Arrestin-C - FZD10 complex model

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
FZD10 73.9
Arrestin-C 80.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 19.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM4 H 344 4x35 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 M 427 5x76 S6 F 71 N.S6.01
Van-der-waals TM5 M 427 5x76 S6 F 71 N.S6.01
Hydrophobic N-term P 73 - s18s19 T 336 C.s18s19.10
Hydrophobic ICL1 R 257 12x51 s5s6 I 67 N.s5s6.08
Hydrophobic TM4 A 346 4x37 s8s9 A 133 N.s8s9.07
Van-der-waals TM4 A 346 4x37 s8s9 A 133 N.s8s9.07
Ionic ICL3 K 436 - s5s6 E 65 N.s5s6.06
Polar ICL3 K 436 - s5s6 E 65 N.s5s6.06
Polar ICL3 G 431 - S6 R 72 N.S6.02
Hydrophobic N-term H 69 - s18s19 T 336 C.s18s19.10
Polar ICL2 K 341 - s15s16 Y 241 C.s15s16.03
Aromatic ICL2 K 341 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 K 341 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 K 341 - s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 M 427 5x76 S6 R 72 N.S6.02
Van-der-waals TM5 M 427 5x76 S6 R 72 N.S6.02
Polar N-term E 70 - s11s12 L 188 C.s11s12.02
Hydrophobic N-term E 70 - s11s12 L 188 C.s11s12.02
Van-der-waals N-term E 70 - s11s12 L 188 C.s11s12.02
Hydrophobic TM6 L 440 6x29 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 L 440 6x29 s5s6 I 67 N.s5s6.08
Hydrophobic N-term F 126 - s11s12 L 189 C.s11s12.03
Van-der-waals N-term F 126 - s11s12 L 189 C.s11s12.03
Polar TM3 A 338 3x54 s15s16 Y 241 C.s15s16.03
Polar N-term C 18 - s11s12 A 191 C.s11s12.05
Van-der-waals N-term C 18 - s11s12 A 191 C.s11s12.05
Hydrophobic ICL2 K 341 - s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 K 341 - s15s16 S 242 C.s15s16.04
Polar TM5 V 426 5x75 S6 K 73 N.S6.03
Van-der-waals TM5 V 426 5x75 S6 K 73 N.S6.03
Hydrophobic TM2 P 259 2x40 s5s6 I 67 N.s5s6.08
Hydrophobic ICL3 T 434 - S6 F 71 N.S6.01
Hydrophobic N-term F 71 - s11s12 L 188 C.s11s12.02
Van-der-waals N-term F 71 - s11s12 L 188 C.s11s12.02
Polar N-term C 18 - S11 R 186 C.S11.06
Hydrophobic N-term C 18 - S11 R 186 C.S11.06
Van-der-waals N-term C 18 - S11 R 186 C.S11.06
Polar ICL2 K 341 - S5 Y 59 N.S5.12
Hydrophobic ICL2 K 341 - S5 Y 59 N.S5.12
Van-der-waals ICL2 K 341 - S5 Y 59 N.S5.12
Hydrophobic N-term M 121 - s18s19 I 331 C.s18s19.05
Hydrophobic N-term I 66 - S11 R 185 C.S11.05
Van-der-waals N-term I 66 - S11 R 185 C.S11.05
Hydrophobic N-term F 124 - s18s19 I 331 C.s18s19.05
Van-der-waals N-term F 124 - s18s19 I 331 C.s18s19.05
Hydrophobic ICL3 L 437 - s5s6 L 69 N.s5s6.10
Van-der-waals ICL3 L 437 - s5s6 L 69 N.s5s6.10
Hydrophobic ICL3 K 436 - s5s6 G 68 N.s5s6.09
Hydrophobic N-term V 14 - s11s12 P 193 C.s11s12.07
Hydrophobic ICL3 L 437 - S6 F 71 N.S6.01
Van-der-waals ICL3 L 437 - S6 F 71 N.S6.01
Hydrophobic TM4 H 344 4x35 s5s6 L 64 N.s5s6.05
Van-der-waals TM4 H 344 4x35 s5s6 L 64 N.s5s6.05
Hydrophobic ICL1 R 257 12x51 s5s6 V 66 N.s5s6.07
Hydrophobic N-term Q 67 - s11s12 L 188 C.s11s12.02
Hydrophobic ICL3 L 437 - s5s6 I 67 N.s5s6.08
Van-der-waals ICL3 L 437 - s5s6 I 67 N.s5s6.08
Ionic N-term E 70 - S11 R 185 C.S11.05
Polar N-term E 70 - S11 R 185 C.S11.05
Polar N-term C 18 - s11s12 P 193 C.s11s12.07
Hydrophobic N-term C 18 - s11s12 P 193 C.s11s12.07
Van-der-waals N-term C 18 - s11s12 P 193 C.s11s12.07
Hydrophobic N-term F 126 - s18s19 L 332 C.s18s19.06
Hydrophobic TM5 I 423 5x72 S6 F 71 N.S6.01
Hydrophobic TM5 I 423 5x72 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 I 423 5x72 s15s16 Y 241 C.s15s16.03
Hydrophobic N-term P 73 - s18s19 L 332 C.s18s19.06
Van-der-waals N-term P 73 - s18s19 L 332 C.s18s19.06
Hydrophobic N-term E 70 - s18s19 T 336 C.s18s19.10
Hydrophobic TM5 M 427 5x76 S6 K 73 N.S6.03
Hydrophobic TM4 G 343 4x34 s8s9 K 135 N.s8s9.09
Van-der-waals TM4 G 343 4x34 s8s9 K 135 N.s8s9.09
Hydrophobic TM5 V 426 5x75 s15s16 L 240 C.s15s16.02
Hydrophobic N-term F 126 - s18s19 G 330 C.s18s19.04
Van-der-waals N-term F 126 - s18s19 G 330 C.s18s19.04
Hydrophobic TM6 M 441 6x30 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 Y 258 2x39 s5s6 I 67 N.s5s6.08
Van-der-waals TM2 Y 258 2x39 s5s6 I 67 N.s5s6.08
Polar TM4 G 343 4x34 s8s9 A 133 N.s8s9.07
Van-der-waals TM4 G 343 4x34 s8s9 A 133 N.s8s9.07
Hydrophobic N-term E 70 - s18s19 L 332 C.s18s19.06
Van-der-waals N-term E 70 - s18s19 L 332 C.s18s19.06
Hydrophobic N-term F 126 - s18s19 I 331 C.s18s19.05
Van-der-waals N-term F 126 - s18s19 I 331 C.s18s19.05
Hydrophobic TM5 M 427 5x76 s15s16 Y 241 C.s15s16.03
Ionic TM4 E 345 4x36 s5s6 R 61 N.s5s6.02
Polar TM4 E 345 4x36 s5s6 R 61 N.s5s6.02
Hydrophobic TM4 E 345 4x36 s5s6 R 61 N.s5s6.02
Van-der-waals TM4 E 345 4x36 s5s6 R 61 N.s5s6.02
Polar N-term S 17 - S11 R 186 C.S11.06
Hydrophobic N-term S 17 - S11 R 186 C.S11.06
Van-der-waals N-term S 17 - S11 R 186 C.S11.06
Hydrophobic ICL2 W 342 - s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 W 342 - s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 W 342 - s8s9 K 135 N.s8s9.09
Polar ICL3 L 437 - s5s6 G 68 N.s5s6.09
Hydrophobic ICL3 L 437 - s5s6 G 68 N.s5s6.09
Van-der-waals ICL3 L 437 - s5s6 G 68 N.s5s6.09