16.03
Van-der-waals	TM4	H	344	4x35	s5s6	L	69	N.s5s6.05
Van-der-waals	ICL3	E	432	-	S6	R	77	N.S6.02
Van-der-waals	TM6	L	440	6x29	s5s6	L	74	N.s5s6.10
Van-der-waals	ICL3	E	432	-	S6	K	78	N.S6.03
Van-der-waals	ICL2	K	341	-	S5	Y	64	N.S5.12
Van-der-waals	C-term	C	580	-	s1s2	C	17	N.s1s2.04
Van-der-waals	TM2	P	259	2x40	s5s6	V	71	N.s5s6.07
Van-der-waals	N-term	E	70	-	S11	R	189	C.S11.05
Van-der-waals	N-term	E	70	-	s11s12	F	191	C.s11s12.01
Van-der-waals	N-term	H	69	-	s18s19	R	332	C.s18s19.02
Van-der-waals	N-term	I	66	-	s18s19	G	334	C.s18s19.04
Van-der-waals	N-term	Q	67	-	S11	R	189	C.S11.05
Van-der-waals	N-term	E	70	-	s11s12	L	192	C.s11s12.02
Van-der-waals	N-term	E	70	-	s18s19	G	333	C.s18s19.03
Van-der-waals	N-term	F	126	-	s11s12	S	194	C.s11s12.04
Van-der-waals	N-term	F	126	-	s11s12	M	193	C.s11s12.03
Van-der-waals	ICL2	W	342	-	s8s9	T	137	N.s8s9.07
Van-der-waals	TM5	M	427	5x76	S6	R	77	N.S6.02
Van-der-waals	ICL3	E	432	-	S6	D	79	N.S6.04
Van-der-waals	N-term	F	126	-	s11s12	D	195	C.s11s12.05
Van-der-waals	C-term	V	581	-	S1	K	11	N.S1.03
Van-der-waals	N-term	I	66	-	s18s19	R	332	C.s18s19.02
Van-der-waals	TM4	G	343	4x34	s8s9	T	137	N.s8s9.07
Van-der-waals	N-term	I	66	-	s18s19	G	333	C.s18s19.03
Van-der-waals	TM4	E	345	4x36	s5s6	R	66	N.s5s6.02
Van-der-waals	TM5	I	423	5x72	S6	F	76	N.S6.01
Van-der-waals	ICL3	K	436	-	s5s6	L	74	N.s5s6.10
Van-der-waals	N-term	L	74	-	s11s12	M	193	C.s11s12.03
Van-der-waals	N-term	E	63	-	S18	K	327	C.S18.10
Van-der-waals	ICL3	L	437	-	s5s6	L	74	N.s5s6.10
Van-der-waals	TM5	V	426	5x75	s15s16	F	245	C.s15s16.03
Van-der-waals	TM5	M	427	5x76	s15s16	F	245	C.s15s16.03
Van-der-waals	TM6	I	444	6x33	s5s6	L	72	N.s5s6.08

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Main reference

Beta-arrestin-2 - FZD10 complex model Download Full